Clinical trials: Alzheimers Disease Prevention
Stress, Psychological, Stress, Systemic
Systemic Stress Prevention Via Application SysLife© for Companies
The purpose of this study is to investigate the efficacy of systemic stress prevention via SysLife© application in a prospective, interventive, balanced, monocentric, explanatory pilot randomized controlled trial (RCT), with…
- Conditions
- Stress, Psychological, Stress, Systemic, Application
- Trial name
- NCT05828693
- Testing
- SysLife©, SysLife©, as intervention after closing the RCT-design
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Witten/Herdecke
Postpartum Depression, Postpartum Anxiety
Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention
Postpartum depression (PPD) affects up 10-15% of mothers overall, but the rate of PPD can be as high as 25% among mothers with personal or obstetric risk factors.
- Conditions
- Postpartum Depression, Postpartum Anxiety, Stress
- Trial name
- NCT06365645
- Testing
- M.Bapp, App-based parenting education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Alzheimer's Disease, Dementia
DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease
This is an open label study to treat dominantly inherited Alzheimer's disease (DIAD) mutation carrier participants from the DIAN-TU-001 gantenerumab Open Label Extension (OLE) period with lecanemab to determine the effects of…
- Conditions
- Alzheimer's Disease, Dementia, Alzheimer's Disease, Familial
- Trial name
- DIAN-TU (NCT06384573)
- Testing
- lecanemab
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Alzheimer Disease
Multiregional rtfMRI Neurofeedback for the Prevention of Alzheimer's Disease (NPAD)
This study aims to predict cognitive decline using a performance endophenotype of neuro-feedback based on functional magnetic resonance imaging in real time in a population at risk for Alzheimer's disease (AD).
- Trial name
- NPAD (NCT03173846)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Low Back Pain
Internet App to Self-Manage Occasional Low Back Pain
Nonspecific low back pain (NLBP) is the diagnosis for 85% of low back pain sufferers with no underlying medical cause (e.g., herniated disc, spinal stenosis) that requires physician care.
- Trial name
- BackPain2 (NCT01950091)
- Testing
- FitBack on-line intervention, Alternative Website Control
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function, daily function, psychosocial status, and neural plasticity in seniors with genetic…
- Trial name
- NCT05163067
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged…
- Trial name
- WellderlyBrain (NCT07646054)
- Testing
- Education
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Scripps Translational Science Institute
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Depression
Prevention of Depression in Spouses of People With Cognitive Impairment
This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia.
- Trial name
- NCT00321971
- Testing
- PST-MCI/AD Caregiving, NT-MCI/AD Caregiving
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Wisconsin Alzheimer's Disease Research Center, Wisconsin Registry for Alzheimer's Prevention
Speech Pattern Evaluation and Analysis for Knowledge of AD
The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD).
- Trial name
- SPEAK-AD (NCT06230783)
- Testing
- TalkTracker
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Prevention
Management of Dementia With Olive Oil Leaves - GOLDEN
Mild Dementia (Mild Dementia) is a state of mind disorder (memory, reason, attention, concentration, time orientation) with difficulty in the complex activities of everyday life (bank accounts, shopping, transportation, etc).The…
- Trial name
- GOLDEN (NCT04440020)
- Testing
- Beverage of Olive Oil Leaves, Mediterranean Diet
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Dementia, Alzheimer's Disease
"Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program"
A Pilot Study for the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia program (HALT-AD). This initial four-months pilot study will focus on at least three educational courses (introduction to…
- Conditions
- Dementia, Alzheimer's Disease, Dementia Prevention
- Trial name
- HALT-AD (NCT05350410)
- Testing
- HALT-AD
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alzheimer's Disease
Control and Intervention Programme on Alzheimer's Disease Risk Factors
Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD).
- Trial name
- ALFAlife (NCT02772523)
- Testing
- Lifestyle recommendations
- Where
- Spain
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Mild Cognitive Impairment, Alzheimer's Disease
Home-Based Assessment for Alzheimer Disease Prevention
The purpose of this study is to evaluate three methods of performing home-based assessments in Alzheimer's Disease (AD) prevention trials. The initial in-person assessment will be done in the clinic or at home.
- Trial name
- HBA (NCT00546767)
- Testing
- Mail and Live Phone, Interactive Voice Response (IVR), Home-based Computer Kiosk
- Where
- 28 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alzheimer Disease, Dementia
Financial Incentives and Recruitment to the APT Webstudy
This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy.
- Conditions
- Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
- Trial name
- FIND-AD (NCT06033066)
- Testing
- Financial Incentives, Message
- Where
- United States
- Volunteers
- 44,844 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer's Disease
Effects of Simvastatin on Biomarkers
A year-long randomized, double-blind, placebo-controlled trial of simvastatin to see if it produces beneficial changes in cerebral spinal fluid proteins associated with Alzheimer's disease.
- Trial name
- SimBio (NCT01142336)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Washington
Prodromal Alzheimer's Disease, Alzheimer Disease
COGNIFOOD-Changing the Carbohydrate/Fat-ratio to Prevent Cognitive Decline and Alzheimer Pathology: A Pilot Study
A 2-arm (sequence), 2-period, 2-treatments, single blinded (outcome assessor), randomized crossover-trial (12+12 weeks with immediate contrast) comparing a low-carbohydrate-high-fat diet (LCHF) with a high-carbohydrate-low-fat…
- Conditions
- Prodromal Alzheimer's Disease, Alzheimer Disease, Mild Cognitive Impairment, Neurocognitive Disorders
- Trial name
- NCT06105320
- Testing
- LCHF, HCLF
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Alzheimer's Disease
Alzheimer's Prevention Through Exercise
The purpose of this study is to learn about the possible benefits of aerobic exercise in controlling or reducing the amount of amyloid present in the brain, reducing changes in brain structure that may lead to Alzheimer's Disease…
- Trial name
- APEx (NCT02000583)
- Testing
- Aerobic Exercise, Standard of Care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Kansas Medical Center