Clinical trials: Amino Acids
Urea Cycle Disorder
A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders
This is an open-label study consisting of a transition period to RAVICTI, followed by a safety extension period for at least 6 months and up to 24 months of treatment with RAVICTI, depending on age at enrollment.
- Trial name
- NCT02246218
- Testing
- RAVICTI
- Where
- 17 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- Amgen
Cirrhosis, Liver
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
Loss of skeletal muscle mass or sarcopenia is the most common and potentially reversible complication in cirrhosis that increases morbidity and mortality before, during and after liver transplantation.
- Trial name
- NCT03208868
- Testing
- Leucine enriched essential amino acid (EEA/LEU), Balanced amino acid supplement (BAA)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Exercise-induced Delayed Onset Muscle Soreness
Branched Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College Females
The purpose of this study is to determine if a dietary supplement containing branched chain amino acids will reduce the muscle soreness that sometimes occurs in the days following exercise.
- Trial name
- NCT01781910
- Testing
- Branched Chain Amino Acid drink supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Healthy
Metabolic Availability of Lysine From Barley in Young Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03907020
- Testing
- Barley
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Traumatic Brain Injury
Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study
Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage.
- Trial name
- NCT00205582
- Testing
- Positron Emission Tomography
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Sarcopenia
Efficacy of Dietary Supplementation and Physical Activity in Sarcopenic Elderly
This 3 months randomized, double-blind, placebo-controlled supplementation trial tested the hypothesis that nutritional supplementation with whey protein, essential amino acids and vitamin D concurrent with regular, controlled…
- Trial name
- NCT02402608
- Testing
- dietary supplement
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Fractional Zinc Absorption
Determination of Pre-Absorptive Dissociation of Zinc From a Zinc Amino Acid Complex in Healthy Men
Zinc may be absorbed from diet via zinc transporter mediated pathways, or, when coupled with amino acids, via amino acid transporter pathways.
- Trial name
- NCT03934346
- Testing
- Zinc amino acid complex
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Pressure Ulcer
The Use of Specialised Amino Acid Mixture in Pressure Ulcer Wound Healing Rates- A Placebo Controlled Trial
This research aims to address the gap in the studies done and test the effects of a commercial mixture of 7 g of Arginine, 7 g Glutamine and 1.2 g HMB* twice a day on hard to heal pressure ulcers in an Asian patient cohort in an…
- Trial name
- NCT01090076
- Testing
- Abound (7 g of Arginine, 7 g Glutamine and 1.2 g HMB)
- Where
- Singapore
- Volunteers
- 26 people
- Sponsor
- Changi General Hospital
Healthy
Nutrient Regulation of Amino Acid Transporters in Aging Human Skeletal Muscle
The goal of the research project is to determine how aging and inactivity reduce the muscle anabolic effect of nutrients and lead to muscle and functional loss.
- Trial name
- NCT01669590
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hepatic Steatosis, NAFLD
Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)
Participants 13-18 years of age with extra fat stored in the liver will be randomly assigned to a protein supplement or placebo "fake supplement" for 2 months to see if the participants who get the protein supplement have less…
- Conditions
- Hepatic Steatosis, NAFLD, Adolescent Obesity
- Trial name
- AMINOS (NCT05935826)
- Testing
- Essential Amino Acid Supplement by Amino Co
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Colorado, Denver
Phenylketonurias
Effects of Synergy on Nutrient Intake and Acceptability in Phenylketonuria (PKU)
Phenylketonuria (PKU) is a rare inherited metabolic disorder, where subjects are born with a genetic deficiency in the phenylalanine hydroxylase enzyme (PAH), which leaves them unable to convert Phenylalanine (Phe) into Tyrosine…
- Trial name
- ESSENTIAL (NCT03777826)
- Testing
- PKU Synergy
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 13 people
- Sponsor
- Nutricia Research
Muscle Protein Synthesis
Re-evaluation of the Muscle-full Effect During Continuously Elevated Amino Acid Availability in Healthy Young Males
Muscle tissue consists of proteins. These proteins are built up of a collection of smaller building blocks: amino acids. When protein is consumed, it gets digested and absorbed into the blood.
- Trial name
- Muscle-full (NCT06721026)
- Testing
- Continuous intravenous stable isotope amino acid tracer infusion, Amino acid infusion
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Malabsorption
Enteral Nutrition and Amino Acid Absorption
The purpose of this study is to evaluate amino acid absorption with two different type of proteins.
- Trial name
- PEPS (NCT02590120)
- Testing
- Enteral nutrition
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Société des Produits Nestlé (SPN)
Sarcopenia
PET/CT of Skeletal Muscle Amino Acid Kinetics
Our goal is to develop and test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.
- Trial name
- NCT01698424
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Increased Metabolic Requirements
Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique
Masters level cyclists are a population above the age of 35 years who frequently participate in prolonged as well as heavy-volume training.
- Conditions
- Healthy, Increased Metabolic Requirements, Dietary Reference Intakes
- Trial name
- NCT06431334
- Testing
- Amino Acid Intake
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McGill University
Cytomegalovirus Retinitis, HIV Infections
The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
The use of ganciclovir (DHPG) in combination with interferon beta to prevent relapse of cytomegalovirus retinitis in patients with AIDS.
- Trial name
- NCT00002299
- Testing
- Interferon beta-1b, Ganciclovir
- Where
- 6 sites in United States
- Sponsor
- Hoffmann-La Roche
Rate of Water Appearance/Delivery in the Blood Water Balance
Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids (2859)
To determine the effects of a moderate amount of amino acids on the rate of water absorption and availability as a precursor fluid for sweat.
- Trial name
- NCT05698849
- Testing
- Composition of Sports Drink
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Fovea Plana, Albinism
Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population
Albinism is a genetic condition, resulting from mutations in at least 19 known genes responsible for the production of melanin in the skin, hair and eyes. Ophthalmological manifestations are a constant feature of this disease.
- Trial name
- APOGEE (NCT04658381)
- Testing
- Genetic analysis, Ophthalmologic exam
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Environmental Enteric Dysfunction
Indispensable Amino Acids Bioavailability in Children With Environmental Enteropathy Dysfunction (IAA-EED)
In Morocco, large efforts have been made to enhance nutritional status and health conditions of children. Accordingly, stunting was reduced and the prevalence of stunting have decreased from 28,6% in 1987 to 14,9% in 2011.
- Trial name
- IAA-EED (NCT07256028)
- Testing
- Indispensable amino acids supplemntation, Without Indispensable amino acids supplementation
- Where
- Morocco
- Volunteers
- 40 people
- Sponsor
- Morocco's National Centre for Energy, Sciences and Nuclear Techniques
Heart Failure
Resistance Exercise Program and Branched Chain Amino Acid Supplementation in Heart Failure Patients
Heart Failure (HF) is a complex syndrome which can include the physiological, neural hormonal and metabolic complications known as "Cardiac Cachexia" (CC).
- Trial name
- NCT02240511
- Testing
- RE and BCAA Supplementation, Resistance Exercise
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
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