Clinical trials: Alveolitis
Hypersensitivity Pneumonitis
"Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity Pneumonitis"
Hypersensitivity Pneumonitis (HP) is an immune-mediated disease that manifests as interstitial lung disease after exposure to an inhaled antigen, often unidentified. HP can be classified as non-fibrotic or fibrotic HP.
- Trial name
- RUBY (NCT07210008)
- Testing
- Prednisolone
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Socket, Postoperative Infections
The Effect of Chlorhexidine + Hyaluronic Acid on Postoperative Wound Healing After Lower Third Molar Removal
Our aim is to evaluate chlorhexidine-hyaluronic acid containing gel on postoperative wound healing regarding impacted lower third molar surgery.
- Trial name
- NCT07044219
- Testing
- Third molar surgery
- Where
- Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Hypersensitivity Pneumonitis
Evaluation of the Efficacy of Pirfenidone in Progressive Chronic Hypersensitivity Pneumonitis
This study aims to evaluate the efficacy of pirfenidone in chronic hypersensitivity pneumonitis. This study included 40 adult patients (≥ 18 years) with a diagnosis of chronic progressive hypersensitivity pneumonitis.
- Trial name
- NCT04675619
- Testing
- Oral pirfenidone, Standard care
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Zagazig University
Hypersensitivity Pneumonitis
Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis
The central hypothesis is that a peer coach-delivered intervention that includes cognitive behavioral principles combined with theory-driven patient education will improve health-related quality of life (HRQOL) of patients with…
- Trial name
- RISE-HP (NCT06811389)
- Testing
- Re-imagining Interventions for Support and Education in Hypersensitivity Pneumonitis (RISE-HP), Staying Well
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Weill Medical College of Cornell University
Alveolitis of Jaw, Alveoli, Teeth; Inflammation
Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery
In the everyday clinical practice the incidence of minor complications is approximately 15-20% of the total number of third molar removals. Alveolitis (dry socket syndrome) may arise in 30-40% of the surgical tooth removals.
- Conditions
- Alveolitis of Jaw, Alveoli, Teeth; Inflammation, Dry Socket, Impacted Third Molar Tooth
- Trial name
- AITS (NCT03741894)
- Testing
- Iodoform, Wound closure using sutures, Chlorhexidine
- Where
- Hungary
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Hypersensitivity Pneumonitis
A Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis
Up to 150 patients with hypersensitivity pneumonitis will be enrolled at 7 clinical centers across the United States. Patients will be followed for 24 months to determine if biomarkers in the blood can predict disease progression.
- Trial name
- PREDICT-HP (NCT04844359)
- Where
- 7 sites in United States
- Volunteers
- 137 people
- Sponsor
- National Jewish Health
Alveolar Osteitis, Pain
Investigation of the Effect of I-PRF Application on Pain in Alveolitis
Literature review showed that there are no studies on the use of i-PRF in alveolitis cases. The aim of this study was to investigate the effect of i-PRF on the treatment of alveolitis.
- Conditions
- Alveolar Osteitis, Pain, Dry Socket
- Trial name
- NCT06761001
- Testing
- I-PRF, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Alveolitis, Systemic Sclerosis
A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis
The purpose of this study is to assess the safety and tolerability of imatinib (gleevec) in subjects who have systemic sclerosis.
- Trial name
- NCT00512902
- Testing
- Imatinib
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Pulmonary Hypertension, Hypersensitivity Pneumonitis
Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated…
- Trial name
- NCT05458635
- Testing
- Right heart catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hypersensitivity Pneumonitis
HypErsensitiVity PneumonITis: DiseAse Progression Characterization
EVITA is a multicentric Latin-American prospective cohort on chronic hypersensitivity pneumonitis. EVITA's objective is to identify phenotypes and/or endotypes associated with different disease trajectories measured primarily by…
- Trial name
- EVITA (NCT04961944)
- Testing
- Disease assessment
- Where
- 10 sites in Argentina, Brazil and 1 more
- Volunteers
- 150 people
- Sponsor
- Hospital do Coracao
Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis
129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease.
- Trial name
- NCT04677426
- Testing
- Hyperpolarized Xe129
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hypersensitivity Pneumonitis, Chronic Hypersensitivity Pneumonitis
Assessing Health Related Quality of Life in Hypersensitivity Pneumonitis
The objective of this study is to administer and validate a disease specific health related quality of life (HRQOL) survey for patients with Chronic Hypersensitivity Pneumonitis (CHP).
- Conditions
- Hypersensitivity Pneumonitis, Chronic Hypersensitivity Pneumonitis, Interstitial Lung Disease, Extrinsic Allergic Alveolitis
- Trial name
- CHP-HRQOL (NCT04273867)
- Testing
- Chronic Hypersensitivity Pneumonitis Health Related Quality of Life Survey Instrument
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Weill Medical College of Cornell University
Hypersensitivity Pneumonitis
Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a diffuse infiltrative pneumonitis (DIP) of immuno-allergic origin, caused by exposure to one or more antigenic substances of organic origin, in genetically predisposed individuals.
- Trial name
- PHSaDom (NCT05988437)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Chronic Respiratory Diseases, Cystic Fibrosis
Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases
Assessment of cardiovascular disorders using echocardiography and arterial stiffness; comparative noninvasive assessment of volatile organic compound (eVOC) exhale breath patterns in patients with different chronic respiratory…
- Conditions
- Chronic Respiratory Diseases, Cystic Fibrosis, Lymphangioleiomyomatosis, Hypersensitivity Pneumonitis
- Trial name
- NCT05727852
- Testing
- Breath test using the Compact PTR-TOF-MS, Portable cardiac monitor "CardioQvark", Assessment of arterial stiffness using the VaSera VS-1500N
- Where
- Russia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Interstitial Lung Disease, Idiopathic Interstitial Pneumonias
FAPI PET for Lung Fibrosis
This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in…
- Conditions
- Interstitial Lung Disease, Idiopathic Interstitial Pneumonias, Drug-Induced Pneumonitis, Hypersensitivity Pneumonitis
- Trial name
- FAPI ILD (NCT05365802)
- Testing
- 68Ga-FAPi-46, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Alveolar Osteitis
First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro
Alveolar Osteitis (AO) is a complication following extraction of a tooth. AO manifests by localized pain in and around the extraction site where the postoperative blood clot has been disintegrated.
- Trial name
- NCT04091399
- Testing
- Stamatological tamponade Contipro
- Where
- 11 sites in Czechia
- Volunteers
- 58 people
- Sponsor
- Contipro Pharma a.s.
Idiopathic Pulmonary Fibrosis
Azathioprine and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a diffuse lung disease, associated with the histological appearance of usual interstitial pneumonia (UIP), with an inexorably deteriorating clinical course.
- Trial name
- NCT00518310
- Testing
- AZAPRED
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Thorax National Institute
Avian Hypersensitivity Pneumonitis
Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung
This study aims at identifying bird proteins useful for diagnostic tests to determine the cause of Bird Fancier's Lung (BFL).
- Trial name
- HYPERSENS (NCT03056404)
- Testing
- additional blood sample, respiratory functional exploration
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
IPF, Fibrotic Lung Disease
Prognostic Score Comparison in IPF and HP
The goal of this retrospective observational study is to evaluate and compare the prognostic value of GAP, ILD-GAP, and CPI scoring systems in patients diagnosed with interstitial lung diseases (ILDs), specifically Idiopathic…
- Conditions
- IPF, Fibrotic Lung Disease, Hypersensitivity Pneumonitis, Interstitial Lung Disease (ILD)
- Trial name
- NCT07169253
- Testing
- GAP Index, ILD-GAP Index, Composite Physiologic Index (CPI)
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people
- Sponsor
- Saglik Bilimleri Universitesi
Hypersensitivity Pneumonitis, Exogenous Allergic Alveolitis
Stop Exogenous Allergic Alveolitis (EAA) in Childhood
Stop exogenous allergic alveolitis (EAA) or hypersensitivity pneumonitis in childhood: healthy into adulthood - a randomized, double-blind, placebo-controlled, parallel-group study to evaluate prednisolone treatment and course of…
- Trial name
- chILD-EU_EAA (NCT02631603)
- Testing
- Prednisolone
- Where
- 7 sites in Germany
- Volunteers
- 4 people
- Sponsor
- Matthias Griese