Clinical trials: Alzheimer Dementia
Alzheimer Disease
Therapeutic Role of Transcranial DCS in Alzheimer
The aim of this study is to evaluate the oxidative stress and brain damage biomarkers induced by tDCS in patients with AD and to assess the long term neurophysiological and behavioral effects after repeated daily tDCS sessions…
- Trial name
- NCT03313518
- Testing
- tDCS
- Volunteers
- 30 people
- Sponsor
- Assiut University
Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform
Hearing Aid and Individuals With Cognitive Disorders
This is a pilot study with the aim of evaluating the feasibility of the procedures of a future clinical trial that will help determine the impacts of hearing aid interventions on older patients with Alzheimer's Disease and…
- Conditions
- Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform, Mild Cognitive Impairment
- Trial name
- NCT04049643
- Testing
- Audiologist-based fitting, Service-only Fitting, Device-only fitting
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yu-Hsiang Wu
Alzheimer Disease, Subjective Cognitive Decline
Early Diagnosis of SCD Based on Radiogenomics
The incidence of AD dementia is increasing due to the aging population, putting a heavy burden on our society and economics. Exploring the mechanisms underlying SCD due to preclinical AD has scientific and clinical significance.
- Conditions
- Alzheimer Disease, Subjective Cognitive Decline, Neuroimaging, Gene
- Trial name
- NCT04696315
- Testing
- Multiple features extraction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Ying Han
Alzheimer Dementia (AD), Caregiver Burden of People With Dementia
VICA: A Virtual Care Assistant for Dementia Caregivers
This pilot randomized controlled trial evaluates the feasibility and preliminary efficacy of VICA, an AI-powered virtual care assistant that delivers evidence-based education, symptom monitoring, and coaching to informal…
- Trial name
- VICA (NCT07779785)
- Testing
- VICA - Virtual Informal Care Assistant, Education only BPSD mobile app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Alzheimer Disease, Healthy
A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy Participants
The main purpose of this study is to evaluate the safety and tolerability of LY3372993 in participants with AD, non-Japanese, and Japanese healthy participants who are of first-generation Japanese origin.
- Trial name
- NCT04451408
- Testing
- LY3372993
- Where
- 13 sites in United States, Japan
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Agitation, Psychosis
Escitalopram Treatment for BPSD in Alzheimer's Disease in Comparison to Risperidone
Behavioral and psychological symptoms of dementia (BPSD) are among the most distressing manifestations of dementia. Pharmacotherapy is frequently used and especially in institutional settings.
- Conditions
- Agitation, Psychosis, Alzheimer's Disease
- Trial name
- EscBPSD (NCT01119638)
- Testing
- Escitalopram, Risperidone
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Abarbanel Mental Health Center
Mild Cognitive Impairment
Molecular Cerebral Imaging in Incipient Dementia (MCI-ID) II
A substantial portion of people covered by Medicare will develop Alzheimer's disease and other forms of dementia that together devastate the lives of millions of people in the United States, and cost us a total of over $200…
- Trial name
- NCT02317250
- Testing
- Amyloid imaging, FDG-PET
- Sponsor
- University of California, Los Angeles
Alzheimer's Disease
Efficacy and Safety of Rivastigmine Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study was to investigate the 5cm^2 and 10cm^2 doses of rivastigmine transdermal patch in terms of efficacy and safety in patients with probable Alzheimer's Disease (MMSE [Mini Mental State Examination] 10-20).
- Trial name
- NCT00423085
- Testing
- Rivastigmine transdermal patch
- Where
- Japan
- Volunteers
- 859 people
- Sponsor
- Novartis Pharmaceuticals
Alzheimer's Disease
Greater-Bay-Area Healthy Aging Brain Study (GHABS)
The goal of this observational study is to learn about the pathophysiology characterization and evolutionary patterns of Alzheimer's disease (AD) in South China older adults. The primary purposes are as follows: 1.
- Trial name
- GHABS (NCT06183658)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Shenzhen Bay Laboratory
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
Alzheimer Disease
Next-Generation alzheImer'S Therapeutics
Is this the right time to use next-generation approaches in Alzheimer's disease (AD)? In recent years, several large clinical trials testing treatments for AD have failed, putting the entire field on a reset.
- Trial name
- ENERGISE (NCT06372587)
- Testing
- genetically encoded engineered proteins
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Caregiver Burden, Anxiety
Caring Relationships Expression Study
This study will examine a heart rate variability biofeedback (HRVB) intervention versus a music listening control (MLC) for 30 family caregivers (FCGs) of Alzheimer's disease (AD) (and related dementias: ADRD) patients to examine…
- Conditions
- Caregiver Burden, Anxiety, Stress
- Trial name
- CARES (NCT05627687)
- Testing
- Heart Rate Variability Biofeedback, Music Listening Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Alzheimer Disease, Dementia
Processing of Music in Alzheimer Patients
Correlation of musicality, brain atrophy in brain areas relevant for music processing and the stage of Alzheimer´s disease.
- Conditions
- Alzheimer Disease, Dementia, Amusia
- Trial name
- MUKU-DEM (NCT04132193)
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Dementia, Alzheimer Disease
EPIC: An Intervention for Early-stage AD Dyads - Adapted for Virtual Delivery
EPIC II (Early-Stage Partners in Care) is a research project designed to assist people with early-stage memory loss and their care partners by providing early-stage related education and skill-training sessions, held via Zoom…
- Conditions
- Dementia, Alzheimer Disease, Memory Loss
- Trial name
- NCT03144921
- Testing
- psychoeducational skills training intervention
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
- Trial name
- LIFUP-MCIAD (NCT05417555)
- Testing
- Low-Intensity Focused Ultrasound Pulsation (LIFUP)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS)
[18F]ACI-19626 PET in TDP-43 Proteinopathies
The goal of this clinical trial is to test whether we can reliably and safely measure the accumulation of pathological protein TDP-43 [involved in rare forms of dementia such as frontotemporal dementia (FTD) and in amyotrophic…
- Conditions
- Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), TDP-43 Proteinopathies, Suspected Limbic Predominant Age-related TDP-43 Encephalopathy (LATE)
- Trial name
- NCT06891716
- Testing
- [18F]ACI-19626
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AC Immune SA
Alzheimer Disease (AD)
Daridorexant for Alzheimer Disease Prevention
This study will evaluate whether daridorexant, a DORA sleep medication, can support brain health by promoting the clearance of proteins linked to the development and progression of Alzheimer's disease.
- Trial name
- PAD-DORA (NCT07213349)
- Testing
- Daridorexant 50 mg
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Healthy
A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.
A pilot study of the effects of Bacillus Calmette-Guérin (BCG) immunization on cerebrospinal fluid and blood-based biomarkers in older adults.
- Trial name
- NCT04507126
- Testing
- Bacillus Calmette-Guerin (BCG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease
The Safety and Efficacy of Long-term Treatment of PINS Stimulator System for Patients With Alzheimer's Disease
Purpose: The purpose of this clinical study is to verify the long term effectiveness and safety of a bilateral deep brain stimulation (DBS) produced by Beijing PINS Medical Co., Ltd.
- Trial name
- NCT02253043
- Testing
- Deep Brain Stimulation (Beijing PINS Medical Co., Ltd)
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Cognitive Dysfunction, Alzheimer Disease
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06733714
- Testing
- Transcranial Alternating Current Stimulation, Digital Cognitive Training
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.