Clinical trials: Amorphous, Eosinophilic, and Acellular Deposit
Alzheimer's Disease
Implications of Amyloid Pathology
The purpose of this study is to determine whether asymptomatic older individuals with high amyloid burden will subsequently manifest cognitive impairment and eventually progress to clinical Alzheimer's Disease (AD).
- Trial name
- NCT00900770
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
AD, DM
The Mechanism Study of Diabetic Pancreatic Amyloid Deposition on Cognitive Dysfunction in Alzheimer's Disease
Alzheimer's disease (AD) is closely related to diabetes (DM). DM will aggravate the progression of AD, but the specific mechanism has not yet been clarified.
- Conditions
- AD, DM, PET-CT
- Trial name
- NCT05372458
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Alzheimer's Disease
Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants
Study to understand factors related with the preclinical stages of Alzheimer's Disease and investigate markers that predict its progression.
- Trial name
- NCT02685969
- Testing
- 18F-Flutemetamol & 18F-FDG
- Where
- Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Multiple Myeloma, Myeloma-Associated Amyloidosis
Selinexor and Lenalidomide for Consolidation and Maintenance Treatment in Multiple Myeloma Post-transplant
This phase II clinical trial studies the addition of selinexor to lenalidomide in patients with multiple myeloma following transplant.
- Trial name
- NCT05820763
- Testing
- Selinexor, Lenalidomide, Dexamethasone
- Sponsor
- Washington University School of Medicine
Down Syndrome
Natural History of Amyloid Deposition in Adults With Down Syndrome
The primary objective of this study is to assess the presence of amyloid in non-demented/functionally stable adults with DS as a function of age, dividing the sample into amyloid-positive and amyloid-negative groups.
- Trial name
- NCT01303133
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer's Disease
Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease
Glucose is the main energy source of brain. Different neural degenerative diseases such as Parkinson's disease or Alzheimer's disease have shown distinct brain glucose metabolic patterns.
- Trial name
- NCT04174287
- Testing
- F-18-AV45
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects
A second-generation tau PET image tracer 18F-PM-PBB3 (APN-1607 or MNI-958) has been developed by National Institute of Radiological Sciences. The new tracer solved the off-target binding issue.
- Trial name
- NCT04169126
- Testing
- F-18 PMPBB3
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment
Facilitating Optimal Routines in Aging
Loss of cognitive abilities leading to Alzheimer's disease is progressive and destructive, leaving older adults disabled and unable to recall their past.
- Trial name
- ForAging (NCT03913637)
- Testing
- Strategy Training, Enhanced Usual Care
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Pittsburgh
Amorphous, Eosinophilic, and Acellular Deposit, Constipation
S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis
This phase II trial studies how well isatuximab works in treating patients with primary amyloidosis that has come back or does not respond to treatment.
- Conditions
- Amorphous, Eosinophilic, and Acellular Deposit, Constipation, Diarrhea, Early Satiety
- Trial name
- NCT03499808
- Testing
- Isatuximab, Laboratory Biomarker Analysis
- Where
- 345 sites in United States
- Volunteers
- 43 people
- Sponsor
- SWOG Cancer Research Network
Cognitive Impairment, Carotid Artery Plaque
The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition
The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain…
- Conditions
- Cognitive Impairment, Carotid Artery Plaque, Inflammation
- Trial name
- NCT03068442
- Testing
- Imaging with flutemetamol F 18 PET/CT
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Scott Mcnally