Clinical trials: Amputations
Lower Limb Amputation
Uses of Phantom Sensations Induced by Global and Local Modifications of the Prosthetic Socket as Somatosensory Feedback During Walking in Lower Limb Amputees
Following lower-limb amputation, the loss of somatosensory information from the missing limb renders walking less automatic, more cognitively demanding, and often asymmetric, which can lead to secondary pathologies.
- Trial name
- PhantomWalk (NCT07191795)
- Testing
- Gait analysis, Mapping of referred sensations., Exploration of the areas of the brain activated during referred sensations
- Where
- France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Lower Limb Amputation
Walking Strategies in Usual Locomotion of Lower Limb Amputees
Amputation is a life-altering event with an immediate and obvious effect on daily life activities and quality of life. Asymmetrical movements of the lower limbs and compensatory strategies during walking are associated with an…
- Trial name
- STRAAL (NCT05420623)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- FondationbHopale
Amputation
A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
The hypothesis of this research protocol is that the investigators will be able to redesign the manner in which upper limb amputations are performed so as to enable volitional control of next generation prosthetic devices and…
- Trial name
- NCT03882073
- Testing
- Modified amputation procedure, Standard amputation procedure
- Where
- 4 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gait, Balance
Gait Stability of People With Lower-limb Amputations
The purpose of this study is to evaluate whether there are quantifiable differences in walking stability, as measured by the acceleration of the trunk or the variation in step length, between people with unilateral below-knee…
- Trial name
- NCT00915109
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kim Parker
Lower Limb Amputation, Slip Perturbations
Pilot Study on the Evaluation of the Functionality, Safety and Reliability of New Tripping Devices for Lower Limbs.
The study aims to identify prognostic biomarkers of fall risk in patients with lower limb amputation
- Conditions
- Lower Limb Amputation, Slip Perturbations, Fall Risk
- Trial name
- MOTU++ pedane (NCT06883942)
- Testing
- prosthetic group performs the entire protocol with their own prosthesis, Experimental Group
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Amputation
Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees
This study will examine whether tactile (touch) abilities at the lip are more acute in people with upper limb amputation compared with healthy normal volunteers.
- Trial name
- NCT00028210
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Endodontic Inflammation, Pulp Disease, Dental
Evaluation of Clinical and Radiological Success of Vital Amputation Treatment
Total amputation therapy; is a treatment method aimed at maintaining the vitality of the radicular pulp remaining as a result of complete removal of coronal pulp tissue.
- Trial name
- NCT03883295
- Testing
- Control, NeoMTA Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Amputation
Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs
The overall goal of this project is to model human joint biomechanics over continuously-varying locomotion to enable adaptive control of powered above-knee prostheses.
- Trial name
- NCT06138977
- Testing
- Powered prosthesis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Amputation, Skin Wound
Autologous Volar Fibroblast Injection Into the Stump Site of Amputees
This study is a clinical trial testing the safety and efficacy of volar fibroblast (skin cells from the palm or sole) injections for thickening the epidermal (skin) layer at the stump site in people with below the knee…
- Conditions
- Amputation, Skin Wound, Stem Cell
- Trial name
- NCT03947450
- Testing
- Autologous Skin Fibroblasts
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Amputation, Amputation; Traumatic, Hand
Dexterous Partial Hand Prosthesis Outcomes
Liberating Technologies, Inc. (LTI) has developed a dexterous prosthetic fingertip that will be fit onto an i-Digits™ partial hand prosthesis and allow for an additional fine grasp.
- Conditions
- Amputation, Amputation; Traumatic, Hand, Limb; Absence, Congenital, Upper, Prosthesis User
- Trial name
- NCT05038566
- Testing
- Pointdexter
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Amputation Stump
Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets
The overall goal of this study is to further develop and clinically assess a computational and data-driven design and manufacturing framework for mechanical interfaces that quantitatively produces transtibial prosthetic sockets…
- Trial name
- NCT03544853
- Testing
- Prosthetic socket for transtibial amputee
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Neuropathic Pain, Amputation, Traumatic
Reiki for the Management of Neuropathic Pain
This is a prospective, randomized, double-blind, placebo-controlled, repeated measures study with intention-to-treat that involves exposure to Reiki therapy or a placebo control intervention for a total of six treatments, three…
- Trial name
- Reiki4Pain (NCT02328703)
- Testing
- Reiki Therapy
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Fort Belvoir Community Hospital
Blindness, Cerebrovascular Accident
Mechanisms of Human Plasticity in the Human System
The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain…
- Conditions
- Blindness, Cerebrovascular Accident, Spinal Cord Injury
- Trial name
- NCT00001661
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amputation
Targeted Muscle Reinnervation Study (TMR)
The purpose of this study is to examine the effect of targeted muscle reinnervation on the outcomes of amputees at a level 1 trauma center.
- Trial name
- TMR (NCT05408520)
- Testing
- Targeted Muscle Reinnervation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Low Back Pain
The Impact of Unilateral Lower Limb Amputation on Spinal Loads
The prevalence of low back pain among persons with unilateral lower limb amputation is significantly higher than the rate experienced by the general public.
- Trial name
- NCT02897973
- Testing
- Activity of daily living
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Amputation Stumps
A Comparative Analysis Between College Park Sidekick Feet and Conventional Stubby Prosthesis
The purpose of this study is to compare the College Park Sidekicks to conventional stubby prosthetics to investigate their effects on bilateral above-knee-amputee gait velocity, exertion, and balance.
- Trial name
- NCT02921295
- Testing
- Sidekick Stubbies
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Angela DeCandia
Virtual Reality
Effects of Virtual Reality on Transtibial Amputation Physiotherapy Outcomes
The aim of this study is to compare the effects of virtual reality applications on quality of life, performance, balance, prosthesis adaptation and gait parameters in individuals with transtibial amputation.
- Trial name
- NCT03872193
- Testing
- Exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation, Traumatic Amputation of Lower Extremity
Sitting Balance in Lower Limb Amputees
The aim of this study is to compare the sitting and standing postural stability of transfemoral individuals with healthy individuals with similar demographic characteristics.
- Trial name
- NCT05597696
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation, Traumatic, Traumatic Amputation of Lower Extremity
What is the Optimal Stiffness and Height of a Running-specific Prosthesis?
The proposed study aims to characterize the effects of running-specific leg prosthetic stiffness and height during on performance during running and sprinting to optimize running-specific prosthesis prescription.
- Conditions
- Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
- Trial name
- NCT02318979
- Testing
- Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Amputation
Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA
The proposal aims to investigate a non-invasive, cost-effective method for rebuilding muscle mass in individuals with transtibial limb loss.
- Trial name
- NCT06830876
- Testing
- Chattanooga Continuum Device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sara Peterson-Snyder