Clinical trials: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis, Alzheimer Disease
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
This is an open-label, biomarker-driven basket trial of baricitinib in people with subjective cognitive disorder, mild cognitive impairment, Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), or asymptomatic carriers…
- Conditions
- Amyotrophic Lateral Sclerosis, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NADALS (NCT05189106)
- Testing
- Baricitinib
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Amyotrophic Lateral Sclerosis
Rapamycin Treatment for ALS
In the last years research has pointed out potential mechanisms of pathogenesis in ALS including lack of degradation of abnormally accumulated proteins inside motor neurons, and an unbalanced function of the immune system leading…
- Trial name
- RAP-ALS (NCT03359538)
- Testing
- Rapamycin
- Where
- 7 sites in Italy
- Volunteers
- 63 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Amyotrophic Lateral Sclerosis
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to assess the effect of reldesemtiv versus placebo on functional outcomes in ALS.
- Trial name
- COURAGE-ALS (NCT04944784)
- Testing
- Reldesemtiv
- Where
- 84 sites in United States, Australia and 14 more
- Volunteers
- 489 people
- Sponsor
- Cytokinetics
Amyotrophic Lateral Sclerosis
Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis
This study is a single-center, randomized, double-blind, placebo parallel-controlled, dose-escalation clinical study. The aim of this study was to evaluate the safety, tolerability, and preliminary effect of Aleeto in adult…
- Trial name
- SPECIALS (NCT06181526)
- Testing
- Aleeto, intravenous injection, intrathecal injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis
A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS
Ambroxol is a simple cough medicine that is predicted to slow ALS disease progression. This study aims to investigate if ambroxol in high doses is effective in treating ALS.
- Trial name
- AMBALS (NCT05959850)
- Testing
- Ambroxol
- Where
- 5 sites in Australia
- Volunteers
- 50 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Amyotrophic Lateral Sclerosis
Modeling Amyotrophic Lateral Sclerosis With Fibroblasts
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults. This longitudinal study involves three cohorts of participants: patients with sporadic or hereditary ALS, asymptomatic individuals carrying…
- Trial name
- FIBRALS (NCT06450691)
- Testing
- biopsy
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia
Phenotype, Genotype and Biomarkers 2
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- PGB2 (NCT04875416)
- Where
- 4 sites in United States, South Africa
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Miami
Amyotrophic Lateral Sclerosis, Caregiver Burden
A Mindful Community for People With ALS and Their Primary Caregivers
The psychological impact of ALS on patients and caregivers is high, significantly affecting their quality of life (QOL). Despite this impact, there is not much research about psychological interventions that could reduce…
- Trial name
- NCT05595850
- Testing
- Mindfulness, Mindful Learning
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harvard University
ALS
Genomic Translation for Amyotrophic Lateral Sclerosis Care
The purpose of this study is to look for abnormal genes and gene expression profiles that help determine why a person develops amyotrophic lateral sclerosis (ALS) and related motor neuron diseases (MND) and why their symptoms…
- Trial name
- GTAC (NCT02795897)
- Where
- 14 sites in United States, United Kingdom
- Volunteers
- 254 people
- Sponsor
- Columbia University
Amyotrophic Lateral Sclerosis, Parkinson Disease
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for…
- Trial name
- NCT03613038
- Testing
- Phonetic complexity effects on speech motor performance
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Amyotrophic Lateral Sclerosis
A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis
This study will examine what happens when patients with amyotrophic lateral sclerosis (ALS) are given an investigational medication (study drug) known as LTX-002.
- Trial name
- NeurALS (NCT07660614)
- Testing
- LTX-002
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 56 people
- Sponsor
- Leal Therapeutics, Inc
Amyotrophic Lateral Sclerosis
Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosis
To evaluate the safety and effectiveness of intravenous infusion of plasma from healthy young people for the treatment of amyotrophic lateral sclerosis.
- Trial name
- NCT04454840
- Testing
- Plasma from healthy young people treatment + Riluzole, Riluzole
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
The primary objective is to demonstrate, in a population of chronic neuromuscular disease the non-inferiority of a rehabilitation treatment integrated with robotic and/or technological devices compared to traditional…
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease
- Trial name
- Fit4MR-ChrMND (NCT06881979)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Amyotrophic Lateral Sclerosis
Multidisciplinary Follow-up of Patients With Amyotrophic Lateral Sclerosis
Analyse a multidisciplinary follow-up of amyotrophic lateral sclerosis patients, monitored through a Cohort study at Geneva University Hospitals.
- Trial name
- NCT03536962
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Ruxandra Iancu Ferfoglia
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis
The purpose of this study is to find out if supervised exercise training using a treadmill with partial weight support is safe and has an impact on gait and function of persons with Amyotrophic lateral sclerosis.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Lou Gehrig's Disease
- Trial name
- NCT00956488
- Testing
- Treadmill Exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Amyotrophic Lateral Sclerosis
Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients
Amyotrophic lateral sclerosis (ALS) is a disease of an inflammatory nature, which causes progressive muscle weakness associated with cognitive and behavioural disorders.
- Trial name
- NCT04654689
- Testing
- Liposomed polyphenols resveratrol and curcumin, Isocaloric Diet, G04CB02
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Amyotrophic Lateral Sclerosis
Safety and Tolerability of Antiretroviral (Triumeq) in Patients With Amyotrophic Lateral Sclerosis (ALS).
This is a phase 2a open label, multicentre design study to investigate the safety of Triumeq in patients with ALS at 24 weeks post treatment.
- Trial name
- Lighthouse (NCT02868580)
- Testing
- Triumeq
- Where
- 4 sites in Australia
- Volunteers
- 43 people
- Sponsor
- Neuroscience Trials Australia
ALS
A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS)
The causes of ALS are largely unknown. However, mitochondrial dysfunction, resulting in impaired energy production, oxidative stress and apoptosis, may play a key role in ALS progression.
- Trial name
- NCT03506425
- Testing
- Triheptanoin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Richard Bedlack, M.D., Ph.D.