Clinical trials: Anaesthesia, active
Parturients, Accidental Puncture of Dura During Anaesthesia
Epidural Hydroxyethyl Starch for Post-Dural Puncture Headache in Parturients
The incidence of accidental dural puncture (ADP) among parturients receiving neuraxial labor analgesia has been reported to range from 1% to 1.5%.
- Conditions
- Parturients, Accidental Puncture of Dura During Anaesthesia, Epidural Filling, Hydroxyethyl Starch
- Trial name
- NCT07914790
- Testing
- Epidural hydroxyethyl starch, No epidural hydroxyethyl starch
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Peking University First Hospital
Spinal Anaesthesia Induced Hypotension
Effect of Ondansetron on the Incidence of Spinal Anaesthesia-Induced Hypotension in Elderly Patients Undergoing Fracture Hip Surgery
This study aims to compare prophylactic intravenous ondansetron 4 mg versus placebo regarding the incidence of spinal anaesthesia-induced hypotension, defined as mean arterial pressure (MAP) fall >20% from baseline or systolic…
- Trial name
- NCT07914868
- Testing
- Ondansetron
- Where
- Egypt
- Volunteers
- 142 people
- Sponsor
- Assiut University
Emergency Abdominal Surgery, Opioid Sparing Anaesthesia
Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery.
- Trial name
- NCT07262242
- Testing
- Lidocaine (drug), Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Breast Cancer Surgery, Locoregional Anaesthesia
Feasibility of a Standardized Fascial Plane Block Protocol for Breast Cancer Surgery
The goal of this observational study is to evaluate the feasibility of a standardized locoregional anesthesia protocol for patients undergoing breast cancer surgery under procedural sedation or adjunctive hypnosis.
- Conditions
- Breast Cancer Surgery, Locoregional Anaesthesia, Hypnosis, Fascial Plane Block
- Trial name
- FASTBREAST2026 (NCT07877740)
- Testing
- Standardized locoregional anesthesia protocol for breast cancer surgery
- Where
- Switzerland
- Volunteers
- 65 people
- Sponsor
- Hôpital Fribourgeois
Cardiac Anaesthesia, Cardiopulmonary Bypass
Comparison of Milrinone and Epinephrine on TAPSE
Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures.
- Trial name
- Milrinone (NCT07144267)
- Testing
- Epinephrine, Milrinone Injection
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Mansoura University
General Anaesthesia During Pregnancy
Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy.
- Trial name
- PAE-IQ (NCT06633406)
- Testing
- Age-appropriate Wechsler Intelligence Test, Disruptive Behavior Disorders Rating Scale, Social Responsiveness Scale
- Where
- 3 sites in Belgium
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Shivering, Hypothermia
Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia
Shivering is a common and distressing complication occurring in 40% to 60% of women undergoing cesarean section under spinal anesthesia.
- Conditions
- Shivering, Hypothermia, Cesarean Section, Spinal Anaesthesia
- Trial name
- NCT07855536
- Testing
- Dexmedetomidine, Meperidine, Normal Saline 0.9%
- Volunteers
- 99 people
- Sponsor
- Assiut University
Extubation Failures, Extubation
Comparison of Acute Airway/Respiratory Complications and Intervention Requirements in Extubations Performed During On-Hours Versus Off-Hours
Perioperative airway/respiratory complications are a major driver of morbidity and mortality. While UK audits NAP4 and NAP7 extensively examined major critical events (e.g., cardiac arrest), prospective standardized data on…
- Conditions
- Extubation Failures, Extubation, Airway Complication of Anaesthesia
- Trial name
- NCT07752173
- Testing
- Extubation, Survey/Questionnaire Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 2,640 people
- Sponsor
- Kocaeli City Hospital
Ablation Techniques, RFA, Ablation Treatment
Efficacy and Safety of RFA vs MWA for Treatment of Large Benign Thyroid Nodules, RCT
We conduct a multi-institutional randomized control trial of RFA and MWA for the primary treatment of large, benign nodules. Adult patients >/=18 years of age who have a solitary thyroid nodule ≥20ml in volume who presents to 1)…
- Conditions
- Ablation Techniques, RFA, Ablation Treatment, Benign Thyroid Nodules, Local Anaesthesia
- Trial name
- NCT07804862
- Testing
- Radiofrequency ablation alone, Microwave ablation
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Anaesthesia Complication, Perioperative Adverse Events
MC1R Mutations Associated With Red Hair and Perioperative Anesthesia Complications
The study aims to investigate whether patients with Melanocortin-1 receptor (MC1R) mutations, associated with red hair, or having a red hair phenotype, have a higher incidence of anesthesia-related perioperative complications.
- Conditions
- Anaesthesia Complication, Perioperative Adverse Events, Red Hair, Melanocortin 1 Receptor
- Trial name
- MARPAC (NCT07815431)
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Uppsala University
Post Operative Analgesia, Regional Anaesthesia
Comparison Between Paravertebral and Erector Spinal Block Efficacy in Robotic Thoracic Surgeries
The overall goal of this work is to find the preferred continues catheter- based thoracic block for patients who undergoing major ROBOTIC assisted thoracic surgery (Lobectomy, multiple segmental resection and thoracotomy).
- Conditions
- Post Operative Analgesia, Regional Anaesthesia, Pain After Surgery, Opioid Consumption
- Trial name
- TPVB vs ESP (NCT07782073)
- Testing
- Paravertebral Nerve Block, ESP block group
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Soroka University Medical Center
Postoperative Sleep Quality, Postoperative Behaviour
Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)
Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record.
- Conditions
- Postoperative Sleep Quality, Postoperative Behaviour, Postoperative Recovery in Children, Postoperative Nausea and Vomiting (PONV)
- Trial name
- SCORPION (NCT07777276)
- Testing
- Dexamethasone (IV), Ondansetron iv
- Where
- 3 sites in Australia, Brazil
- Volunteers
- 500 people
- Sponsor
- Telethon Kids Institute
Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty
Continuous Interscalene Blocks and Rebound Pain
The primary objectives of this present study are to examine whether a continuous interscalene block of a total duration of 48 hours reduces the incidence of rebound pain comparatively to single-shot interscalene block, through…
- Conditions
- Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Interscalene Analgesia, Interscalene Blocks
- Trial name
- NCT07770165
- Testing
- Continuous interscalene nerve block, Interscalene Block
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- University of Calgary
Breast Cancer, Postoperative Pain
Single vs Multiple Injection Intertransverse Process Block in Breast Cancer Surgery
This randomized clinical trial aims to evaluate and compare the analgesic efficacy of single Intertransverse Process Block (ITP) and multiple Intertransverse Process Block (ITP) in patients undergoing Breast Cancer Surgery.
- Conditions
- Breast Cancer, Postoperative Pain, Mastectomy, Regional Anaesthesia
- Trial name
- NCT07763756
- Testing
- Multiple Level Intertransverse Process Block, Single Level Intertransverse Process Block
- Volunteers
- 60 people
- Sponsor
- Antalya City Hospital
Dental Anaesthesia, Dental Pain
Photobiomodulation and Tooth Analgesia
The purpose of this study is to test photobiomodulation (PBM) with a non-invasive light device for reducing discomfort during dental treatments in children.
- Conditions
- Dental Anaesthesia, Dental Pain, Dental Analgesia
- Trial name
- NCT06691269
- Testing
- Photobiomodulation, Topical Benzocaine, Local Anesthesia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Quality Improvement, Quality of Recovery From Anaesthesia
The Impact of Fasting Duration on Quality of Recovery After Cesarean Section
This study will evaluate the effect of fasting duration and elective c-section start time on the overall quality of recovery. Patients will be seen 24 hours after surgery to answer 11 questions on their overall recovery after…
- Conditions
- Quality Improvement, Quality of Recovery From Anaesthesia, Cesarean Section, Fasting ( 6H for Solid ; 2H for Clear Fluid )
- Trial name
- NCT06701929
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Jewish General Hospital
Spinal Anaesthesia, Obesity
An Ultrasound Guided Automated Spinal Landmark Identification System
Neuraxial ultrasonography has been shown a safe and effective technique to enhance the overall success rate of lumbar puncture and reduce the number of injection attempts.
- Trial name
- uSINE (NCT03687411)
- Testing
- Neuraxial ultrasonography
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- KK Women's and Children's Hospital
Acute Pain, Post Operative Analgesia
Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy
Postoperative pain management is crucial for patients undergoing mastectomy for breast cancer. Regional analgesia techniques, such as the Thoracic Paravertebral Block (TPVB), are commonly used to reduce pain and opioid…
- Conditions
- Acute Pain, Post Operative Analgesia, Post Operative Pain, Acute, Breast Cancer
- Trial name
- PECS-TPVB (NCT07738770)
- Testing
- Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB)
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Dharmais National Cancer Center Hospital
Cholelithiases, Laparoscopic Cholecystectomy
"Comparison of of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Modes in Laparoscopic Cholecystectomy"
This randomized controlled trial compares volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) in adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Cholelithiases, Laparoscopic Cholecystectomy, General Anaesthesia
- Trial name
- VCV VS PCV (NCT07709039)
- Testing
- Volume-Controlled Ventilation, Pressure Controlled Ventilation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mehreen Mirza
Post Spinal Anaesthesia Hypotension
This is a Study That Aims to Estimate the Effect of Maternal Body Mass Index on the Prophylactic Dose of Norepinephrine Infusion for Preventing Hypotension in Parturient After Spinal Anesthesia
This is a randomized, double-blinded controlled study that aims to estimate the effect of maternal body mass index on the prophylactic dose of norepinephrine infusion for preventing hypotension in parturient after spinal…
- Trial name
- NCT07706426
- Testing
- Nor-epinephrine, Normal Saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University