Clinical trials: Amino Acids
Methylmalonic Acidemia, Propionic Acidemia
Understanding the Long-Term Management of Organic Acidemia Patients With CARBAGLU®: A Mixed Methods Approach
This is a prospective mixed-design study focused on the long-term management of propionic aciduria (PA) and methylmalonic aciduria (MMA) with N-carbamylglutamate (NCG) maintenance therapy.
- Trial name
- PROTECT (NCT04176523)
- Testing
- Carglumic Acid
- Where
- 32 sites in France, Germany and 5 more
- Volunteers
- 95 people
- Sponsor
- RECORDATI GROUP
Protein Requirement of Athletes
Measuring Protein Requirement Using Amino Acid Oxidation in Strength and Endurance Athletes
Our objective is to determine the dietary requirement of protein for strength and endurance exercise trained (more than 4 months training experience) individuals between 18 - 30 years of age using the indicator amino acid…
- Trial name
- NCT02621294
- Testing
- Measuring protein requirement
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Phenylketonurias
Early Dietary Treated Patients With Phenylketonuria Can Achieve Normal Growth and Mental Development.
The study aim is to follow up body growth(body weight by kg, length by cm, head circumference, abdominal circumference, and body mass index ) and mental development of infants on phenylalanine restricted diet in comparison with…
- Trial name
- NCT04302194
- Testing
- phenylalanine restricted diet
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Kwashiorkor
Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor
This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiorkor type of malnutrition and whether…
- Trial name
- NCT00429351
- Where
- Jamaica
- Volunteers
- 82 people
- Sponsor
- Baylor College of Medicine
Allergy Milk
Step Down Approach in Children With Cow Milk Allergy
Cow's milk allergy (CMA) affects up to 3% of European children. In the absence of an alternative to cow's milk, the management of CMA is based on the use of safe, affordable and nutritionally adequate formulas.
- Trial name
- SDACMA (NCT03449537)
- Testing
- extensively hydrolyzed casein formula + LGG, Hypoallergenic formula based on amino-acid based formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Healthy Volunteers
Bioavailability of Different Collagen-based Treatments After Oral Intake
The goal of this clinical trial is to investigate the postprandial absorption of collagen and elucidate the absorption rate and bioavailability after oral intake of collagen-based products.
- Trial name
- NCT05722158
- Testing
- Dietary supplementation with the collagen-based product CP1., Dietary supplementation with the collagen-based product CP2., Dietary supplementation with the collagen-based product CP3.
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Post-surgical Oral Wounds, Oral Cavity Surgery
Evaluation of the Performance and Safety of a Linear Hyaluronic Acid-Based Medical Device in the Treatment of Surgical Wounds in the Oral Cavity.
The PR-DENT study is an interventional, single-center, controlled clinical investigation aimed at evaluating the clinical performance and safety of a Class III medical device based on linear hyaluronic acid for the treatment of…
- Conditions
- Post-surgical Oral Wounds, Oral Cavity Surgery, Wound Healing/Regeneration, Dental Extraction Sites
- Trial name
- PR-DENT (NCT07421934)
- Testing
- Intervention: Linear Hyaluronic Acid (Gumblast), Control: Standard Surgical Procedure
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- The Wave Innovation Group s.r.l.
Phenylketonurias
Safety and Efficacy Study of NGGT002 in PKU Adult Subjects
This is a single-center, open-label, non-randomized, dose escalation study to evaluate the safety, tolerability and efficacy of NGGT002 in adult Phenylketonuria (PKU) subjects.
- Trial name
- NCT06061614
- Testing
- NGGT002 Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- The First Affiliated Hospital of Bengbu Medical University
End Stage Renal Disease (ESRD)
Evaluate the Efficacy and Safety of Amino Acid (15) Peritoneal Dialysis Solution in Peritoneal Dialysis Patients with Malnutrition.
This is a multicenter, randomized, parallel controlled Phase IV clinical study to evaluate the safety and efficacy of amino acid (15) peritoneal dialysis solution in patients undergoing peritoneal dialysis with malnutrition in…
- Trial name
- NCT06597201
- Testing
- amino acid (15) peritoneal dialysis solution, glucose peritoneal dialysis solution
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Chengdu Qingshan Likang Pharmaceutical Co., Ltd
Amino Acid Change, Food Science
The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule
This study aims to understand how the Milk Protein Concentrate/Fast Protein (MCP/FP) investigational product (IP) compares to a control the Micellar Casein Isolate/Slow Protein (MCI/SP) product in healthy volunteers.
- Conditions
- Amino Acid Change, Food Science, Nutrition, Digestion Rate
- Trial name
- NCT06394687
- Testing
- Milk Protein Concentrate, Micellar Casein Isolate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Lactation, Breastfeeding, Exclusive
Lysine Requirements During Lactation
The study aims to establish lysine requirements using the indicator amino acid oxidation (IAAO) method in women exclusively breastfeeding a single infant aged 3-4 months, and how maternal lysine needs change once infant…
- Conditions
- Lactation, Breastfeeding, Exclusive, Breastfeeding
- Trial name
- NCT06366204
- Testing
- Dietary Lysine Intakes
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Phenylketonuria, Hyperphenylalaninaemia
PKUDOS: Phenylketonuria (PKU) Demographic, Outcomes, and Safety Registry
The objective of this study is to evaluate the safety of long-term treatment with Kuvan.
- Trial name
- PKUDOS (NCT00778206)
- Testing
- Kuvan
- Where
- 45 sites in United States
- Volunteers
- 1,887 people
- Sponsor
- BioMarin Pharmaceutical
Sports Nutrition, Protein Supplementation
Acute Whey Protein And Casein Supplementation: Effect On Protein Metabolism After Resistance Exercise
The proteins of human breast milk are the most important endocrine signaling system that promotes neonatal growth by increasing the release of insulin, insulin-like growth factor-1 (IGF-1), and the leucine-mediated mammalian…
- Trial name
- NCT04648384
- Testing
- Blend Protein Supplementation, Resistance Exercise
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Phenylketonurias
Study to Evaluate the Response to and Safety of an 8-Day Course of Phenoptin™ Treatment in Subjects With Phenylketonuria
The primary objective is to evaluate the degree and frequency of response to Phenoptin™ (sapropterin dihydrochloride), as demonstrated by a reduction in blood phenylalanine (Phe) level among subjects with phenylketonuria (PKU)…
- Trial name
- NCT00104260
- Testing
- sapropterin dihydrochloride
- Where
- 13 sites in United States
- Volunteers
- 700 people
- Sponsor
- BioMarin Pharmaceutical
Mitochondrial Disease, Chronic Metabolic Disorder
Energy Requirements in Mitochondrial Disease
Metabolic diseases and mitochondrial disorders are caused by genetic mutation which lead to disruptions in energy producing pathways in our body.
- Trial name
- NCT01776918
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University of British Columbia
Phenylketonurias
Safety and Tolerability of RTX-134 in Adults With Phenylketonuria
This study will evaluate the safety and tolerability of RTX-134 in adult patients with PKU.
- Trial name
- NCT04110496
- Testing
- RTX-134
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rubius Therapeutics
Morbid Obesity, Bariatric Surgery Candidate
Preoperative Condition in Giant Obese Patients
The frequency of super-super obese who need immediate weight loss surgery is risen continuously. For those patients a prior-to-surgery conditioning therapy is mandatory to gain technical and physical operability.
- Trial name
- NCT02616003
- Testing
- Liraglutide, Aminosteril hepa 8%, Caloric diet with 1000 kcal
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
Lumbar Spinal Stenosis
Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial
The goal of this clinical trial is to prospectively evaluate the effects of essential amino acid (EAA) supplementation on the volume and structure of the muscles surrounding the spine (paraspinal musculature).
- Trial name
- NCT06579391
- Testing
- Essential amino acids, Alanine
- Where
- United States
- Sponsor
- University of California, Irvine
Insulin Resistance, Colorectal Cancer
Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.
Postoperative insulin resistance refers to the phenomenon that the body's glucose uptake stimulated by insulin is reduced due to stress effects such as trauma or the inhibitory effect of insulin on liver glucose output is…
- Trial name
- NCT05494658
- Testing
- BCAA, water
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sun Peng
Phenylketonuria (PKU)
Brain Aging in Phenylketonuria
Background: Historically, the primary goal in managing phenylketonuria (PKU) has been to prevent severe and irreversible intellectual disability, as well as to address nutritional deficiencies that could lead to growth…
- Trial name
- NCT06969209
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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