Clinical trials: Anal Fistulas
Perianal Fistula, Transsphincteric Anal Fistula
Treatment of Lower Transsphincteric Perianal Fistula: Fistulotomy With Marsupialization vs Open Wound
This study will compare the results of marsupialization versus open wound after fistulotomy in low transsphincteric perianal fistulas.
- Trial name
- NCT04722965
- Testing
- Fistulotomy with marsupialization, Fistulotomy with open wound
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Anal Fistula
Treatment of Transsphicteric Fistula-in-ano by Method of Laser Thermoobliteration(FiLaC™).
This is a randomized, controlled, parallel study to compare the results of treatment for patients with transsphincteric fistulas-in-ano.
- Trial name
- NCT03690934
- Testing
- Fistula-tract laser closure (FiLAC™), Monopolar coagulation of fistulous tract
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Crohn Disease, Fistula
Anal Crohn Fistula Surgery
The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.
- Conditions
- Crohn Disease, Fistula, Anoperineal Fistula, Anal Fistula
- Trial name
- FACC (NCT01388257)
- Testing
- All types of surgery procedures, Simple seton drain removal
- Where
- 15 sites in France
- Volunteers
- 180 people
- Sponsor
- French Society of Coloproctology
Fistula Perianal
Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula
The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease.
- Trial name
- NCT06568653
- Testing
- exosome, routine conventional fistulotomy
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Anal Fistula, Complex Perianal Fistulas
Evaluate the Distribution and Dynamic Behavior of TH-SC01 Cells in Vivo in Patients With Perianal Fistula
The purpose of this study is to evaluate the distribution and dynamic behavior of Nuclide labeled TH-SC01 cells in vivo in patients with perianal fistula
- Conditions
- Anal Fistula, Complex Perianal Fistulas, Crohn's Disease
- Trial name
- NCT06429241
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Anal Fistula
E-CEL UVEC as an Adjunct Cell Therapy for Treatment of Anal Fistulas
The purpose of this study is to determine if endothelial cells derived from human umbilical vein are safe for use in conjunction with fistulotomy for the treatment of simple anal fistulas.
- Trial name
- NCT04190862
- Testing
- E-CEL UVEC
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Crohn Disease, Ano Fistula
Study of the 12-month Efficacy of Stem Cell Injection in Crohn's Disease With Complex Ano-perineal Fistula
Ano-perineal (or ano-rectal) fistulas are a frequent and major complication of Crohn's disease. Indeed, they indicate a greater severity of the disease. In addition, they have a major impact on the quality of life of patients.
- Trial name
- ECESMAC (NCT05177003)
- Where
- 2 sites in France
- Volunteers
- 27 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Anal Fistula
3D Endoanal Ultrasound and Anal Fistula
The study aims to evaluate the use of 3D endoanal ultrasound in preoperative management of anal fistula disease.
- Trial name
- UFU (NCT03937752)
- Testing
- 3D endodanal ultrasound
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
Anal Fistula Surgery, Anal Fistula
Impact of Surgical Timing on Anal Fistula Outcomes
This study aims to evaluate if the amount of time a person experiences symptoms of an anal fistula before having surgery affects their surgical outcomes and recovery.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Surgery Timing
- Trial name
- NCT07482241
- Volunteers
- 90 people
- Sponsor
- Assiut University
Anal Fistula
Fistulotomy With or Without Marsupialization for Treatment of Simple Anal Fistula
Patients with simple anal fistula will undergo fistulotomy operation and will be divided into two groups: the first will undergo marsupialization of the laid open fistula track and second group will not undergo marsupialization.
- Trial name
- NCT03595839
- Testing
- Fistulotomy, Marsupialization
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Anal Fistulas, Anal Fistula
Identifying Landmark Factors of Anal Fistulas
The goal of this observational study is to understand the effects of anatomical factors, etiology, and complexity of anal fistula on the prognosis of patients undergoing anal fistula surgery within one year post-operation.The…
- Trial name
- NCT06421129
- Testing
- anal fistula surgery
- Where
- China
- Volunteers
- 326 people
- Sponsor
- Guanlin Liu
Hemorrhoid, Peri Anal Fistula
Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
In this prospective randomized study the investigators aimed to investigate difference of the duration of spinal anesthesia, discharge times and efficacy between low dose heavy Prilocaine-Fentanyl and heavy Bupivacaine-Fentanyl…
- Trial name
- NCT01880775
- Testing
- Prilocaine, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Crohn Disease
An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF
Crohn's disease is a chronic inflammation of all or part of the digestive tract, " from the mouth to the anus ". . Cell therapy is a new and promising approach for the treatment of inflammatory disease including Crohn's disease…
- Trial name
- NCT02520843
- Testing
- stromal vascular fraction (SVF)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Anal Fistula
Multicenter Prospective Evaluation of Radiofrequency for Anal Fistulas
Anal fistula treatment is associated with increasing risk of anal incontinence until 40% of cases. New and alternative treatments (glue, advancement flap, plug…) decrease this risk, but with fistula efficacy treatment in 40 to…
- Trial name
- RADIOFIST (NCT03131297)
- Testing
- treatment by radiofrequency
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- F Care Systems NV
High Anal Fistula
TROPIS Versus Coring Out Fistulectomy in High Anal Fistula
High anal fistulas represent a surgical challenge due to high recurrence rates and risk of postoperative fecal incontinence. Several sphincter-preserving techniques have been developed to address these issues.
- Trial name
- TROCO-HAF (NCT07334678)
- Testing
- Transanal opening of intersphincteric space (TROPIS), Coring Out Fistulectomy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Rectal Fistula
Photodynamic Therapy in Anal Fistula
Objective: Validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula. Methods: Prospective observational study including patients treated for complex anal fistula who…
- Trial name
- NCT03864718
- Testing
- photodynamic therapy
- Volunteers
- 49 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Anal Fistula Surgery, Anal Fistula
The Use of Electronic Bidets Compared to Water Rinsing After Surgery for Anal Fistula or Haemorrhoidal Disease: a Pilot Study
There is still much to discover in the field of proctological postoperative care. There has already been some, albeit very little, research about its use post-haemorrhoidectomy as well as its possible effect on anal fissures, but…
- Conditions
- Anal Fistula Surgery, Anal Fistula, Hemorrhoidal Disease, Hemorrhoid Surgery
- Trial name
- bidet (NCT07874711)
- Testing
- Electronic bidet, standard water rinsing
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Fistula in Ano, Transsphincteric Anal Fistula
Treatment of Fistula in Ano With Autologous Fatty Tissue Cells Transplantation
This is a prospective interventional study on the treatment of transsphincteric fistula in ano. After abdominal or thigh liposuction, fat was injected around the fistula tract that was then transected percutaneously with a sharp…
- Trial name
- NCT04660903
- Testing
- Autologous fat cell transplantation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Konstantinos Tsimogiannis
Anal Fistula
Long-term Follow-up of Anal Fistula Plug
Aim of the study is to evaluate long-term success rate of Biodesign® anal fistula plug for treatment of complex trans-sphincteric anal fistulas.
- Trial name
- NCT03961984
- Testing
- Biodesign® anal fistula plug
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane