Clinical trials: Amputation of Lower Limb Below Knee, active
Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Caesar Foot Take-Home Validation Testing
The rationale for this study is to conduct a take-home clinical trial to evaluate the impact of the bimodal Caesar foot in a real-world environment.
- Trial name
- NCT07075198
- Testing
- Caesar Foot
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Liberating Technologies, Inc.
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Phantom Limb Pain, Phantom Pain
VR to Evaluate Phantom Limb Pain
The objective of this study is to develop a virtual rehabilitation system that can be used to effectively treat Phantom Limb Pain (PLP) within the research setting and for at-home use by individuals with upper and lower extremity…
- Conditions
- Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain
- Trial name
- NCT05915065
- Testing
- Coapt Phantom Limb Pain Management System
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Study on a Prosthetic Foot With Adjustable Heel Height
Most prosthetic feet have a fixed heel height, which requires users to always wear shoes with the same heel height. A fixed heel height is a significant constraint, whereas the ability to choose one's clothing freely is an…
- Trial name
- ADJUST (NCT07214493)
- Testing
- Taleo Adjust, The usual participant's foot
- Where
- 5 sites in France
- Volunteers
- 30 people
- Sponsor
- Otto Bock France SNC
Amputation, Lower Limb Amputation Below Knee (Injury)
Prosthetic Performance Enhancement Trial
The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users.
- Conditions
- Amputation, Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation at Ankle (Injury)
- Trial name
- PROSPER (NCT06419920)
- Testing
- Flat terrain locomotor training, Uneven terrain locomotor training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nevada, Las Vegas
Stroke, Parkinson Disease
C-STAR Movement Database
The purpose of this study is to develop a database that contains movement and rehabilitation-related data collected through the use of wearable sensors and video.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
- Trial name
- NCT05471375
- Testing
- Database Entry
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Shirley Ryan AbilityLab
Lower Limb Amputation Below Knee
Automatic Prosthetic Foot Stiffness Modulation to Improve Balance in the Real World
The goal of this clinical trial is to determine if automatic stiffness modulation improves balance control in ambulatory individuals with below-knee amputations in real-world conditions.
- Trial name
- NCT07791433
- Testing
- Fixed stiffness prosthesis, Automatic stiffness prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Lower Limb Amputation Below Knee (Injury)
R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment
Lower limb amputees (LLA) rely on their prosthetic legs to remain active and lead an independent life. For most LLAs, a well-fitted prosthetic socket is the only option to interface with their prosthetic leg, however, it is a…
- Trial name
- ENABLE (NCT05425810)
- Testing
- Apply ENABLE sensing pad, Insert small pads at pressure tolerant locations
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- North Carolina State University
Lower Extremity Amputation
Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance
When the prosthetic socket of a Veteran with a lower limb amputation no longer fits or is damaged beyond repair, a new prosthetic socket is warranted.
- Trial name
- NCT05884203
- Testing
- Caregiver socket, Prosthetist socket
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception
The aim of the study is to evaluate the changes induced by a course of Transcutaneous Electrical Nerve Stimulation (TENS) treatment on the perception of phantom limb pain.
- Trial name
- SENSE-P (NCT07448350)
- Testing
- Transcutaneal Electrical Nerve Stimulation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Campus Bio-Medico University
Lower Limb Amputation Below Knee (Injury)
Restoration of Normative Postural Control
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1.
- Trial name
- NCT06452186
- Testing
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Carolina State University
Lower Limb Amputation Above Knee, Below Knee Amputation
Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation
The goal of this clinical trial is to learn if ischemic conditioning and neuromuscular electrical stimulation improves muscle strength and walking behavior in those with limb loss.
- Trial name
- NCT07664995
- Testing
- Blood pressure cuff, Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Illinois Chicago
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Lower Extremity Amputation
Adjustable Prosthetic Sockets for Individuals With Lower Limb Amputation
Each year, around 1500 Veterans join the 623,000 Americans who live with a lower limb amputation. Many of these Veterans choose the arduous path of rehabilitation to remain ambulatory, a process that includes the prescription of…
- Trial name
- NCT07397169
- Testing
- Adjustable prosthetic socket
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Office of Research and Development
Lower Limb Amputation Below Knee (Injury), Diurnal Residual Limb Fluid Volume Fluctuation
An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation
People with leg amputations often experience daily changes in the size (volume) of their residual limb. These daily changes can cause a prosthesis to fit poorly. They can also cause limb problems like pain or skin breakdown.
- Trial name
- NCT05124652
- Testing
- Auto Adjusting Prosthesis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Transtibial Amputation, Lower Limb Amputation Below Knee
Clinical Evaluation of the Access Socket Flexible Socket for Transtibial Prosthesis
Transtibial amputation significantly impacts patient autonomy and quality of life, primarily due to the limitations of conventional rigid sockets, which restrict comfort and joint range of motion.
- Trial name
- AS-TT (NCT07592325)
- Testing
- Access Socket (AS), Rigid Socket (RS)
- Where
- 5 sites in France
- Volunteers
- 25 people
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est