Clinical trials: Alzheimer Dementia
Alzheimer Disease
Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences
Early in its development, Alzheimer's disease causes not only brain damage affecting different regions of the brain, such as the entorhinal cortex, the anterior cingulate cortex, and the prefrontal lobe, but also a cognitive…
- Trial name
- MAPdP (NCT03991624)
- Testing
- cognitive assessment, Inhibition evaluation, Assessment of mental flexibility
- Where
- 4 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Alzheimer Disease, Presbycusis
Age-related Hearing Loss and Lexical Disorders
In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients.
- Conditions
- Alzheimer Disease, Presbycusis, Lexical Syntactic Disorder
- Trial name
- LOOP (NCT03638323)
- Testing
- Speech therapy
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Alzheimer's Disease
Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease
A multi-center, double-blind, placebo-controlled out-patient, safety, tolerability, and pilot efficacy study of intramuscular AN-1792 in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00021723
- Testing
- AN-1792 also known as AIP-001
- Where
- 11 sites in United States
- Volunteers
- 375 people
- Sponsor
- JANSSEN Alzheimer Immunotherapy Research & Development, LLC
Alzheimer Disease
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD.
- Trial name
- NCT04740580
- Testing
- Glycine, N-acetylcysteine, Alanine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Healthy Volunteers, Alzheimer Disease
Phase 1 Test-retest Evaluation of [18F]MNI-958 PET
The overall goal of this protocol is to evaluate [18F]MNI-958 also known as APN-0000455 or PM-PBB3, a tau targeted radiopharmaceutical.
- Conditions
- Healthy Volunteers, Alzheimer Disease, Progressive Supranuclear Palsy
- Trial name
- NCT03545789
- Testing
- [18F]MNI-958
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Invicro
Alzheimer Disease
SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)
To investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in early AD dementia (early AD) subjects.
- Trial name
- SIGNAL-AD (NCT04381468)
- Testing
- Pepinemab
- Where
- 14 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vaccinex Inc.
Alzheimer's Disease
Control and Intervention Programme on Alzheimer's Disease Risk Factors
Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD).
- Trial name
- ALFAlife (NCT02772523)
- Testing
- Lifestyle recommendations
- Where
- Spain
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer Disease
Isotopic Imaging for Prodromal Alzheimer's Disease
The primary objective of this study is to characterize cerebral metabolism modifications using 18F-FDG PET technology and perfusion with 99MTC-ECD SPECT in patients with prodromal Alzheimer's Disease drawn from a high risk…
- Trial name
- ISALP (NCT01231295)
- Where
- 25 sites in France
- Volunteers
- 143 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mild Cognitive Impairment, Cognitive Impairment
SNIFF - Combo INI+EMPA Trial
The proposed pilot study will provide safety and efficacy preliminary data regarding singular and combined effects of two therapeutic approaches, intranasal insulin and treatment with the sodium-glucose cotransporter type 2…
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05081219
- Testing
- Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alzheimer's Disease, Cortical Basal Syndrome
18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls
This is an open-label study to evaluate the performance of a novel tau imaging ligand in up to 36 subjects (12 AD, 3 FTD, 3 PSP, 3 CBS, 3 VCI and 12 HV).
- Conditions
- Alzheimer's Disease, Cortical Basal Syndrome, Frontotemporal Dementia, Progressive Supranuclear Palsy
- Trial name
- NCT03625128
- Testing
- F-18
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Dementia
Efficacy of 1072nm Infrared Stimulation on Executive Functioning in Dementia
This study will employ a double-blind, placebo-controlled approach to assess the effect of 1072nm infrared (IR) phototherapy on the behavioral and cognitive symptoms associated with early and mid-stage dementia.
- Trial name
- NCT01059877
- Testing
- 1072nm infrared Photobiomodulation, Photobiomodulation SIMULATED
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Quietmind Foundation
Alzheimer Disease, Dementia
Supporting Caregivers of Persons With Dementia: A Pilot Study
The purpose of this study is to pilot the home Environmental Skill-Building Program (ESP) and an educational control intervention with persons with dementia and their caregivers (n=40) in preparation for a larger double-blind…
- Trial name
- NCT00908492
- Testing
- Education Control, Environmental Skill Building
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiac Arrhythmia, Ventricular Fibrillation
Emotional Regulation in Patients With Implanted Automatic Defibrillator
The general objective of the study was to evaluate the impact of two emotional regulation programs, one standardized and face-to-face (MBSR: Mindfulness Based Stress Reduction) and, another, implemented through a mobile phone…
- Conditions
- Cardiac Arrhythmia, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- NCT04235881
- Testing
- Mindfulness-based stress reduction program, App REM volver a casa
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Alzheimer Disease, Dementia, Mixed
Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Conditions
- Alzheimer Disease, Dementia, Mixed, Dementia, Behavior Problem
- Trial name
- tTED (NCT03846492)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Alzheimer Disease
Cognitive and Neurophysiological Effects of Raloxifene in Alzheimer's Disease
The aim of this study is to determine the effectiveness of treatment with raloxifene, an estrogen-like medication approved by the Food and Drug Administration for the treatment of osteoporosis, in improving memory and the ability…
- Trial name
- NCT00065767
- Testing
- Raloxifene
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease, Dementia
Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
The primary aim is to determine whether Divalproex ER or one of the atypical antipsychotics is more effective improving dementia related behavioral symptoms in patients with dementia, and evaluate the impact of such improvements…
- Conditions
- Alzheimer's Disease, Dementia, Behavioral Symptoms
- Trial name
- NCT00375557
- Testing
- Divalproex ER, Quetiapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Mild Cognitive Impairment, Alzheimer's Disease
Home-Based Assessment for Alzheimer Disease Prevention
The purpose of this study is to evaluate three methods of performing home-based assessments in Alzheimer's Disease (AD) prevention trials. The initial in-person assessment will be done in the clinic or at home.
- Trial name
- HBA (NCT00546767)
- Testing
- Mail and Live Phone, Interactive Voice Response (IVR), Home-based Computer Kiosk
- Where
- 28 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alzheimer Disease, Parkinson Disease
Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device
Primary Objective: The primary objective of this pilot study is to gain voluntary feedback from patients with neurological diseases and their caregivers regarding their experiences using the MemorEM head device.
- Conditions
- Alzheimer Disease, Parkinson Disease, Frontotemporal Dementia, Cortico Basal Degeneration
- Trial name
- MemorEM (NCT07222605)
- Testing
- MemorEM
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- eQ8Health Corporation d/b/a CareONE Concierge
Alzheimer´s Disease
AD01 Follow up Extension Visit
Patients who were vaccinated with AFFITOPE AD01 during AFFiRiS001 will undergo a long-term follow-up period to get more information regarding the safety profile of AFFITOPE AD01.
- Trial name
- NCT01225809
- Where
- Austria
- Volunteers
- 17 people
- Sponsor
- Affiris AG