Clinical trials: Anaesthesia and Analgesia
Anesthesia, Analgesia
The Impact of the Anaesthetic Technique Employed on the Quality of Recovery in Patients Undergoing Hysterectomy Surgery.
The objective of this study is to evaluate the results of different anesthesia methods (general anesthesia with epidural catheter application and spinal anesthesia with epidural catheter application) applied in elective…
- Conditions
- Anesthesia, Analgesia, Acute Pain
- Trial name
- NCT06461832
- Testing
- Group 1, Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Samsun University
Episiotomy Wound
Comparison Between Lidocaine Prilocaine Cream and Lidocaine Injection on Pain Control During Episiotomy.
The present study aims to compare the effects of lidocaine-prilocaine cream and lidocaine injection on the reduction of pain while doing and repairing episiotomy, controlling the pain in the post-partum period, and reduction the…
- Trial name
- NCT05891132
- Testing
- 10 ml of lidocaine 2%, lidocaine prilocaine cream 15gm
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity Postoperative Pain, Obesity Morbid Obesity Postoperative Pain
Comparison of Paragastric Nerve Block and Erector Spinae Plane Block on Postoperative Pain After Sleeve Gastrectomy
Background: Laparoscopic sleeve gastrectomy is one of the most commonly performed bariatric procedures for the treatment of obesity.
- Trial name
- PGB-ESP (NCT07811206)
- Testing
- Paragastric Nerve Block (PGNB), ESPB, Active Comparator
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Atlas University
Pain, Anesthesia
Intranasal Dexmedetomidine Sedation and Analgesia During Pediatric Emergency Room Procedures
The study objective is to determine if intranasal dexmedetomidine is a safe and effective sedative drug during small painful procedures in the pediatric emergency room.
- Trial name
- INDEXER (NCT03564093)
- Testing
- Intranasal Drug
- Where
- Finland
- Volunteers
- 112 people
- Sponsor
- University of Oulu
Anesthesia, Local, Analgesia
The Efficacy of Suprainguinal Fascia Iliaca Compartment Block for Analgesia After Elective Total Hip Replacement.
Total hip replacement surgery is one of the most common orthopedic interventions. Proper anaesthesia and adequate analgesia is one of the key interests of attending anaesthetist.
- Conditions
- Anesthesia, Local, Analgesia, Arthropathy of Hip
- Trial name
- NCT04690647
- Testing
- Opioid and non opioid postoperative analgesia., Fascia iliaca compartment block, Dexamethasone
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Saint Lucas Hospital, Poland
Analgesia, Pain
Postoperative Pain and SIRS After Preoperative Analgesia With Clonidine or Levobupivacaine
The purpose of this study was to investigate hypothesis that preoperative administration of epidural clonidine will reduce postoperative pain and systemic inflammatory stress response better than epidural levobupivacaine.
- Conditions
- Analgesia, Pain, Systemic Inflammatory Stress Response
- Trial name
- PPSAPACL (NCT00860899)
- Testing
- clonidine, levobupivacaine
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- University Hospital Dubrava
Pain, Postoperative Pain
REduced Pain After Bariatric Surgery - Sleeve Gastrectomy
This study aims to analyze the effect of laparoscopic guided transversus abdominis plane (LG-TAP) block compared to placebo for postoperative analgesia following laparoscopic sleeve gastrectomy.
- Conditions
- Pain, Postoperative Pain, Acute Pain, Analgesia
- Trial name
- REPABS-SG (NCT06383234)
- Testing
- LG-TAP block with local anesthetic, LG-TAP block with saline solution, Port site infiltration
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Anesthesia, Bariatric Surgery (Gastric Bypass)
Comparison of Intensive and Conservative NOL®-Guided Analgesia Strategies During Opioid-free Anesthesia
Participants will be randomized to one of two predefined NOL®-guided analgesia strategies during bariatric surgery performed under OFA.
- Trial name
- OFANOL (NCT07917299)
- Testing
- Study Intervention, Control Intervention
- Volunteers
- 400 people
- Sponsor
- Prof Urs Zingg
Laparoscopic Cholecystectomy
Kidney Function After Pneumoperitoneum and Analgesia
double blind study of kidney function of two groups of adult patients submitted to laparoscopic cholecystectomy and analgesia from tramadol associated to dipyrone or ketorolac
- Trial name
- NCT00914875
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Aortic Aneurysm, Postoperative Nausea and Vomiting
AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair
The aim of this randomized trial is to assess the efficacy of analgesia using either thoracic epidural or intravenous infusions for open lumbar infrarenal aortic aneurys repair and compare Numerical Rating Scale (NRS) with…
- Conditions
- Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain, Haemodynamic Stability
- Trial name
- AoA-AAA (NCT06609993)
- Testing
- intravenous rescue opioid analgesia using fentanyl, intravenous rescue atropine administration, intravenous rescue urapidil administration
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Michał Stasiowski
Postoperative Pain, General Anesthesia
ANI-Guided Anesthetic Desflurane Consumption
General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability.
- Conditions
- Postoperative Pain, General Anesthesia, Laparoscopic Cholecystectomy
- Trial name
- NCT06982209
- Testing
- Analgesia/Nociception Index (ANI)
- Where
- South Korea
- Volunteers
- 125 people
- Sponsor
- Wonkwang University Hospital
General Anesthetic Drug Overdose, Adverse Effect of Intravenous Anesthetics, Sequela
Fully Automated Anesthesia, Analgesia and Fluid Management
Evaluate the feasibility and quality of automated anesthesia, analgesia and fluid management based on a combination of several physiological variables (bispectral index [BIS], stroke volume [SV], and stroke volume variation…
- Conditions
- General Anesthetic Drug Overdose, Adverse Effect of Intravenous Anesthetics, Sequela, Complication of Anesthesia, Drug Delivery System Malfunction
- Trial name
- NCT02886806
- Testing
- BIS XP, Covidien, Ireland, EV-1000 TM, Edwards Lifesciences, Irvine, California, USA
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Erasme University Hospital
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Pregnancy, Cesarean Section
RCT of Epinephrine (None, 100mcg, and 200mcg) in a Hyperbaric Bupivacaine, Fentanyl and Morphine Spinal in C-sections.
This is a prospective, randomized, double blind study of 75 patients (n=25 for each group) in which epinephrine (100mcg or 200mcg) or normal saline vehicle is added to intrathecal hyperbaric bupivacaine (0.75% bupivacaine…
- Trial name
- NCT03335293
- Testing
- 100 mcg Epinephrine, normal saline, 200 mcg Epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Implanted Venous Access Device
Use of Virtual Reality Mask or Music Therapy for Analgesia and Anxiolytic Purpose When Totally IVAD for Chemotherapy Under Local Anesthesia
Evaluate 2 medical devices on pain average and/or anxiety average in the totally Implanted Venous Access Device (IVAD) procedure under local anesthesia.
- Trial name
- REVCCI (NCT04804735)
- Testing
- REV : local anesthesia and virtual reality, MUS : local anesthesia and music therapy
- Where
- 3 sites in France
- Volunteers
- 127 people
- Sponsor
- Institut Curie
Postoperative Pain, Laparoscopic Cholecystectomy
Optimal Patient Positioning for Erector Spinae Plane Block in Laparoscopic Cholecystectomy:
This randomized clinical study aims to compare the postoperative analgesic efficacy, analgesic consumption, and patient satisfaction of erector spinae plane (ESP) block administered in three different patient positions-lateral…
- Conditions
- Postoperative Pain, Laparoscopic Cholecystectomy, Anesthesia, Regional, Pain Management
- Trial name
- ESP-POSTURE (NCT07018258)
- Testing
- Erector Spinae Plane (ESP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Harran University
Elderly Patients, Solid Organ Cancer
Epidural Anesthesia and Long-term Outcomes in Elderly Patients After Surgery
Surgical resection is one of the most important treatments for solid organ cancer. Whereas cancer recurrence and/or metastasis are the major reasons of treatment failure.
- Conditions
- Elderly Patients, Solid Organ Cancer, Surgical Resection, Epidural Anesthesia
- Trial name
- NCT03335826
- Testing
- Combined epidural-general anesthesia, General anesthesia
- Where
- 5 sites in China
- Volunteers
- 1,802 people
- Sponsor
- Peking University First Hospital
Postoperative Pain
Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide…
- Trial name
- NCT07644923
- Testing
- Bupivacaine, Lidocaine, Thrombin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Postoperative Pain, Weakness, Muscle
Periarticular Infiltration of Local Anesthetics Versus Pericapsular Nerve Group Block for Total Hip Replacement
This randomized trial is set out to compare the postoperative strength preservation capacity of local infiltration anesthesia (LIA) and pericapsular nerve group (PENG) block after performing a primary total hip arthroplasty…
- Conditions
- Postoperative Pain, Weakness, Muscle, Analgesia, Motor Activity
- Trial name
- NCT05087862
- Testing
- Ultrasound-guided pericapsular nerves group of the hip block, Pericapsular local anesthetic infiltration of the hip
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
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