Clinical trials: Anaesthesia and Analgesia
Pain
Patient Controlled Epidural Analgesia Versus Continuous Epidural Infusion: Obstetrical and Neonatal Outcomes
The investigators intend to perform a large randomized trial using standardized obstetrical and anesthetic practice at a single institution to determine the effects of patient controlled epidural analgesia on obstetrical and…
- Trial name
- Epidural (NCT00810914)
- Testing
- bupivicaine epidural, bupivicaine epidural infusion patient epidural, bupivicaine
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- MemorialCare
Pain, Postoperative, Anesthesia, Local
Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
This study will investigate the effect of three types of wound infiltration on post Cesarean opioid analgesia consumption when used in conjunction with an opioid free postoperative analgesia pathway.
- Conditions
- Pain, Postoperative, Anesthesia, Local, Opioid Use
- Trial name
- NCT03545516
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Richmond University Medical Center
Anesthesia, Surgery
Association Between Clinical Effect of Morphine With PCA After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- PCA-Gene (NCT01233752)
- Testing
- morphine chlorhydrate
- Where
- 2 sites in Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Anesthesia
Chloroprocaine for Continuous Epidural Analgesia in Neonates and Infants
This a study to retrospectively review our experience with the use of chloroprocaine for postoperative epidural infusions in neonates and infants.
- Trial name
- NCT02207855
- Testing
- Chloroprocaine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Joseph D. Tobias
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Epidural Analgesia for Labour and Delivery
Cross-legged Versus Traditional Sitting Position for the Success of Epidural Analgesia During Labor
The success of an epidural analgesia catheter placement depends on the parturient position. A poor posture can increase the number of punctures, patient discomfort, and risk of complications.
- Trial name
- IP3 (NCT04754282)
- Testing
- Position of labouring women for epidural analgesia catheter placement : Traditional Sitting Position (TSP), Position of labouring women for epidural analgesia catheter placement : Cross-legged Sitting Position (CSP)
- Where
- France
- Volunteers
- 457 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pain, Anesthesia
Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia
This randomized, blinded, controlled clinical trial aims to evaluate the effectiveness of ultrasound-guided retrolaminar block in reducing postoperative opioid consumption in patients undergoing lumbar spine fusion surgery under…
- Conditions
- Acute Pain, Anesthesia, Lumbar Spine Disease
- Trial name
- RBLUF (NCT07291388)
- Testing
- retrolaminar block
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Quadratus Lumborum Block, Abdominoplasty
Efficiency of the Quadratus Lumborum Block for Post-operative Analgesia in Abdominoplasty Surgery
Abdominoplasty is a common surgical procedure in plastic surgery which causes postoperative pain and may delay patients' recovery.
- Conditions
- Quadratus Lumborum Block, Abdominoplasty, Analgesia, Locoregional Anesthesia
- Trial name
- QLB (NCT04670224)
- Testing
- QLB anesthesia, Intravenous anesthesia without QLB
- Where
- France
- Volunteers
- 286 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Pain
RISS Versus ESP Block in Laparoscopic Cholecystectomy
This prospective randomized controlled trial aims to compare the analgesic efficacy and effects on diaphragmatic function of bilateral erector spinae plane (ESP) block and bilateral rhomboid intercostal-subserratus plane (RISS)…
- Trial name
- RISS-ESP-LC (NCT07655323)
- Testing
- Erector Spinae Plane Block, Rhomboid Intercostal-Subserratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Anesthesia
Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations
Until today there is no standard-monitoring to specifically reflect the analgesic component of general anesthesia. Quality and safety of general anesthesia are of major clinical importance and can be improved by limiting the…
- Trial name
- AMUPS (NCT02429960)
- Testing
- Analgesia monitor (PhysioDoloris®), Analgesia monitor (SPI®), Analgesia monitor (AlgiScan®)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anesthesia, Regional Anesthesia
Laparoscopic Sleeve Gastrectomy Surgery and External Oblique Intercostal Block
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Morbid Obesity, Postoperative Pain
- Trial name
- NCT05822479
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Postoperative Pain After Cesarean Section, Postoperative Pain
Abdominal Ice Application After Cesarean Section
Cesarean section is one of the most commonly performed surgical procedures worldwide, and effective postoperative pain control is important for maternal recovery and patient comfort.
- Conditions
- Postoperative Pain After Cesarean Section, Postoperative Pain, Cesarean Section
- Trial name
- ICE-CS (NCT07626138)
- Testing
- Abdominal Ice Application, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Nigde Omer Halisdemir University
Regional Anesthesia
A Randomized Clinical Trial
Acute postoperative pain is a common problem faced by the patient after surgery, most frequently occurring in first 24 hours. Our primary objective was to assess pain score in first 24 hours in PECS block group undergoing…
- Trial name
- NCT03947463
- Testing
- PECS block
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Pain in Pediatric Dentistry, Dental Anxiety
Effectiveness of Digital Anesthesia Versus Conventional Techniques in Reducing Pain and Anxiety in Children
This multicenter randomized controlled clinical trial was conducted to evaluate the effectiveness of digital anesthesia using a computer-controlled intraosseous system (SleeperOne 5®) compared to traditional local anesthesia…
- Trial name
- DAPAED (NCT06992193)
- Testing
- Digital Anesthesia, Infiltration Anesthesia, Mandibular Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Ege University
Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma
Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia
The aim of the study is to test the effectiveness and safety of the use of lidocaine infusion in multimodal analgesic management.
- Conditions
- Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma, Surgery, Pain, Postoperative
- Trial name
- NCT04691726
- Testing
- lidocaine 10mg/ml, Metamizole, Morphine
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Łukasz Krzych
Pregnancy Related, Hypotension, Orthostatic
Evaluation of Changes of Venous Return After Spinal and Epidural Analgesia and Anesthesia by Ultrasound Guided Vena Cava Diameter Measurement
The investigators propose this study to test the hypotheses that inferior vena cava (IVC) diameter can predict hypotension after labor analgesia (epidural, combined spinal-epidural) and neuraxial anesthesia for cesarean section…
- Trial name
- NCT03555799
- Testing
- Inferior vena cava ultrasound
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Augusta University
Postoperative Pain, Regional Anesthesia Morbidity
Rhomboid Intercostal and Subserratus Plane Block
This clinical trial will be conducted at Tanta University Hospitals, General Surgery Hospitals on female patients undergoing radical mastectomy . All the patients will receive general anesthesia.
- Trial name
- NCT04085263
- Testing
- Control group, Rhomboid intercostal and subserratus plane block group
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Tanta University
Combined Spinal-epidural Anesthesia
Relationship Between ANI, Anxiety, and Pain in Conscious Hernia Patients Undergoing CSEA
Analgesia Nociception Index can be used to detect noxious stimulation during general anesthesia.The aim of this study is to observe ANI under combined spinal epidural anesthesia procedures in conscious hernia patients.
- Trial name
- NCT05053633
- Testing
- Combined spinal epidural anesthesia
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Chao Yang Hospital
Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia
qNOX Response to Nociceptive Motor Events During Procedural Sedation
The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures.
- Conditions
- Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia, Monitored Anesthesia Care
- Trial name
- MO-NOX (NCT07413848)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
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