Clinical trials: Alzheimer's
Alzheimer Disease, Early Onset
PMN310 in Patients With Early Alzheimer's Disease (PRECISE-AD)
This Phase 1b study aims to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of multiple IV infusions of PMN310 in patients with early Alzheimer's disease.
- Trial name
- NCT06750432
- Testing
- PMN310
- Where
- 22 sites in United States
- Volunteers
- 144 people
- Sponsor
- ProMis Neurosciences, Inc
Alzheimer's Disease
Effect of Choline Alphoscerate on Cognitive Function in Alzheimer's Dementia
This study will evaluate the performance of Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) in patients with Alzheimer's disease (AD).
- Trial name
- ALFO-AD (NCT03441516)
- Testing
- Alfoatirin® Tab. + Aripezil® Tab., Aripezil® Tab.
- Where
- 6 sites in South Korea
- Volunteers
- 79 people
- Sponsor
- Yuhan Corporation
Alzheimer's Disease, Sleep Disorders
Effect of Activity on Sleep of Cognitively-Impaired Veterans
Sleep-activity rhythm disturbance is a prevalent, disabling symptom in cognitively-impaired (CI) elders. Their nocturnal sleep is light and inefficient with frequent awakenings.
- Trial name
- NCT00013182
- Testing
- social activity
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- US Department of Veterans Affairs
Stress, Psychological, Adaptation, Psychological
The Alzheimer's Companion Engagement (ACE) Project.
Black family caregivers of older adults with Alzheimer's disease and/or related dementias (ADRD), have an increased mortality risk related to pre-existing health conditions and stress.
- Trial name
- NCT04856462
- Testing
- Education Support
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alzheimer s Disease
Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease
This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD).
- Trial name
- NCT07324161
- Testing
- rTMS, Accelerated rTMS
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Fujian Medical University Union Hospital
Alzheimer Disease
Oral Fecal Microbiota Transplant Feasibility Study in Alzheimer's Disease
The goal of this study is to assess the safety and feasibility of an oral fecal microbiota transplant (FMT) intervention for Alzheimer's disease (AD).
- Trial name
- AMBITION (NCT03998423)
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Information About Alzheimer's Disease for Latinos in New York City
This study will assess the psychosocial and behavioral impacts of receiving Alzheimer's disease genetic risk assessment incorporating APOE genotypes among Latinos in northern Manhattan.
- Trial name
- IDEAL (NCT04471779)
- Testing
- Disclosure of APOE genotype
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Columbia University
Alzheimer Disease
Alzheimer's Disease Acitretin Medication
The trials investigates the changes of cerebral spinal fluid (CSF) soluble alpha-secretase cleaved APP (APPsα) levels under oral therapy with acitretin 30mg daily in patients with mild to moderate Alzheimer's disease (AD).The…
- Trial name
- ADAM (NCT01078168)
- Testing
- Acitretin
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- K. Lieb
Alzheimer's Disease
A Single and Multiple Ascending Dose Study to Evaluate the Safety and Pharmacokinetics of PU-AD in Healthy Subjects
This is a first in human Phase 1 study in two parts with healthy volunteers receiving a single dose of PU AD in three small cohorts and a multiple ascending dose in two small cohorts.
- Trial name
- NCT03935568
- Testing
- PU-AD
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samus Therapeutics, Inc.
Alzheimer's Disease
18F-AV-1451 Autopsy Study
This study is designed to test the relationship between ante-mortem flortaucipir Positron Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with Alzheimer's disease (AD), as measured at autopsy.
- Trial name
- NCT02516046
- Testing
- Flortaucipir F18, PET Scan
- Where
- 31 sites in United States, Australia
- Volunteers
- 156 people
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer's Disease
Exelon Patch and Combination With Memantine Comparative Trial
The primary objective is to compare the tolerability between rivastigmine patch monotherapy and combination therapy with memantine in patients with Alzheimer's disease (AD).
- Trial name
- EXPECT (NCT01025466)
- Testing
- Rivastigmine transdermal patch (Exelon patch), memantine, Rivastigmine transdermal patch
- Where
- 26 sites in South Korea
- Volunteers
- 206 people
- Sponsor
- Inha University Hospital
Alzheimer Disease
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB Alzheimer's Disease Center cohort.
- Trial name
- PiB ADC (NCT03503331)
- Testing
- [C-11]PiB-PET/MRI
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Behavioral Symptoms
Assessing the Effectiveness of an Approach for Vocal Behaviors in Older People Living in Nursing Homes
Between 13 and 60% of older people who live with Alzheimer's disease (ADRD) in long-term care facilities (LTCFs) manifest vocal behaviours (VB) that may seem inappropriate, e.g. moaning, screaming, calling out.
- Trial name
- NCT03506672
- Testing
- Approach based on the meanings of vocal behaviours, Usual practices
- Where
- 7 sites in Canada
- Volunteers
- 157 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Alzheimer's Disease and Related Dementias
Resilient Together for Dementia
The proposed study will establish the feasibility, acceptability and credibility of a novel live video dyadic resiliency intervention, Resilient Together for Dementia (RT-D), aimed at preventing chronic emotional distress and…
- Trial name
- RT-D ADRD (NCT06421545)
- Testing
- Resilient Together for Dementia
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alzheimer Disease, Parkinson Disease
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients
This double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine…
- Trial name
- NCT04044131
- Testing
- Metabolic Cofactor Supplementation, Sorbitol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Alzheimer Disease
Study to Evaluate the Effect of CT1812 Treatment on Amyloid Beta Oligomer Displacement Into CSF in Subjects With Mild to Moderate Alzheimer's Disease
This is a multi-center, Phase 1b, randomized, double-blind, placebo-controlled parallel-group trial in adults with mild to moderate AD.
- Trial name
- NCT03522129
- Testing
- CT1812
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Cognition Therapeutics
Traumatic Brain Injury, Post Traumatic Stress Disorder
A Study of Brain Aging in Vietnam War Veterans
Traumatic brain injury (TBI) and post traumatic stress disorder (PTSD) are common combat related problems and may be associated with a greater risk of Alzheimer's disease (AD).
- Conditions
- Traumatic Brain Injury, Post Traumatic Stress Disorder, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- DOD-ADNI (NCT01687153)
- Where
- 19 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Hypertension, Stress, Psychological
Stress and Hypertension in Dementia Caregivers
No demographic group is more at risk for the double jeopardy of caregiving stress and hypertension (HTN) than African American women caring for a family member with Alzheimer's disease and related dementias (ADRD).
- Trial name
- MIM-DASH (NCT05721482)
- Testing
- Caregiver Training
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Ohio State University
Alzheimer's Disease
Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI)
Re-read of brain amyloid scans acquired in previous AV-45 clinical studies by readers trained using updated reading methodology.
- Trial name
- NCT01565382
- Testing
- florbetapir F 18
- Volunteers
- 40 people
- Sponsor
- Avid Radiopharmaceuticals
Dementia, Alzheimer Type
Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type
The primary objective of the study is to compare the efficacy of aripiprazole with placebo in patients with psychosis associated with Alzheimer's dementia.
- Trial name
- NCT01438060
- Testing
- Aripiprazole (BMS-337039)
- Volunteers
- 232 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.