Clinical trials: Anabolic Resistance
Muscle Protein Synthesis
Anabolic Properties of Canola
Muscle tissue consists of proteins. These proteins are built up of small building blocks: amino acids. By consuming enough protein in our diet, we make sure that the body is provided with enough amino acids to facilitate muscle…
- Trial name
- ALPACA (NCT05664269)
- Testing
- drink ingestion, resistance-type exercise
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dietary Protein, Female Protein Metabolism
A 'Non-Invasive' Breath Test to Determine Anabolic Sensitivity in Females
The maintenance of lean body mass, especially skeletal muscle, is vital for optimal health and performance across the lifespan. The protein component of lean body mass is in a constant state of turnover, involving the…
- Conditions
- Dietary Protein, Female Protein Metabolism, Anabolic Sensitivity, Resistance Exercise
- Trial name
- FBT (NCT05422300)
- Testing
- Fed, Ex-Fed
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Aging, Age-Related Sarcopenia
Does Human Skeletal Muscle Possess an Epigenetic Memory of Testosterone?
This project's primary aim of this double-blinded, randomised, placebo-controlled trial is to investigate whether short-term testosterone administration +/- resistance exercise training induces a muscle memory response that can…
- Conditions
- Healthy Aging, Age-Related Sarcopenia, Testosterone Deficiency
- Trial name
- NCT05964920
- Testing
- Saline, Testosterone Undecanoate, Saline + Resistance exercise training
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Interventional
In Vivo and in Vitro Anabolic Potential of Essential Amino Acids Following Resistance Exercise
This study seeks to investigate the anabolic potential of a dileucine-enriched essential amino acid (EAA) formulation compared with a branched chain amino acid (BCAA) alternative and a collagen beverage on muscle protein…
- Trial name
- DiEx (NCT05754125)
- Testing
- Di-Leucine Supplement, BCAA Supplement, Collagen Supplement
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Aging
Mechanisms of Anabolic Resistance in Older Humans
The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.
- Trial name
- NCT06617195
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Resistance Exercise, Physical Inactivity
Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States
Developing tools to detect when our bodies are more resistant towards protein synthesis is valuable for identification of when someone may be at risk of losing body or muscle mass such as with aging or certain diseases.
- Conditions
- Resistance Exercise, Physical Inactivity, Amino Acids, Dietary Protein
- Trial name
- BTLP (NCT06209424)
- Testing
- Habitual Activity, Step-Reduction, Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Hypertrophy, Healthy and Well-Trained Men and Women
Time-Restricted Eating and Muscle Hypertrophy
The purpose is to examine the effects of time-restricted eating (TRE; consuming all calories within an 8-hour period each day) vs.
- Trial name
- NCT04000750
- Testing
- Time Restricted Eating, Normal Feeding, Resistance Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California State University, Fullerton
Regional Blood Flow
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance in Older People
With age, muscles tend to waste at 0.5-1% per year, so that an 80 year old may have only 70% of the muscle possessed at 50. Muscle loss makes it harder to carry out tasks that require strength, keep the body balanced and continue…
- Trial name
- Dunhill01 (NCT01734616)
- Testing
- Old Exercise, Old Acute Cocoa, Old 7 Day Cocoa
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men
Rationale: Age related muscle loss (sarcopenia) is assumed to be related to the impaired postprandial muscle protein synthetic response to protein and/or amino acid administration in the elderly vs the young.
- Trial name
- PRO-CARB (NCT01576848)
- Testing
- Protein, Protein + carbohydrate
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Supplement
Multi-ingredient Supplement for Strength and Power
It has been suggested that high amounts of total serum testosterone levels correlate with higher lean body mass, lowered fat mass, greater muscle strength, and faster recovery.
- Trial name
- NCT01971723
- Testing
- T+ Supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy
Forearm Immobilization, Metabolic Health, and Nutrition
The present study will investigate the impact of dietary branched chain amino acid restriction on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization
- Trial name
- NCT04626401
- Testing
- Forearm immobilization
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Skeletal Muscle Physiology
Muscle Memory After Treatment With Anabolic Substance Clenbuterol and Resistance Training in Humans
The purpose of the project is investigate muscle memory and underlying mechanisms in humans following resistance training and use of the anabolic substance clenbuterol.
- Trial name
- NCT05692856
- Testing
- Clenbuterol
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Sarcopenia
Lysosomal Movement and Anabolic Resistance
Age-associated loss of muscle mass, termed sarcopenia, is strongly associated with functional impairment and physical disability in the elderly.
- Trial name
- NCT03032757
- Testing
- Essential amino acids
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
- Trial name
- ARTIST-2 (NCT05261984)
- Testing
- Resistance exercise, Oral protein supplementation
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital