Clinical trials: Ambulation Disorder, Neurologic
Ambulation Difficulty, Gait, Unsteady
The Sensorimotor Locus of Balance Control in Elderly Gait
The aging population is at an exceptionally high risk of debilitating falls, contributing significantly to reduced independence and quality of life.
- Conditions
- Ambulation Difficulty, Gait, Unsteady, Fall, Position Sense Disorders
- Trial name
- NCT03341728
- Testing
- Optical flow perturbations, Normal walking
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Stroke
Understanding Different Parameters in Locomotor Training (a Type of Walking Training) for Person After a Stroke
This is a research study to understand how people who have experienced a stroke walk in order to develop better and more effective types of therapy.
- Trial name
- NCT00712179
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Study of Fampridine-SR Tablets in Multiple Sclerosis Patients
The purpose of the study is to show that individuals treated with Fampridine-SR tablets are significantly more likely to have consistent improvements in their walking than those treated with placebo tablets.
- Trial name
- NCT00483652
- Testing
- Fampridine-SR
- Where
- 40 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Acorda Therapeutics
Cerebral Palsy, Central Nervous System Diseases
Power Training Combined With Interval Treadmill Training
Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life.
- Conditions
- Cerebral Palsy, Central Nervous System Diseases, Brain Damage, Chronic
- Trial name
- PT³ (NCT03625570)
- Testing
- Power training combined with interval treadmill training, Strength training combined with traditional treadmill training
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Paraplegia
The ReWalk Exoskeletal Walking System for Persons With Paraplegia
It is well appreciated that an extreme sedentary lifestyle from paralysis, contributes to many secondary medical problems such as diabetes and insulin resistance, obesity, constipation, poor blood pressure regulation…
- Trial name
- VA_ReWalk (NCT01454570)
- Testing
- powered exoskeleton
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Multiple Sclerosis
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR Tablets in Multiple Sclerosis Patients Who Participated in the MS-F203 Trial
The purpose of this study is to evaluate the safety, tolerability and activity of Fampridine-SR when administered for up to 36 additional months, or until it becomes commercially available whichever comes first, in subjects who…
- Trial name
- NCT00648908
- Testing
- Fampridine-SR
- Where
- 32 sites in United States, Canada
- Volunteers
- 269 people
- Sponsor
- Acorda Therapeutics
Osteoarthritis, Knee
Effect of Knee Pain on Walking Biomechanics
The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking.
- Trial name
- NCT05670236
- Testing
- Lidocaine Hydrochloride
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cardiac Failure, Heart Failure
Insomnia Self-Management in Heart Failure
Chronic insomnia may contribute to the development and exacerbation of heart failure (HF), incident mortality and contributes to common and disabling symptoms (fatigue, dyspnea, anxiety, depression, excessive daytime sleepiness…
- Conditions
- Cardiac Failure, Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- HSS (NCT02660385)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Self-Management Education for Heart Failure
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Yale University
Stroke
Development of Walk Assist Device to Improve Community Ambulation
Hypothesis/Specific Aims: The purpose of this study is to determine the effect of training with the Stride Management Assist (SMA) device vs.
- Trial name
- NCT01994395
- Testing
- The Stride Management Assist (SMA) System, Impairment based therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Enhancing Corticospinal Activation for Improved Walking Function
For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation…
- Trial name
- NCT03237234
- Testing
- Motor Skill Training, Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shepherd Center, Atlanta GA
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Multiple Sclerosis
Locomotor Training in Persons With Multiple Sclerosis
Locomotor training is a new exercise modality that emphasizes task specificity to promote learning and neural plasticity. It has been reported to improve walking in patients with stroke, spinal cord injury and cerebral palsy.
- Trial name
- NCT00607126
- Testing
- Lokomat, resistive training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis
Can Transcranial Direct Current Stimulation Improve Ambulation and Fatigue Resistance in People With MS?
In this project the investigators will be using non-invasive brain stimulation on people with multiple sclerosis (PwMS) to improve leg muscle function. Two groups of participants will be recruited.
- Trial name
- NCT02987621
- Testing
- tDCS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Colorado State University
Arthralgia, Trouble Balancing
Even-Up to Minimize Secondary Site Pain For Ankle Fracture
Evaluating impact of use of Even-Up shoe wear device for patients treated in CAM boot walker for an ankle fracture. Randomized controlled trial, randomizing patients into control group with boot treatment only versus boot…
- Trial name
- NCT04164563
- Testing
- Even-Up
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Transcutaneous Spinal Stimulation, Walking
Spinal Cord Stimulation to Augment Activity Based Therapy
Involuntary muscle activity, often called spasticity, is a common problem following spinal cord injury (SCI) that can make it hard to move.
- Conditions
- Transcutaneous Spinal Stimulation, Walking, Spasticity, Human
- Trial name
- NCT03240601
- Testing
- Transcutaneous spinal stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shepherd Center, Atlanta GA
Parkinson Disease
Exercise and Parkinson's: Comparing Interventions and Exploring Neural Mechanisms
Parkinson disease (PD) is characterized by substantial disability and reduced quality of life, both of which can be attributed in large part to difficulties with walking.
- Trial name
- NCT01768832
- Testing
- Treadmill, Tango, Stretching
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Washington University School of Medicine
Stroke
Biofeedback to Increase Propulsion During Walking After Stroke
Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months…
- Trial name
- NCT02667392
- Testing
- Gait Training with Biofeedback, Gait Training with Verbal Feedback
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Lower Limb Injury, Stroke
Assistive Hip Exoskeleton Study for Stroke
The increased metabolic and biomechanical demands of ambulation limit community mobility in persons with lower limb disability due to neurological damage.
- Trial name
- NCT03924765
- Testing
- Powered hip exoskeleton
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgia Institute of Technology
Multiple Sclerosis
Wearable Lower Extremity Exoskeleton to Promote Walking in Persons With Multiple Sclerosis
The purpose of this study is to investigate whether a wearable robotic exoskeleton can help people with multiple sclerosis (MS) to walk again.
- Trial name
- NCT02519244
- Testing
- Ekso® (Wearable lower limb exoskeleton)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stroke
Locomotor Experience Applied Post Stroke Trial
The purpose of this study is to compare two different treatments to improve walking after stroke (or post-stroke).
- Trial name
- LEAPS (NCT00243919)
- Testing
- Early locomotor training program, Late locomotor training program, Home Exercise Program
- Where
- 8 sites in United States
- Volunteers
- 408 people
- Sponsor
- Duke University