Clinical trials: Amino Acids
Aging, Undernutrition
Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products
This study aims to assess the digestibility and efficacy of the study groups previously developed innovative plant-based protein and fibre products.
- Conditions
- Aging, Undernutrition, Appetite Loss, Age-Related Sarcopenia
- Trial name
- NCT05420142
- Testing
- Net peripheral AA appearance following ingestion of 3 selected PPF products compared to whey
- Where
- 2 sites in Ireland, Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Benign Paroxysmal Positional Vertigo (BPPV), Vestibular Migraine
Metabolic Disorders and Vertigo
The purpose of investigation is to assess the levels of metabolic factors (hydroxyvitamin D, homocysteine) between patients with vestibular dysfunction of peripheral origin (BPPV) and central origin (vestibular migraine).
- Conditions
- Benign Paroxysmal Positional Vertigo (BPPV), Vestibular Migraine, Central Positional Vertigo, Vestibular Neuritis
- Trial name
- NCT04935970
- Testing
- diagnostic blood test, neuropsychological test
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hyperhomocysteinemia
Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.
The clinical trial assesses the effectiveness and safety of a genetically-determined personalized approach to prescribing bioactive substances in patients with elevated blood homocysteine levels.
- Trial name
- PERBIO-HC (NCT06264570)
- Testing
- B-TMG supplementation, B-SAM supplementation
- Where
- Russia
- Volunteers
- 111 people
- Sponsor
- S.LAB (SOLOWAYS)
Phenylketonuria
A Study of PTC923 in Participants With Phenylketonuria
The main purpose of this trial is to evaluate the efficacy of PTC923 in reducing blood phenylalanine (Phe) levels in participants with phenylketonuria as measured by mean change in blood Phe levels from baseline to Weeks 5 and 6…
- Trial name
- NCT05099640
- Testing
- PTC923
- Where
- 43 sites in United States, Australia and 13 more
- Volunteers
- 157 people
- Sponsor
- PTC Therapeutics
Amino Acid Absorption
Changes in Amino Acid Absorption After Adding a Probiotic to an Acute Protein Feeding
The purpose of this study is to examine the pharmacokinetic pattern of amino acid absorption after a two-week pattern of milk protein supplementation with and without the addition of Bacillus coagulans GBI-30, 6086.
- Trial name
- NCT04427020
- Testing
- Milk protein + GBI-30, Milk protein
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Healthy Participants
The Effects of Commercially Available High Protein Drink on Amino Acid Bioavailability and Recovery From Muscle Fatiguing Exercise in 18-45-year-old Male and Female Participants.
Part A = Purpose of study Part A of the BOLT study will focus on characterising the total and essential amino acid concentrations for 4 hours following the consumption of a single serving of: 1) commercially available…
- Trial name
- BOLT (NCT07497113)
- Testing
- Commercially available high-protein yoghurt drink, Active Comparator: Control drink #1
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Aromatic L-Amino Acid Decarboxylase Deficiency
Prevalence of High Plasmatic 3OMethyldopa Level in a Specific Population of Patients With a Symptomatology Compatible With AADC Deficiency
O-MethyDopa (3-OMD) is a metabolite of the Dopaminergic pathway that accumulates in case of a default in the neurotransmitter biosynthesis due to a key enzyme deficiency: Aromatic L-Amino Acid Decarboxylase (AADC) deficiency.
- Trial name
- DOPADEF (NCT05211609)
- Testing
- Plasmatic 3-O-Methyldopa dosage
- Where
- 2 sites in France
- Volunteers
- 388 people
- Sponsor
- University Hospital, Montpellier
Alkaptonuria
Individualised Gait Modification Strategies in Alkaptonuria Patients
This study evaluates the efficacy of a gait modification intervention using real-time biofeedback on reducing the knee joint loading in Alkaptonuria patients during treadmill walking.
- Trial name
- NCT04142671
- Testing
- Individualised gait modification intervention
- Volunteers
- 30 people
- Sponsor
- Liverpool John Moores University
Neuromuscular Diseases, Neurodegenerative Diseases
Experimentation of a Personalized Physical Self-education Program at Home: Feasibility Study (PROSOL TELEKINECT)
ALCOTRA (Alpes Latines COoperation TRAnsfrontalière) is one of the European cross-border cooperation programmes covering France and Italy and financed by the ERDF (European Regional Development Fund).
- Trial name
- TELEKINECT (NCT05597592)
- Testing
- Feasability of a personalised physical rehabilitation program at home
- Where
- 2 sites in France, Italy
- Sponsor
- Centre Hospitalier Universitaire de Nice
Postprandial Amino Acid Concentrations in Healthy Adults
Amino Acid Concentrations in Serum After Intake of Different Protein Sources
This study assesses the amino acid concentrations in subject serum after intake of different types of proteins. The study is divided in two consecutive sub-studies.
- Trial name
- NCT06153225
- Testing
- Protein products
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Peripheral Arterial Disease
Efficiency, Safety and Portability of Neovasculgen
In 2010, we completed a phase 1 to 2a clinical trial of pCMV-vegf165 in patients with chronic lower limb ischemia (stage 2a to 3 according to Fontaine classification modified by A. V.
- Trial name
- Neovasculgen (NCT03068585)
- Testing
- Neovasculgen (Cambiogeneplasmid)
- Where
- 3 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Artgen Biotech
Urea Cycle Disorder, Organic Acidemia
Systemic Biomarkers of Brain Injury From Hyperammonemia
Ammonia is a waste product of protein and amino acid catabolism and is also a potent neurotoxin. High blood ammonia levels on the brain can manifest as cytotoxic brain edema and vascular compromise leading to intellectual and…
- Conditions
- Urea Cycle Disorder, Organic Acidemia, Maple Syrup Urine Disease, Glutaric Acidemia I
- Trial name
- NCT04602325
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's National Research Institute
Cytomegalovirus Retinitis, HIV Infections
An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access
To provide oral ganciclovir to patients who require maintenance for control of cytomegalovirus (CMV) retinitis, but who lack patent permanent central venous access for long-term administration of intravenous drugs.
- Trial name
- NCT00002135
- Testing
- Ganciclovir
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Sarcopenia
Efficacy of Dietary Supplementation and Physical Activity in Sarcopenic Elderly
This 3 months randomized, double-blind, placebo-controlled supplementation trial tested the hypothesis that nutritional supplementation with whey protein, essential amino acids and vitamin D concurrent with regular, controlled…
- Trial name
- NCT02402608
- Testing
- dietary supplement
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Protein Malabsorption
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract
Rationale: Worldwide, the aging population is increasing. Aging is associated with loss of independence and increased risk of co-morbidity.
- Trial name
- AgingGut (NCT06553794)
- Testing
- Gastroscopy with duodenal mucosal tissue biopsies
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Frail Elderly
Resistance Exercise Training and Amino Acid Leucine Supplementation in Frail Elderly Women
Frailty is a clinical entity associated with an increase in risk for disease and death and becomes more common as people age. Frailty has a strong relationship with the age-related loss of muscle and strength, termed sarcopenia.
- Trial name
- NCT01922167
- Testing
- Leucine, Alanine
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Advanced Gastrointestinal Cancers
Lymphocyte Enhancement in Gastroenteric Oncology
LEGO is single center double-blind randomized trial aimed at testing the efficacy of an essential ammino acid (EAA) supplementation in improving the absolute count of peripheral lymphocytes and the tolerance to chemotherapy in…
- Trial name
- NCT06343272
- Testing
- EAA supplementation
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Heart Failure, Old Myocardial Infarction
Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration
The purpose of this study is to determine the safety and effectiveness of intracoronary infusion of autologous cardiac stem cells in patients with ischemic cardiomyopathy.
- Trial name
- JOKER (NCT03351400)
- Testing
- Stem cells administered to participants
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Sakakibara Heart Institute
Phenylketonuria
Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response
The investigators will investigate the effect of blood phenylalanine on Kuvan responsiveness in the same patients with PKU when their blood phenylalanine concentrations are altered by diet.
- Trial name
- NCT00841100
- Testing
- Kuvan, Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Miami
Periodontitis, Gingivitis and Periodontal Diseases
Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical Therapy
# Brief Summary (Word count: 198) This combined observational and interventional study investigates salivary amino acid profiles and their connections to periodontal conditions, as well as how these substances change after…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Periodontal Debridement, Periodontal Attachment Loss
- Trial name
- FAA-CP-SRP (NCT07669233)
- Testing
- Non-surgical periodontal therapy
- Where
- China
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Zhang, Yuwei
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