Clinical trials: Amitriptyline
Diabetic Neuropathy, Painful
Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain
This study is to compare the tolerability of different methods for switching from another medication to duloxetine for the management of diabetic nerve pain.
- Trial name
- NCT00266643
- Testing
- duloxetine hydrochloride
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 205 people
- Sponsor
- Eli Lilly and Company
Burning Mouth Syndrome, Stomatodynia
Topical Amitriptyline 1% Gel for the Treatment of Burning Mouth Syndrome
Burning mouth syndrome (BMS) is a chronic oral pain condition that causes a persistent burning or stinging sensation in the mouth, often without visible changes in the tissues.
- Trial name
- TOP-AMI → TOPi (NCT07214181)
- Testing
- Topical amitriptyline 1% gel
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Thermal Burn, Amitriptyline
Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). Studies suggest these MVP are involved in many conditions such as after the thermal burn injury.
- Trial name
- NCT07716722
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wright State University
Cancer, Neuralgia
Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
Rationale: Often, incurable cancer patients suffer from severe symptoms as (neuropathic) pain and fatigue with polypharmaceutic interventions as a consequence.
- Trial name
- Off-label (NCT00740571)
- Testing
- amitriptyline, pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 130 people
- Sponsor
- Radboud University Medical Center
Functional Gastrointestinal Disorders
Study of Medication for Functional Abdominal Pain in Children
The purpose of this study is to determine where amitriptyline is effective in the treatment of functional abdominal pain in children.
- Trial name
- NCT00564525
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Functional Dyspepsia
Effect of Amitriptyline and Trifluoperazine on Patients With Functional Dyspepsia
The goal of this clinical trial is to assess and compare the effect of amitriptyline and trifluoperazine in improving dyspeptic symptoms in patients with functional dyspepsia.
- Trial name
- NCT07008235
- Testing
- Tablet Amitriptyline 10 milligrams, Tablet Trifluoperazine 1 milligrams twice daily, Standard First-Line Therapy
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Md. Moktadirul Hoque Shuvo
Irritable Bowel Syndrome With Diarrhea
To Compare the Efficacy of Drugs in Combination for Treating Irritable Bowel Syndrome Associated With Diarrhea
The goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (IBS)-associated diarrhea.
- Trial name
- NCT05867550
- Testing
- Rifaximin 550 MG, Mebeverine 135 MG, Psyllium Husk
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Bahria University
Adverse Drug Events, Adverse Drug Reactions
YouScript IMPACT Registry
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized…
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- IMPACT (NCT02191358)
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Genelex Corporation
Chronic Pain
Genetic Determinants of Amitriptyline Efficiency for Pain Treatment - Part II
Low dose tricyclic antidepressant drugs are routinely administered co-analgesics in pain medicine. Amitriptyline is largely considered as a gold standard. Amitriptyline underlies cytochrome CYP2D6 and CYP2D19 metabolism.
- Trial name
- NCT02256956
- Testing
- Amitriptyline, Tolterodine
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Migraine
Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis
The goal of this clinical trial is to compare the efficacy and safety of Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis in outddor migraine patients attending headache clinic.
- Trial name
- NCT05759845
- Testing
- Topiramate 25Mg Tab, Amitriptyline 25 Mg Oral Tablet, topiramate 25mg plus amitriptyline 25mg
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Dr. Reaz Mahmud
Irritable Bowel Syndrome
Colonoscopy-related Pain Predicts the Treatment Response of Amitriptyline in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a functional bowel disorder with recurrent abdominal pain and disordered defecation and is one of the most common gastrointestinal problems.
- Trial name
- NCT02638870
- Testing
- Amitriptyline
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Samsung Medical Center
Pain
Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents
The objective of the study is to compare the efficacy of gabapentin and amitriptyline for treating neuropathic pain in children in a randomized controlled trial.
- Trial name
- NCT00312260
- Testing
- Gabapentin, Amitriptyline
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Diarrhea- Predominant Irritable Bowel Syndrome, Quality of Life
Effects of Mesalamine and Amitriptyline on Irritable Bowel Syndrome
The aim of this study is to evaluate the effects of Mesalamine and Amitriptyline drugs on the Quality of Life and Symptom Severity Scale in patients with Diarrhea- Predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- NCT02190526
- Testing
- Mesalazine(asacol 800 mg), Amitriptyline
- Where
- Iran
- Sponsor
- Tehran University of Medical Sciences
Myofacial Pain
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain
The purpose of the study is comparing two drugs efficacy for the treatment of pain originates from masticatory muscles. The two drugs are - Amitriptlyne (amitriptyline) and Gabapentin (gabapentin), both of them are common use in…
- Trial name
- NCT02339662
- Testing
- Gabapentin, Amitriptyline
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Doron Aframian
Chronic Oral Food Refusal
Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Gastrojejunal (G-J) feeding tubes are placed in infants and children who refuse to eat or are unable to eat enough to have normal growth.
- Trial name
- NCT01206478
- Testing
- Amitriptyline, Megestrol
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ann Davis, PhD, MPH, ABPP
Unipolar Depression
Amitriptyline and Paroxetine Treatment of Major Depression
Activation of the hypothalamus-pituitary-adrenal system is monitored using saliva cortisol sampling during the antidepressant treatment with amitriptyline and paroxetine in moderately to severely depressed patients.
- Trial name
- NCT01049347
- Testing
- amitriptyline, paroxetine
- Where
- Germany
- Volunteers
- 127 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Pain, Neuropathic, Leprosy
Treatment of Neuropathic Pain in Leprosy
Despite large efforts to eradicate leprosy, this curable mycobacterial infection still affects 250,000 new individuals annually. Half of the globe's leprosy patients live in Brazil and India.
- Conditions
- Pain, Neuropathic, Leprosy, Leprosy Neuropathy, Amitriptyline
- Trial name
- AmyNeLe (NCT03324035)
- Testing
- Amitriptyline, Tramadol
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- University of Sao Paulo
Low Back Pain
A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol
Non inferiority, multicentric, double blind study whose the primary objective is to compare the effectiveness of two products in pain reduction.
- Trial name
- NCT01421433
- Testing
- Tandrilax, Dolamin Flex
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Farmoquimica S.A.
Neck Pain
Low Doses Amitriptyline & Chronic Neck Pain
The objective of this prospective randomized and controlled study is to evaluate the efficacy and safety of low dose of amitriptyline (5 mg) in the management of chronic neck pain.
- Trial name
- NCT01561209
- Testing
- Amitryptiline
- Where
- Lebanon
- Volunteers
- 212 people
- Sponsor
- St Joseph University, Beirut, Lebanon