Clinical trials: Amniotic Fluid; Disorder
Premature Rupture of Membrane, Amniotic Fluid Leakage
The Impact of Amniotic Fluid Index (AFI) on Maternal and Perinatal Outcomes in Pregnant Women With Preterm Premature Rupture of Membranes
Pregnant women who admitted with the complaint of amniotic fluid leakage between the gestational ages of 23+0 and 33+0 and who finally were diagnosed as PPROM were included in the study.
- Conditions
- Premature Rupture of Membrane, Amniotic Fluid Leakage, Maternal Complication of Pregnancy, Fetal Complications
- Trial name
- AFI in PPROM (NCT04100252)
- Testing
- AFI via transabdominal ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul Medeniyet University
Lumbar Spinal Stenosis
Sterile Amniotic Fluid Filtrate Epidural Injection.
There is a large population of patients with lumbosacral radicular pain due to spinal stenosis who do not respond to physical therapy or oral medication management, yet wish to avoid spinal surgery or are simply not candidates…
- Trial name
- NCT04537026
- Testing
- Amniotic Fluid Allograft, Dexamethasone sodium phosphate
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Utah
Lung Diseases, Interstitial
Nebulized Human Amniotic Fluid in Patients With Interstitial Lung Disease
This is a Phase I, pilot clinical trial designed to evaluate the safety and exploratory efficacy of nebulized diluted amniotic fluid, Matrix (HAF-Matrix) in adults with interstitial lung disease (ILD).
- Trial name
- HAF ILD (NCT07372989)
- Testing
- Matrix
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maule Stem Cell Research Institute, Inc.
Meconium-stained Amniotic Fluid, Chorioamnionitis
Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. Placebo
Our randomized controlled double blind clinical trail aims to compare maternal and neonatal infectious morbidity between women with meconium-stained amniotic fluid treated with zinacef vs. placebo.
- Trial name
- NCT06849037
- Testing
- zinacef tretment
- Where
- Israel
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Hair Thinning
Pilot Study to Evaluate the Efficacy and Safety of Xvie Delivered Into the Scalp by Microneedling in Women With Self-perceived Thinning Hair
The goal of this study is to determine how safe and effective it is to improve hair growth using XVIE solution applied on the scalp of women with self-perceived thinning hair. The main aims of this trial are: 1.
- Trial name
- NCT07221773
- Testing
- XVIE
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Restore Biologics Holdings, Inc. dba Xtressé
Retained Fetal Lung Fluid
Accuracy of Amniotic Fluid Lamellar Body Counting for Evaluating of Fetal Lung Maturity
The purpose of this study is to determine the accuracy of Amniotic fluid Lamellar Body Counting for Evaluating of Fetal Lung Maturity.
- Trial name
- NCT01463722
- Testing
- Amniotic fluid Lamellar Body Counting
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Oligohydramnios, Amniotic Fluid; Disorder
Effect of Intermittent Pneumatic Compression Device of Lower Limbs in Oligohydramnios
the study will examine the effect of application of intermittent pneumatic pressure device on lower limbs on the amniotic fluid amount and fetal doppler indices in women with oligohydramnios
- Trial name
- NCT05474326
- Testing
- intermittent pneumatic pressure device (Kendall SCD™ 700 Smart Compression™ System)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Neural Tube Defects
Metals/Vitamins Levels in NTD
Introduction: Heavy metals important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies.
- Trial name
- NTD&HMs (NCT04523233)
- Testing
- Amniocentesis
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Meconium Aspiration Syndrome
Interleukin-6 in the Development of Meconium Aspiration Syndrome in Newborn
This trial is intended to assess the serum levels of interleukin-6 as a predictive factor for the occurrence of meconium aspiration syndrome in infants born with MSAF.
- Trial name
- NCT07394322
- Testing
- serum interleukin 6
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Ocular Graft Versus Host Disease
Study for the Treatment of Ocular Chronic Graft-Versus-Host Disease (GVHD) With Amniotic Fluid Eye Drops (AFED)
A Randomized, Double-blinded, Placebo-Controlled Study for the Treatment of Ocular Chronic Graft Verses Host Disease with Processed Amniotic Fluid (pAF) Drops.
- Trial name
- NCT03298815
- Testing
- Amniotic Fluid Eye Drops (AFED), Saline Solution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Oligohydramnios
The Added Contribution of Transvaginal Sonographic Evaluation of Amniotic Fluid Index
The current study is based on the use of transvaginal sonography in the evaluation of oligohydramnios. Patients will be recruited after amniotic fluid index evaluation according to transabdominal sonography.
- Trial name
- NCT03935607
- Testing
- Transvaginal sonography
- Where
- Israel
- Volunteers
- 350 people
- Sponsor
- Rambam Health Care Campus
SARS CoV-2 Infection
A Pilot Study of Human Amniotic Fluid for COVID19 Associated Respiratory Failure
The purpose of this study is to test the effect of purified (acellular) amniotic fluid as a treatment for SARS CoV-2 (COVID19)-associated respiratory failure.
- Trial name
- NCT04319731
- Testing
- Human Amniotic Fluid
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Cytomegalovirus Infections
Genotyping of Cytomegalovirus From Patients in Israel
The researchers select 100 cytomegalovirus (CMV) DNA samples from patients diagnosed with CMV infection. Patients include bone marrow transplant patients, pregnant women and newborns.
- Trial name
- NCT00228202
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes
Although much investigation has been done on the use of ferning in the second and third trimesters, particularly with the development of rapid protein clinical assays, there appears to be lower ferning rates in clinical practice…
- Trial name
- NCT04963465
- Testing
- Ferning on microscopy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albany Medical College
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
Premature Rupture of Membrane
The Use of Quantitative Pregnancy Test in Amniotic Fluid as a Diagnostic Tool for Rupture of Fetal Membranes
Two groups will be recruited. The first group are pregnant ladies that have unequivocal rupture of fetal membranes that is diagnosed by seeing the amniotic fluid leakage in the vagina.
- Trial name
- NCT03106311
- Testing
- assessment of beta subunit of human chorionic gonadotropin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Necrotizing Enterocolitis
Simulated Amniotic Fluid Solution in Neonates Recovering From GIT Surgeries
Amniotic fluid plays a significant role in fetal gut maturation and development. The human fetus swallows over 200 ml of amniotic fluid per kilogram of weight each day and such swallowing is essential for normal small bowel…
- Trial name
- NCT03302338
- Testing
- SAFE group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Rania Ali El-Farrash
Amniotic Fluid Leakage
Pivotal Study of the Al-Sense Study Protocol
The purpose of this study is to demonstrate that the Diagnostic Absorbent Panty liner (AL-SENSE Amniotic Leak Test Kit), developed by Common Sense Ltd., can distinguish between wetness sensed by pregnant women that is caused by…
- Trial name
- NCT00604838
- Testing
- AL-SENSE Diagnostic Absorbent Panty liner
- Where
- 2 sites in United States, Israel
- Volunteers
- 330 people
- Sponsor
- Western Galilee Hospital-Nahariya
Congenital Diaphragmatic Hernia
Proteomic Profiling for Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is a severe congenital malformation, related to a developmental defect of the diaphragm. The incidence of CDH is approximated at 1 in 3,000 live births.
- Trial name
- pro-CDH (NCT03179371)
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Fetal Growth Retardation
Doppler and AFV for Outcome Prediction ın FGR
The investigator contrived a prospective study of AUCR to compare its association to adverse perinatal outcomes with other established doppler parameters, such as CPR and UCR within a population of suspected FGR fetuses at term.
- Trial name
- NCT05295667
- Testing
- Doppler measurement in combination with amniotic fluid volume
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital