Clinical trials: Anaesthesia and Analgesia
Analgesia, Anesthesia
Comparing Skin Conductance and Nol-index
Comparison of twà different nociception monitors during general anesthesia
- Conditions
- Analgesia, Anesthesia, Monitoring, Vascular Diseases
- Trial name
- NCT04138966
- Testing
- Nol-Index, Skin Conductance
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Erasme University Hospital
Anesthesia, Sedation and Analgesia
Prospective IR-led Sedation Feasibility
This study wants to see if some interventional radiology (IR) procedures can be done without using general anesthesia. General anesthesia needs a lot of staff and equipment. It can also cause side effects.
- Conditions
- Anesthesia, Sedation and Analgesia, Interventional Radiology
- Trial name
- NCT07443254
- Testing
- ketamine, Fentanyl (IV), Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CAMC Health System
Anesthesia, Local, Analgesia
Analgesic Efficacy of Ultrasound Guided Bilateral Erector Spinae Plane Block in Pediatric.
This randomized, double-blinded, study aims to compare the efficacy of analgesia and any side effects of U/S guided bilateral Erector SpinaePlane block versus non-block t paediatric patients undergoing corrective cardiac…
- Trial name
- NCT04452656
- Testing
- bilateral erector spinae block
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Cairo University
Post-operative Surgical Pain
Regional Anesthesia (Supra-Orbital and Infra-Orbital Nerve Block) (SION) for Pain Management in Trans-sphenoidal Hypophysectomy
This is a prospective, randomized, blinded, sham controlled regional anesthetic (supra-orbital and infra-orbital nerve block) pain study to compare the systemic postoperative pain medication requirements in patients having…
- Trial name
- SION (NCT04670614)
- Testing
- Nerve Block with ropivicaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ovarian Neoplasm
Impact of Specific Monitoring of Intraoperative Analgesia Under General Anesthesia on Chronic Pain After Ovarian Cancer Surgery
This is a single-center, randomized, phase II, non-comparative, single-blind clinical study that will determine whether morphine reduction through intraoperative monitoring by ANI (Analgesia Nociception Index) significantly…
- Trial name
- MONIALC (NCT04906187)
- Testing
- Arm A : intraoperative ANI monitoring of nociception, Arm B : no specific monitoring of nociception
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Institut Bergonié
Gender Affirming Surgery, Mastectomy
Gender Affirming Mastectomy Analgesia Rial
Introduction: Optimizing pain management after gender-affirming mastectomy (removal of breast tissue, aka top surgery) surgery is important for recovery and minimizing opioid use.
- Conditions
- Gender Affirming Surgery, Mastectomy, Acute Pain
- Trial name
- GAMA (NCT07861165)
- Testing
- Paravertebral (single injection), Wide local infiltration
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Nova Scotia Health Authority
Hip Osteoarthritis, Total Hip Arthroplasty (THA)
QIPB vs SI-FICB for Postoperative Analgesia After Total Hip Arthroplasty
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer…
- Conditions
- Hip Osteoarthritis, Total Hip Arthroplasty (THA), Postoperative Pain, Acute Pain
- Trial name
- NCT07683663
- Testing
- Supra-Inguinal Fascia Iliaca Compartment Block, Quadro-Iliac Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dokuz Eylul University
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Anesthesia
Efficacy of Virtual Reality Distraction Technique for Anxiety and Pain Control in Orthopedic Forearm Surgeries Performed Under Supraclavicular Brachial Plexus Block
Invistigators hypothesized that using of VR distraction technique during performing peripheral regional anesthesia (supraclavicular block) would lead to better perioperative analgesia and less anxiety.
- Trial name
- NCT05512728
- Testing
- VR, Midazolam
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Regional Anesthesia Block, Anesthesia and Analgesia
Analgesic Comparison of Transversus Fascial Plane and Quadratus Lumborum Blocks in Pediatric Urogenital Procedures
This study aims to compare the analgesic effectiveness of the preoperatively administered Anterior Quadratus Lumborum Block (Anterior QLB) and the Transversalis Fascia Plane Block (TFP block) in children undergoing lower…
- Conditions
- Regional Anesthesia Block, Anesthesia and Analgesia, Pediatric Anesthesia, Pediatric Regional Anesthesia
- Trial name
- NCT07256899
- Testing
- Anterior Quadratus Lumborum Block (QLB), Transversalis Fascia Plane (TFP / TAP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Istanbul University - Cerrahpasa
Mastectomy, Postoperative Pain
Comparison of Postoperative Analgesic Effectiveness of Superficial and Deep Serratus Plane Blocks for Mastectomy
Pain after breast surgery can be quite severe and can significantly affect quality of life. By successfully treating acute pain, it is aimed to prevent the formation of pain memory and to ensure that chronic pain never occurs.
- Conditions
- Mastectomy, Postoperative Pain, Analgesia
- Trial name
- NCT06438211
- Testing
- superficial or deep serratus anterior plane block for mastectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- TC Erciyes University
Thoracic Diseases, Thoracic Surgery
Deep Serratus Anterior Plane Block vs Surgically-placed Paravertebral Block for VATS Surgery
Thoracic surgery, and surgery involving the chest wall in general, is associated with poorly controlled acute pain, which may result in delayed functional recovery, and may progress to chronic pain.
- Conditions
- Thoracic Diseases, Thoracic Surgery, Rib Fractures, Pain, Postoperative
- Trial name
- SAPB (NCT03768193)
- Testing
- Deep serratus anterior plane block, Surgically-placed paravertebral block
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mater Misericordiae University Hospital
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Regional Anaesthesia
QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery
Local and/or regional analgesia techniques are critical components of an optimal multimodal analgesia technique, as they have been shown to improve pain relief as well as reduce opioid requirements.
- Trial name
- NCT06688136
- Testing
- ropivacaine
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Huazhong University of Science and Technology
Analgesia, Cesarean
Inadequate Analgesia During Cesarean Section Under Spinal Anesthesia
Inadequate analgesia during cesarean section is a common condition, notably addressed by national recommendations from the SFAR (French Society of Anesthesia and Intensive Care) in 2021.
- Trial name
- ALGOCESA (NCT07312487)
- Where
- France
- Volunteers
- 2,450 people
- Sponsor
- University Hospital, Strasbourg, France
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury
General Anaesthesia
Evaluation of Analgesia Nociception Index (ANI) During Propofol/Remifentanil and Sevoflurane/Remifentanil Anesthesia
The aim of this prospective randomized study was to evaluate the ability of the new Analgesia Nociception Index ANI, derived by heart rate variability, to detect painful stimulation during either propofol or sevoflurane…
- Trial name
- NCT01522508
- Testing
- tetanic stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Head and Neck Cancer, Free Tissue Transfer
Local Infusion of Ropivacaine for Post-Op Pain Control After Osseocutaneous Free Flaps
Head and neck oncologic surgery often requires the use of free tissue transfer, or microvascular reconstruction, to reconstruct defects created by tumor resections.
- Trial name
- NCT03349034
- Testing
- Ropivicaine, Local Saline Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
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