Clinical trials: Anaesthesia Induction
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Propofol Anesthesia
Safety during modern practice of anaesthesia is of great concern. Patients admitted daily for surgical procedures undergoing general anaesthesia for different types of operations are exposed to different risks, starting from the…
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Reversal of Neuromuscular Blockade
- Trial name
- NCT07044180
- Testing
- pipecuronium bromide, Rocuronium bromide
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Tamas Vegh, MD
Cardiac Surgery
Ketamine and Kidney Injury in Cardiac Surgery
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
- Trial name
- NCT05268562
- Testing
- Ketamine, Propofol
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
HELLP Syndrome
General Anesthesia Versus Spinal Anesthesia in Patients of HELLP Syndrome
Anesthesia for caesarian section in patients with HELLP syndrome is a challenge. Measures should be taken during caesarian delivery to guard against the maternal and fetal complications associated with HELLP syndrome.
- Trial name
- NCT03111446
- Testing
- Spinal Anesthesia, General Anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Thoracic Paravertebral Block, Anesthesia Induction
The Impact of Ultrasound-Guided Superficial and Deep Paravertebral Nerve Blocks at the Superior Costotransverse Ligament on Hemodynamics During the Induction Phase of Thoracoscopic Lung Lobectomy: A Multicenter, Double-Blind, Randomized Controlled Trial
This study aims to determine whether performing a paravertebral nerve block at the superficial surface of the superior costotransverse ligament (SCTL) (without needle penetration of the SCTL) is more effective in maintaining…
- Conditions
- Thoracic Paravertebral Block, Anesthesia Induction, Hypotension on Induction
- Trial name
- NCT06841822
- Testing
- SCTL superficial plane block, SCTL deep plane block group
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Anesthesia, Epidural, Hypotension
Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
The purpose of this pilot trial is to examine the feasibility and ease of use of monitoring by ClearSight in laboring and delivering patients with the intent to compare time-to-treatment of hypotension between conventionally…
- Trial name
- NCT05906368
- Testing
- ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Pre-Eclampsia, Fetal Growth Retardation
Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common and important disorders of pregnancy. Both disorders are associated with an impairment of uteroplacental blood flow (UPBF).
- Trial name
- NCT00197340
- Testing
- Epidural ropivacaine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Hypotension on Induction
Hypotension in Children With Down Syndrome With Anesthesia Induction
Children generally undergo induction of anesthesia by inhalation of sevoflurane. Children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane.
- Trial name
- NCT04603469
- Testing
- Non invasive blood pressure
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
General Anesthesia Induction for Elective Surgery
Carotid Artery Corrected Flow Time Measured by Ultrasonography as a Predictor of Hypotension After Induction of General Anesthesia
Hypotension often happens immediately after anesthetic induction. Particularly in 5-10 minutes after anesthetic induction it is reported to happen more frequently.
- Trial name
- NCT02891772
- Testing
- ultrasonographic measurement of corrected flow time(FTc) in carotid artery
- Where
- South Korea
- Sponsor
- Yonsei University
Geriatric Population, Spinal Anesthesia Induced Hypotension
HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS
The goal of this clinical trial is to find out whether height-based dosing of spinal anaesthesia provides better hemodynamic stability and anesthetic outcome than conventional fixed dosing in elderly patients undergoing lower…
- Conditions
- Geriatric Population, Spinal Anesthesia Induced Hypotension, Spinal Anesthesia in Elderly Patients
- Trial name
- NCT07363941
- Testing
- Group A : Spinal Anaesthetic Dose, Group B : Conventional Dose
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Anesthesia; Functional
Simultaneous Injection of Propofol and Rocuronium in Inducing General Anesthesia
This study is conducted to evaluate the efficacy of simultaneous injection of propofol and rocuronium in inducing general anesthesia.
- Trial name
- NCT03270696
- Testing
- administration of propofol and rocuronium
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Seoul National University Hospital
Electroacupuncture, Lung Injury, Ventilator Induced
Protective Effect of Electroacupuncture on Lung in Patients Undergoing General Anesthesia
Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
- Trial name
- NCT05019079
- Testing
- electroacupuncture
- Volunteers
- 72 people
- Sponsor
- Lingling Ding
Radiography, Interventional
Early Detection of Intra Operative Hypotension (IOH) During the Induction of General Anaesthesia
During general anaesthesia, intraoperative hypotension (IOH), defined as a mean arterial pressure (MAP) drop of more than 20%, is frequent with potential deleterious effects for patients.
- Trial name
- NCT03756935
- Testing
- All monitoring
- Volunteers
- 62 people
- Sponsor
- Hopital Lariboisière
Spine Surgery, Intraoperative Neurophysiological Monitoring
Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring
This randomized controlled trial will compare two strategies for rocuronium use during general anesthesia for spine surgery with intraoperative neurophysiological monitoring.
- Conditions
- Spine Surgery, Intraoperative Neurophysiological Monitoring, Neuromuscular Blockade
- Trial name
- ROC-IONM (NCT07627750)
- Testing
- Low-Dose Rocuronium Maintenance, Rocuronium
- Where
- Vietnam
- Volunteers
- 62 people
- Sponsor
- Bach Mai Hospital
Anesthesia, General, Neuromuscular Blockade
Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)
The present trial is set up to evaluate the efficacy and safety of 4.0 mg.kg-1 sugammadex in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00826176
- Testing
- Sugammadex
- Volunteers
- 164 people
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Shivering, Cesarean Delivery
Intravenous Dexmeditomidine for Prevention of Spinal Anesthesia Induced Shivering.
Intraoperative and post operative shivering is a common problem encountered in operating rooms and recovery suites. Shivering under spinal anesthesia has an incidence of 40-60%.
- Trial name
- NCT05342376
- Testing
- Dexmedetomidine Hydrochloride, Normal Saline
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Tonsillectomy
Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents
Pain and anxiety have a direct correlation. Patients who experience anxiety are more susceptible to feeling pain, and patients who experience pain are more likely to have a component of anxiety associated with their pain.
- Trial name
- NCT03239743
- Testing
- Virtual Reality, Midazolam
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Anesthesia
Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?
To compare between fentanyl group and ketamine lidocaine group for induction of anesthesia as regards hemodynamics and smooth intubation.
- Trial name
- NCT03806374
- Testing
- Ketamine, Propofol, Fentanyl
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
PENG Block
Effectiveness Of The Pericapsular Nerve Group (PENG) Block In Hip Surgery
The target population of hip surgery is usually the elderly patients with systemic comorbidity. Especially hip fractures are common in society and cause high morbidity and mortality for geriatric patients .
- Trial name
- NCT05997940
- Testing
- PENG block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Aydin Adnan Menderes University
Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like…
- Conditions
- Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
- Trial name
- GEM-GLP1RA (NCT07100691)
- Testing
- Metoclopramide
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- Mater Misericordiae University Hospital
Active Emergence From General Anesthesia
EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia
The aim of this study is to test the hypothesis that methylphenidate actively induces emergence from propofol and sevoflurane general anesthesia in healthy volunteers.
- Trial name
- NCT02429076
- Testing
- IV methylphenidate, Sevoflurane, Propofol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital