Clinical trials: Ampulla of Vater Adenoma
Duodenum Cancer, Familial Adenomatous Polyposis
Duodenal Polyposis Classification in FAP
Duodenal cancer is the leading cause of cancer-related mortality in patients with familial adenomatous polyposis (FAP), yet the current Spigelman staging system provides limited predictive accuracy for advanced neoplasia.
- Conditions
- Duodenum Cancer, Familial Adenomatous Polyposis, Duodenal Polyposis, Ampulla of Vater Adenoma
- Trial name
- DRACO (NCT07199127)
- Testing
- DRACO
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Ampullary Adenoma
Endoscopic Resection of Papillary Adenomas; a Novel Treatment Algorithm to Prevent Recurrence - a Pilot-study
Recurrence after endoscopic papillectomy is described in up to 33% of the cases (range 12-33%). This leads to re-interventions, a cumulative risk of adverse events, and the need for long-term follow-up.
- Trial name
- ERASE (NCT06216730)
- Testing
- Endoscopic papillectomy
- Volunteers
- 20 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ampulla of Vater Intestinal-Type Adenoma
The Use of Cap-assisted Forward Viewing Endoscopy for Examination of the Ampulla of Vater
The aim of this study is to compare the visualization rates of the ampulla of Vater using forward- viewing endoscopes with or without cap attached to the distal end in the same patient.
- Trial name
- NCT02867826
- Testing
- Cap
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Ampulla of Vater Adenoma
Comparison on the Efficacy of Endoscopic Snare Papillectomy With or Without Submucosal Injection
Because the ampulla of Vater is strategically located at the confluence of the pancreatic and common bile ducts, endoscopic resection of papillary neoplasms may be technically different from endoscopic mucosal resection in other…
- Trial name
- NCT02165852
- Testing
- Papillectomy without injection, Papillectomy with injection
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Soon Chun Hyang University
Ampulla of Vater Adenoma, Ampulla of Vater Disease (Benign/Malignancy)
Predictors of Therapeutic Success and Adverse Events in Endoscopic Ampullectomy
Although ampullary tumors are rare (representing 0.6-0.8 % of all digestive cancers), their estimated incidence has increased in recent years (<1 per 100 000 per year).
- Trial name
- NCT06648746
- Volunteers
- 100 people
- Sponsor
- Universidade do Porto
Duodenal Diseases
Endoscopic Characteristics of Duodenal and Ampullary Lesions
The purpose is to investigate whether polyps that look different at endoscopy, have formed via different mutations and have different risks of turning into cancer.
- Trial name
- DUO/AMP-LST (NCT01556399)
- Testing
- Tissue Sampling
- Where
- Australia
- Volunteers
- 350 people
- Sponsor
- Professor Michael Bourke
Ampulla of Vater Neoplasms, Ampullary Adenoma
Effect of Negative-Pressure Drainage Versus Pancreatic Duct Stenting for Preventing Pancreatitis After Endoscopic Papillectomy for Duodenal Papillary Tumors
This prospective, multicenter, randomized controlled trial aims to evaluate the effectiveness of negative-pressure duodenal drainage compared with prophylactic pancreatic duct stenting in preventing post-endoscopic papillectomy…
- Conditions
- Ampulla of Vater Neoplasms, Ampullary Adenoma, Ampullary Carcinoma
- Trial name
- NCT07446543
- Testing
- Placement of a negative pressure drainage tube, Placement of a pancreatic duct stent
- Volunteers
- 132 people
- Sponsor
- Cui Xiaobing
Ampullary Adenoma, Ampulla of Vater Adenoma
Efficacy and Safety of Endoscopic Papillectomy in the Treatment of Ampullary Neoplasms.
The aim of our study is to provide data on the efficacy and safety of endoscopic papillectomy, by including consecutive patients treated after 2015, when first guidelines on endoscopic management of ampullary neoplasms were…
- Conditions
- Ampullary Adenoma, Ampulla of Vater Adenoma, Ampullary Cancer, Ampulla of Vater Cancer
- Trial name
- PaNETh (NCT05690412)
- Testing
- Endoscopic Papillectomy
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Post-Procedural Complications
Biliary Plus Pancreatic Stent vs Pancreatic Stent Alone After Endoscopic Papillectomy
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the safety and efficacy of biliary stent placement combined with pancreatic stent placement versus pancreatic stent alone in…
- Trial name
- NCT07891715
- Testing
- Endoscopic papillectomy with pancreatic duct stent placement, Endoscopic papillectomy with pancreatic duct and biliary stent placement
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Qilu Hospital of Shandong University
Ampulla of Vater Adenoma
Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study
Endoscopic snare papillectomy (ESP) is an efficient treatment for benign tumors of the duodenal major papilla. But post-ESP pancreatitis is the most common and serious complication.
- Trial name
- PDS (NCT01737463)
- Testing
- Endoscopic snare papillectomy
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Soonchunhyang University Hospital
Ampullary Adenoma, Familial Adenomatous Polyposis
Endoscopic Papillectomy for Ampullary Adenomas
In this single-center experience we retrospectively evaluated principal clinical outcomes of endoscopic papillectomy in all patients referred to our unit.
- Trial name
- Papillectomy (NCT03494543)
- Testing
- Endoscopic Papillectomy
- Volunteers
- 62 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Adenoma, Villous
Long-term Outcomes of Endoscopic Resection (ER) of Lesions of the Duodenum and Ampulla
This research project, 'Outcomes of endoscopic resection of mucosal and submucosal lesions in the duodenum and ampulla'. The research project is aiming to determine the most effective and safe way to remove such lesions.
- Trial name
- OERDA (NCT02306603)
- Testing
- Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Professor Michael Bourke
Ampullary Adenoma, Chemotherapy Effect
Quantitative Nodal Burden as a Determinant Identifying Ampullary Adenocarcinoma Patients Benefiting From Adjuvant Chemotherapy
Ampullary cancer, a rare malignancy, lacks standardized guidelines for effective multimodal treatment following curative resection.
- Trial name
- NCT06435767
- Testing
- Adjuvant chemotherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences