Clinical trials: Amino Acids
Phenylketonuria (PKU)
PKU Microtablets Case Studies
Phenylalanine (Phe) free protein substitutes are typically presented in ready to drink liquid or powder format and are made up with water to a set volume.
- Trial name
- NCT07671859
- Testing
- PKU Microtablet protein substitute
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nutricia UK Ltd
Healthy Females, Protein Requirement
Determination of Protein Requirements in Elderly Female Subjects >75 Yrs Old
Minimal data are available on protein requirements throughout the lifespan. Currently available recommendations are based on nitrogen balance data. The limitations of the nitrogen balance method have been well described.
- Trial name
- NCT01604980
- Testing
- Protein intake.
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy Women of Child Bearing Potential
Metabolic Availability of Methionine in Mung Beans
The goal of this study is to determine the protein quality of Philippine mung beans. The main objective of this study is to determine the metabolic availability of methionine in mung beans that the body can use.
- Trial name
- NCT06184984
- Testing
- Metabolic availability of methionine in mung beans
- Where
- Philippines
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Food and Nutrition Research Institute, Philippines
Cytomegalovirus Retinitis, HIV Infections
A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis
To determine the safety and tolerance of 3 dosage levels of human anti-cytomegalovirus (CMV) monoclonal antibody (SDZ MSL-109) when administered once every 2 weeks for a total of 8 doses during the maintenance phase of…
- Trial name
- NCT00002016
- Testing
- Sevirumab
- Where
- 2 sites in United States
- Sponsor
- Sandoz
Non-melanomatous Skin Cancer
Photodynamic Therapy in Treating Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photodynamic therapy using aminolevulinic acid cream may be effective in treating patients with skin cancer.
- Trial name
- NCT00002963
- Testing
- aminolevulinic acid hydrochloride, conventional surgery
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Frail Elderly Syndrome, Physical Exercise
Effects of a Multicomponent Exercise and Supplementation of BCAA´s in Immunity System Dwelling Elderly
The frailty syndrome (FS) is characterized by a multifactorial clinical syndrome, which includes 5 items, 1 - Change in body composition, 2 - Holding force, 3 - Fatigue reported, 4 - Reduction of walking speed, 5 - Low physical…
- Trial name
- NCT04376463
- Testing
- Branched Chain Aminoacid
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Healthy
Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise
The overall goal of this investigation was to determine the impact of branch-chained amino acids (BCAAs) supplementation on serotonin and associated metabolites during endurance exercise on healthy individuals.
- Trial name
- NCT04969536
- Testing
- Branched Chain Amino Acids
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Montana State University
Acute Kidney Injury
Amino Acids for Cardiac Surgery Associated AKI
The purpose of this study is to assess the feasibility of amino acid infusions in pediatric cardiac surgery patients.
- Trial name
- AKI (NCT07001098)
- Testing
- Amino Acids
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Hot Flashes
Amino Acid Therapy for Hot Flashes in Postmenopausal Women
The purpose of this study is to determine the safety, tolerability, and effectiveness of the amino acid L-isoleucine in the treatment of hot flashes in postmenopausal women.
- Trial name
- NCT00081952
- Testing
- L-norleucine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pregnancy
Determination of Protein Requirements in Pregnancy
Protein is an essential part of our diet. It is used to build muscle and body tissue, send signals throughout our body and to support the immune system.
- Trial name
- NCT01784198
- Testing
- Protein Intake
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Nutrient Intake
Leucine Requirements in School-Age Children
Leucine is an essential amino acid, which serves a special purpose of signaling cell growth in muscle in addition to making up protein.
- Trial name
- NCT07492095
- Testing
- Leucine Intake
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Argininosuccinic Aciduria, Carbamoyl-Phosphate Synthase I Deficiency
The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity
Objectives: To study nutrition and immune system problems in people with urea cycle disorders. To study how people with urea cycle disorders and healthy volunteers respond to standard flu and/or hepatitis A vaccines.
- Conditions
- Argininosuccinic Aciduria, Carbamoyl-Phosphate Synthase I Deficiency, Citrullinemia, Ornithine Carbamoyltransferase Deficiency
- Trial name
- NCT01421888
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Urea Cycle Disorders, Inborn, Other Metabolic Diseases
Protein Sorbent Properties of Montmorillonite in Vitro and in Vivo Models
Montmorillonite (MONT) is a phyllosilicate layered mineral with unique physicochemical properties, such as swelling and cation exchange capability.
- Trial name
- NCT02124330
- Testing
- montmorillonite 5 g, montmorillonite 3 g, Montmorillonite 1 g
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Luca Ronfani
Healthy
Sulphur Amino Acid Requirements in Adults >60 Years
This study aims to determine the requirements for the sulphur amino acids in adults over the age of 60 years: 1. the total sulphur amino acid requirement as methionine only. Methionine is an essential amino acid. 2.
- Trial name
- NCT04595188
- Testing
- Sulphur amino acids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Liver Diseases, Hepatic Encephalopathy
Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects
The purpose of this study is to determine whether Branched chain Amino Acids enhances the uptake of ammonia in muscle tissue.
- Conditions
- Liver Diseases, Hepatic Encephalopathy, Hepatic Insufficiency
- Trial name
- NCT00931060
- Testing
- Branched chain amino acids
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Critical Illness, Protein Metabolism
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Introduction: Protein loss during critical illness is an important problem and is shown to predict overall survival. In animal studies, infusion of leucine is shown to increase the synthesis of muscle protein by 30-40% and…
- Conditions
- Critical Illness, Protein Metabolism, Pharmaconutrients
- Trial name
- NCT01461603
- Testing
- Vamin (Fresenius Kabi), 3hydroxybutyrate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Propionic Acidemia, Type I and/or Type II, Methylmalonic Acidemia
Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia
The overall objective of this drug trial is to determine whether the treatment of acute hyperammonemia with N-carbamyl-L-glutamate (NCG, Carglumic acid) in propionic acidemia (PA), methylmalonic acidemia (MMA), late-onset CPS1…
- Conditions
- Propionic Acidemia, Type I and/or Type II, Methylmalonic Acidemia, Carbamoyl-Phosphate Synthase I Deficiency Disease, Ornithine Carbamoyltransferase Deficiency
- Trial name
- STO (NCT01599286)
- Testing
- Carbaglu
- Where
- 9 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mendel Tuchman
Muscle Metabolism
The Muscle Protein Synthetic Response of Algal and Fungal Protein
Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges.
- Trial name
- SCAM (NCT05016557)
- Testing
- Protein ingestion
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
This study has two protocols the aims of which are: 1. To identify age-related effects of AA on incretin secretion and whether and to what extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in…
- Trial name
- Incretin (NCT02370745)
- Testing
- GLP-1, Insulin Actrapid, Oral amino acids
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Frail Elderly
Resistance Exercise Training and Amino Acid Leucine Supplementation in Frail Elderly Women
Frailty is a clinical entity associated with an increase in risk for disease and death and becomes more common as people age. Frailty has a strong relationship with the age-related loss of muscle and strength, termed sarcopenia.
- Trial name
- NCT01922167
- Testing
- Leucine, Alanine
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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