Clinical trials: Amputation, open to volunteers
Unilateral Transfemoral Amputation
A Comparison Between Ischial-Containment and Sub-Ischial Prosthetic Sockets to Determine Their Effects on Secondary Health Conditions
Long-term above-knee prosthesis users are at an increased risk of developing secondary musculoskeletal conditions compared to the general able-bodied population.
- Trial name
- NCT07768072
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputation
A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
The hypothesis of this research protocol is that the investigators will be able to redesign the manner in which upper limb amputations are performed so as to enable volitional control of next generation prosthetic devices and…
- Trial name
- NCT03882073
- Testing
- Modified amputation procedure, Standard amputation procedure
- Where
- 4 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Amputation, Congenital, Upper Limb; Amelia
CNS Changes Following Upper Limb Loss
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss.
- Trial name
- NCT06043518
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Amputation
Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks
The purpose of this study is to evaluate the performance of a powered ankle prosthesis capable of bidirectional control via neural recording and cutaneous stimulation, during free-space and walking tasks.
- Trial name
- NCT07645729
- Testing
- Powered Prosthesis, Prescribed Prosthesis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Prosthesis User, Amputation
Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees
To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically relevant touch and/or movement feedback.
- Trial name
- NCT03135847
- Testing
- Tactor
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Amputation
Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs
The overall goal of this project is to model human joint biomechanics over continuously-varying locomotion to enable adaptive control of powered above-knee prostheses.
- Trial name
- NCT06138977
- Testing
- Powered prosthesis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Neuropathy, Neuropathy, Painful
MultiSENSory Stimulation to TArgeT Sensory Loss and ChronIc Pain in NeurOpathic PatieNts
Neuropathy is a costly and disabling health issue, which consists of a degeneration of the peripheral nerves. Even though the causes may be different, such as diabetes or amputation, the consequences for neuropathic patients are…
- Conditions
- Neuropathy, Neuropathy, Painful, Sensory Neuropathy, Diabetic Neuropathies
- Trial name
- SENSATION (NCT05483816)
- Testing
- VR+TENS
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Upper Limb Amputation, Healthy Subjects
Microneurography and Intraneural Microstimulation for Upper Limb Sensory Investigation in Healthy and Amputee Subjects
The goal of this experimental study is to investigate the somatosensory system through intraneural recording and stimulation of the median nerve in healthy volunteers and participants with upper-limb amputation.
- Trial name
- MICROAMP (NCT07691957)
- Testing
- Microneurography, Intraneural Microstimulation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Amputation, Functional Limitation
Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation
In France, more than 14 million individuals report severe functional limitations, and nearly 5 million struggle with essential daily activities.
- Conditions
- Amputation, Functional Limitation, Autonomy of Older People, Handicaps Physical
- Trial name
- BFB-IMPACT (NCT07314099)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondation Ildys
Lower Limb Amputation
Study of Locomotor Expectations for Ascending/Descending Slope and Stairs in Patients With Limb Amputations
Patients with lower limb amputations are equipped with prostheses that can be mechanical and/or electronic. These prostheses can be mono-articular (only the ankle) or bi-articular (knee and ankle for example).
- Trial name
- JCE (NCT04030650)
- Testing
- Functional analyses, 3D analysis of walking and balance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Transtibial Amputation, Transfemoral Amputation
Improving Socket Fit in Female and Male Veterans With Transtibial and Transfemoral Amputation
The investigators do not yet know how a prosthetic socket with adjustable panels affects the performance of people with a lower limb amputation compared to a conventional prosthetic socket.
- Trial name
- SocketFit (NCT05989243)
- Testing
- Conventional prosthetic socket, Adjustable Quatro socket
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Somatosensory Disorders, Amputation
Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses
Our sense of touch is essential to explore our environment and experience life and is based on signals from receptors in the body that are sensitive to different types of stimulation.
- Conditions
- Somatosensory Disorders, Amputation, Tactile Disorders, Aging
- Trial name
- TACTHUM (NCT05548322)
- Testing
- Different surfaces to be touched, Emotional state change, Electrical stimulation
- Where
- 2 sites in France
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Wounds and Injuries
Feasibility Study for Fibroblast Autologous Skin Grafts
This research is being done to determine if investigators can change skin from one type to another. Specifically, investigators are interested in making normal skin into the thicker skin found on our palms and soles.
- Trial name
- NCT01964859
- Testing
- autologous skin fibroblasts, Filler Product
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Pain
Unilateral Spinal Anesthesia vs Popliteal-Adductor Canal Block for Below-knee Amputation
To compare the mean duration of postoperative analgesia between unilateral spinal anaesthesia and combined popliteal sciatic nerve block with adductor canal block in diabetic patients undergoing below-knee amputation.
- Trial name
- NCT07854158
- Testing
- 0.5 % hyperbaric Bupvicaine, 15 ml of 0.5 bupvicaine
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Sargodha Medical College
Amputation, Surgical
Improving Prosthetic Arms for Amputee: A Better Fit and More Functionality
This research and development will improve upon and investigate the potential validity of an innovative new transradial socket and harness design (the KSH system) that offers an alternative to standard hard sockets and rubber…
- Trial name
- KSH (NCT05990062)
- Testing
- K-Socket-Harness
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputation
Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA
The proposal aims to investigate a non-invasive, cost-effective method for rebuilding muscle mass in individuals with transtibial limb loss.
- Trial name
- NCT06830876
- Testing
- Chattanooga Continuum Device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sara Peterson-Snyder
Lower-Limb Amputation
Motorized Prostheses for Lower-limb Amputees
The investigators will assess biomechanical and functional mobility outcomes in individuals with unilateral, above-knee amputations using different knee/ankle configurations of a lightweight powered prosthesis and different…
- Trial name
- NCT07486063
- Testing
- Powered and passive lower limb prosthesis and control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Wheelchair Users, Caregivers
New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)
The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness…
- Conditions
- Wheelchair Users, Caregivers, Wheelchair Service Providers, Amputation
- Trial name
- RAD-SI (NCT06831240)
- Testing
- Local wheelchair service provider questionnaires, Global wheelchair service provider questionnaires, End-users questionnaires
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Neuroma
Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation
This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using…
- Trial name
- NCT05008185
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) surgery, Traction Neurectomy
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute