Clinical trials: Anaesthesia and Analgesia
Shoulder Pain
Interscalene Block Versus Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder Surgery
This randomized controlled trial aims to compare the effectiveness of interscalene (ISB) and serratus posterior superior intercostal plane block (SPSIP) for postoperative analgesia in patients undergoing elective arthroscopic…
- Trial name
- NCT07311096
- Testing
- Interscalene Brachial Plexus Block (ISB), Serratus Posterior Superior Intercostal Plane Block (SPSIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erzurum Regional Training & Research Hospital
Postoperative Pain, Analgesics, Opioid
The Effects of TFPB on Opioid Consumption in Patients Undergoing HLDN
This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive…
- Conditions
- Postoperative Pain, Analgesics, Opioid, Pain Management, Anesthesia Regional
- Trial name
- NCT07396753
- Testing
- Ultrasound-guided transversalis fascia plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koç University
Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus
Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery
Regional anaesthesia is a commonly used and effective analgesic modality in orthopaedic surgery. The benefits of peripheral nerve blocks (PNB) include better pain relief, limited opioid consumption and high patient…
- Conditions
- Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus, Ankle Fracture - Medial Malleolus, Rebound Pain
- Trial name
- NCT06864312
- Testing
- continuous infusion of levobupivacaine, oxycodone
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- University College Cork
Pain, Postoperative
Cesarean Delivery and Post-operative Pain Management With Local Anesthesia
The use of .5% Bupivacaine with epinephrine at the time of skin closure in cesarean deliveries will decrease post-op pain.
- Trial name
- NCT00298571
- Testing
- .5% bupivacaine with epinephrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Elective Surgical Procedures, Postoperative Pain
Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair
Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and…
- Conditions
- Elective Surgical Procedures, Postoperative Pain, Anesthesia, Opioid Use
- Trial name
- NCT04894864
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Crete
Anesthesia, Local, Postoperative Pain
Comparison of Lateral and Medial Approaches to Costoclavicular Brachial Plexus Block in Pediatrics
In upper extremity surgeries, the brachial plexus block can be performed with different techniques at various levels depending on the proximal and distal level of the surgery.
- Trial name
- NCT04786756
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Effects of; Anesthesia, in Labor and Delivery, Pregnancy
Effects of Analgesic Techniques on Duration of Labor for Induction Patients
The purpose of this study is to determine if there is a difference in the duration of the first stage of labor in nulliparous women scheduled for an induction of labor, with whom analgesia is maintained with a combined spinal…
- Conditions
- Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
- Trial name
- NCT01982851
- Testing
- Epidural de novo, CSE
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Internal Derangement of Hip, Acetabular Labrum Tear
Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain
The goal of the study is to evaluate via a prospective, blinded, randomized clinical trial, whether ultrasound-guided single femoral and lateral femoral cutaneous nerve blocks with ropivacaine 0.5% with epinephrine (1:200,000) as…
- Trial name
- NCT01997567
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rush University Medical Center
Breast Cancer, Pain, Postoperative
Comparative Sensory Mapping of Regional Anesthesia Techniques in Breast Cancer Surgery
Various regional anesthesia techniques, either individually or in combination, can be utilized for analgesia in breast cancer surgery.
- Trial name
- NCT06911892
- Testing
- Group Serratus Anterior Plane Block, Group Parasternal Block, Group Interpectoral+Pectoserratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Samsun University
Anesthesia
Ultrasound-guided Interscalene Brachial Plexus Block: Single Bolus vs Continuous Catheter Placement in Arthroscopic Rotator Cuff Repair
Shoulder arthroscopy is a minimally invasive procedure frequently used for rotator cuff repair. Patients may experience severe postoperative (PO) pain, that can last for a month and can influence successful rehabilitation.
- Trial name
- ISB (NCT06855381)
- Testing
- the ISBC group, SonoPlex needle and E-catheter, single bolus injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Foggia
Intranasal Dexmedetomidine, Intranasal Bupivacaine
Intranasal Injection of Dexmedetomidine and Bupivacaine in Septoplasty Surgeries
Pain is particularly common after nasal surgery, especially when bone manipulation and periosteal irritation are involved. Appropriate pain control is an important consideration in the post-surgical management of patients.
- Conditions
- Intranasal Dexmedetomidine, Intranasal Bupivacaine, Septoplasty Surgeries
- Trial name
- NCT03926663
- Testing
- Dexmedetomidine, Bupivacaine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Anesthesia
Hypnoanalgesia for Dermatological Surgery in Children
This randomized clinical trial will evaluate the effect of hypnosedation on the need of sedation and analgesia in a pediatric population undergoing dermatological surgery, both during the procedure, and 24 hours after surgery.
- Trial name
- NCT04707014
- Testing
- Hypnosis, Attention-distracting techniques
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Complejo Hospitalario de Toledo
Abortion, Induced
Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen
To compare postoperative analgesia by paracetamol 1gr or ketoprofen 100 mg or the combination of these two analgesics each treatment beeing allocated by randomization
- Trial name
- NCT00188071
- Testing
- paracetamol, ketoprofen, ketoprofen + paracetamol
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Angers
Contraception, Pain, Acute
Empathy Through Pain Control: Buffered Compared to Unbuffered 1% Lidocaine During IUD Placement
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed.
- Conditions
- Contraception, Pain, Acute, Anesthesia, Local
- Trial name
- EPIC2 (NCT06974019)
- Testing
- Buffered Lidocaine, Lidocaine 1% Injectable Solution
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Elderly, Epidural Anesthesia
Anesthesia-analgesia Methods and Postoperative Delirium
Postoperative delirium is a common complication in elderly patients after surgery. Its occurrence is associated with worse outcomes. The pathophysiology of delirium remains poorly understood.
- Conditions
- Elderly, Epidural Anesthesia, General Anesthesia, Major Surgery
- Trial name
- NCT01661907
- Testing
- Combined Epi-GA/PCEA, GA/PCIA
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Peking University First Hospital
Digestive System Disease, Surgery
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia
The purpose of this study is to evaluate the superiority of IV lidocaine combined with morphine spinal anesthesia versus placebo combined with morphine spinal anesthesia, in reducing postoperative morphine consumption at 48…
- Trial name
- LIDORACHI (NCT07076641)
- Testing
- rachi morphine anesthesia, laparotomy, Lidocaine IV
- Where
- France
- Volunteers
- 76 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Analgesia
Efficacy and Safety of HSK21542 in Inducing Postoperative Analgesia in Undergoing Elective Laparoscopic Surgery
This is a multicenter, randomized, double-blind, placebo-controlled, two-stage phase II clinical study. The main objective is to evaluate the efficacy and safety of HSK21542 injection and explore the recommended dose and…
- Trial name
- NCT04424251
- Testing
- Experimental: stage I：HSK21542 0.4 μg/kg, Experimental: stage I：HSK21542 1 μg/kg, Experimental: stage I：HSK21542 0.5μg/kg
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Hip Replacement Surgery, Hip Replacement, Total
OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study
Main indications for total hip arthroplasty (THA) are degenerative osteoarthritis of the coxofemoral joint, osteonecrosis of the hip, congenital disorders such as dysplasia and inflammatory arthritis.
- Conditions
- Hip Replacement Surgery, Hip Replacement, Total, Hip Pain, Hip Arthroplasty
- Trial name
- NCT07017192
- Testing
- SIFI Block, ESP block
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Cesarean Section, Dexamethasone
Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia
The management of postpartum pain is essential to ensure early rehabilitation for parturients. Intravenous dexamethasone has a potent analgesic action when used in the context of general anesthesia.
- Conditions
- Cesarean Section, Dexamethasone, Postoperative Pain, Spinal Anesthesia
- Trial name
- NCT05535036
- Testing
- Dexamethasone 4mg
- Where
- Tunisia
- Volunteers
- 84 people
- Sponsor
- Mongi Slim Hospital
Orchiopexy
Comparison of Analgesic Efficacy of Fascia Transversalis Plan Block and Caudal Epidural Block in Pediatric Patients Undergoing Orchiopexy
Orchiopexy is a surgery with a high frequency in the pediatric population. The use of regional anesthesia techniques has become widespread and its importance has increased in order to provide more effective and prolonged…
- Trial name
- NCT07006844
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
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