Clinical trials: Amphetamine Use Disorders, open to volunteers
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH
Opioid Use Disorder, Severe, Amphetamine Use Disorder
Applying Low-Intensity Focused Ultrasound in Treating Severe Substance Use Disorder: Tolerability and Effectiveness
The goal of this clinical trial is to investigate the safety and efficacy of applying low-intensity focused ultrasound targeting the nucleus accumbens in individuals with opioid or amphetamine use disorders.
- Trial name
- NCT07734623
- Testing
- Low-intensity focused ultrasound, false stimulus
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Amphetamine Use Disorders
Closed-loop tTIS Targeted of the Nac as an Intervention for MUD Patients
Closed-loop transcranial temporal interference stimulation (tTIS) targeting the nucleus accumbens may modulate abnormal neural responses to drug-related cues in individuals with methamphetamine use disorder (MUD), thereby…
- Trial name
- NCT07802223
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Mental Health Center
Amphetamine Use Disorders, Amphetamine Use Disorder
Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders
Amphetamine Use Disorder (AUD) is a major public health issue in Taiwan, where it is the most commonly abused illegal drug. There are currently no effective approved medications to treat it, which makes finding new treatment…
- Conditions
- Amphetamine Use Disorders, Amphetamine Use Disorder, Amphetamine Dependence, Amphetamine Abuse
- Trial name
- NCT06960265
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- TsaoTun Psychiatric Center, Department of Health, Taiwan
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre
Cocaine Use Disorder
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD).
- Trial name
- NCT05011760
- Testing
- Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rajesh Narendran
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Post Traumatic Stress Disorder
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms…
- Trial name
- NCT05790239
- Testing
- 3,4-methylenedioxymethamphetamine, d-amphetamine, Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Stephen Robert Marder