Clinical trials: Anal Infection
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Papillomavirus Vaccines, Human Immunodeficiency Virus
Immunogenicity of Gardasil-9 HPV Vaccine in People Living With HIV
The primary objective of this study is to determine the magnitude and breadth of the serum antibody response to the nonavalent HPV vaccine (Gardasil-9) in adults with well-controlled HIV infection.
- Conditions
- Papillomavirus Vaccines, Human Immunodeficiency Virus, Papillomavirus Infection, Serology
- Trial name
- AGO-Gard (NCT05266898)
- Testing
- Human papillomavirus 9-valent vaccine, recombinant, human papillomavirus vaccine, recombinant
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
HIV Infections, Papillomavirus Infections
Viral Load Determination and Biomarkers of High Risk Human Papillomavirus (HPV) - Types in HIV-positive Men
Human papillomavirus (HPV)-infection belongs to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men (MSM) are strongly associated with a higher prevalence of genital HPV-infection, a…
- Conditions
- HIV Infections, Papillomavirus Infections, Anal Intraepithelial Neoplasia
- Trial name
- NCT00365729
- Testing
- Smear and biopsy testing for HPV-types and viral load
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Deutsche Luft und Raumfahrt
Papillomavirus Infections, HIV Infections
Prevalence and Longitudinal Follow-up of Anal Lesions, HPV Infection and Associated Sexually Transmitted Infections Among Men Who Have Sex With Men in Togo.
The DepIST-H study, funded by the French AIDS and Hepatitis Research Agency (ANRS), is to estimate prevalence (the number of cases over a given period of time) and incidence (the number of new cases over a given period of time)…
- Trial name
- DepIST-H (NCT04910438)
- Testing
- STIs screening and care
- Where
- Togo
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HPV-Related Carcinoma, HPV Infection
Determining the Frequency of Occurrence and Defining the Most Appropriate Screening Test for Anal Intraepithelial Neoplasia (AIN) in Patients With Human Papillomavirus (HPV) Related Gynecological Diseases.
The primary aim of the study is to determine the total risk of AIN in group of HPV-RGD survivors and additionally to establish an exact risk for each of HPV-related gynecological precancers/cancers.
- Trial name
- NCT06574087
- Testing
- hrHPV test and cytology
- Where
- Poland
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- PCK Marine Hospital in Gdynia
Gonorrhea, Gonorrhea of Pharynx
BIYELA - Bexsero Immunisation in Young Women in Africa
This proposed 2-arm randomized evaluation of two doses of 4CMenB vaccine versus placebo at Enrollment and Month 2 is designed as a proof-of-concept study to inform potential use for dual meningococcal B and gonococcal prevention…
- Conditions
- Gonorrhea, Gonorrhea of Pharynx, Gonorrhea of Anus, Gonorrhea of Cervix
- Trial name
- NCT06446752
- Testing
- Bexsero
- Where
- 5 sites in South Africa
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anal Carcinoma, HIV Infection
Anal Cytology Collection Procedures in Predicting High-Grade Anal Dysplasia in Men Who Have Sex With Men
This clinical trial compares three anal cytology collection procedures (collected at a single visit) in men who have sex with men (MSM).
- Conditions
- Anal Carcinoma, HIV Infection, Human Papillomavirus Infection
- Trial name
- NCT02816879
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Genital Wart, Penile Cancer
A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 9-valent (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Human Papillomavirus (HPV) Recombinant Vaccine (Hansenula Polymorpha) in Chinese male…
- Conditions
- Genital Wart, Penile Cancer, Anal Cancer, PIN-1
- Trial name
- NCT06465914
- Testing
- 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- 5 sites in China
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Adherence, Medication, Risk Reduction
Prevention and Risk: Treatment With a New Emphasis on Relationships
This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention - termed PARTNER - utilizes a brief (4 session) motivational interviewing format to target…
- Conditions
- Adherence, Medication, Risk Reduction, Drug Use, Sex, Anal
- Trial name
- PARTNER (NCT03396367)
- Testing
- PARTNER, Education Intervention
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Anal HSIL, Anal AIN3
Anal Cancer Prevention in High-Risk Categories of Men Who Have Sex With Men
The incidence of anal cancer is increasing, particularly among high-risk groups such as men who have sex with men (MSM), especially those living with HIV.
- Conditions
- Anal HSIL, Anal AIN3, Anal HPV Infection
- Trial name
- DACaP (NCT07123558)
- Testing
- High resolution anoscopy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Human Papilloma Virus, Cervical Cancer
Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention
The project aims to increase HPV vaccination and cervical cancer screening through a web-based mobile health education program called, Wheel of Wellness (WoW) and a brief negotiated interview (BNI).
- Conditions
- Human Papilloma Virus, Cervical Cancer, Human Papillomavirus Infection, Oropharyngeal Cancer
- Trial name
- NCT03346915
- Testing
- WoW and BNI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Human Papillomavirus Infection
Anal HPV Infection and Risk for Anal High-grade Squamous Intraepithelial Lesion Among Thai MSM With Acute HIV Infection
1. To determine the prevalence and incidence of anal HSIL and associated risk factors among MSM who initiate ART during AHI.
- Trial name
- NCT03032575
- Testing
- SEARCH010/RV254
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 3
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER3 (NCT05587725)
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Monash University
Human Immunodeficiency Virus, Stigma, Social
Mitigating Sexual Stigma Within Healthcare Interactions Improve Engagement of MSM in HIV Prevention
The purpose of this study is to explore drivers and mitigators of anal sex stigma in healthcare, and then to develop and pilot an intervention for health workers that mitigates the deterrent effects of this stigma on the…
- Conditions
- Human Immunodeficiency Virus, Stigma, Social, Patient Engagement
- Trial name
- NCT04779736
- Testing
- A set of implementation strategies to reduce sexual stigma
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Anal Carcinoma, Cervical Carcinoma
Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls
This research trial studies extended follow up of young women in Costa Rica who received vaccine for human papillomavirus types 16 and 18 and unvaccinated controls.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Human Papillomavirus Infection, Human Papillomavirus-Related Cervical Carcinoma
- Trial name
- NCT00867464
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Long-term Follow-up
- Where
- Costa Rica
- Volunteers
- 8,670 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Anal Cancer, Nonneoplastic Condition
Comparing Two Types of Swabs in Collecting Cell Samples for Anal Pap Tests and Human Papillomavirus Tests in Men Who Have Sex With Men
RATIONALE: Doctors use a swab to collect cell samples when testing for anal cancer and human papillomavirus. It is not yet known which type of swab is more effective in collecting cell samples for anal Pap tests and human…
- Conditions
- Anal Cancer, Nonneoplastic Condition, Precancerous Condition
- Trial name
- NCT00955591
- Testing
- Papanicolaou test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Human Papilloma Virus
Prevalence of Anal High-risk Human Papilloma Virus Infection and Abnormal Anal Cytology in Men Who Have Sex With Men Using Pre Exposure Prophylaxis
The aim of the study is to determine the prevalence of anal high-risk HPV infection and abnormal cytology in HIV uninfected Men who have sex with men (MSM) using PrEP and HIV infected MSM followed-up at the S-kliniek or HRC of…
- Trial name
- NCT04950101
- Testing
- anal sampling
- Where
- Belgium
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
HIV/AIDS, HIV Prevention
Evaluating Distribution of a Tenofovir Douche With Tap Water Douching and Simulated Receptive Anal Intercourse
DREAM-02 is a phase 1, open label study to evaluate different sequences of tap water douching and simulated receptive anal intercourse (sRAI) in the presence of a tenofovir douche designed to confer protection from Human…
- Trial name
- DREAM-02 (NCT04195776)
- Testing
- Tenofovir Douche
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Human Papillomavirus Infection
A Phase I Trial Evaluate the Safety and Tolerability Profile of HPV Vaccine
This study is to evaluate the safety and tolerability profile of Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli) in healthy women ages 18-45
- Trial name
- NCT05680454
- Testing
- Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli), Recombinant nonavalent Human Papillomavirus (Types 6,11,16,18,31,33,45,52,58) Vaccine
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beijing Health Guard Biotechnology, Inc
HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer
A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand
The purpose of this research is to assess the safety and effectiveness of circumferential radiofrequency ablation (RFA) to the anal canal using the BarrxTM Ablation System to destroy anal high-grade squamous intraepithelial…
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer, HPV-Related Squamous Cell Carcinoma, Human Papilloma Virus
- Trial name
- NCT03302858
- Testing
- BARRX™ Anorectal Wand
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stephen E. Goldstone