Clinical trials: Analgesia, Postoperative
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Post Operative Pain, Caesarean Section
Naldebain® Extended-release Injection After Cesarean Section in Pain Management
Cesarean section is one of the surgeries most commonly leading to postoperative severe acute pain. It was reported that the mean worst pain intensity reached to 6.14 one day after cesarean section in Germany.
- Conditions
- Post Operative Pain, Caesarean Section, Analgesia
- Trial name
- NCT05446311
- Testing
- Dinalbuphine sebacate
- Volunteers
- 20 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Pain, Analgesia
Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery
Inadequate pain control after abdominal procedures may lead to adverse postoperative outcome. Epidural analgesia is currently an accepted technique in abdominal surgery, but its use has been limited in liver resections by…
- Conditions
- Pain, Analgesia, Sedation
- Trial name
- NCT01201499
- Testing
- Intrathecal morphine, Continuous IV remifentanil
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Total Hip Arthroplasty, Postoperative Pain
PENG, Suprainguinal Fascia Iliaca Block, and Control After Total Hip Arthroplasty
Total hip arthroplasty can cause significant pain after surgery. Regional anesthesia techniques, such as the pericapsular nerve group (PENG) block and the suprainguinal fascia iliaca plane block, may help reduce postoperative…
- Trial name
- NCT07879521
- Testing
- Pericapsular nerve group (PENG) block, Suprainguinal Fascia Iliaca Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Uludag University
Pain Management, Analgesia
Comparison of a Comfort Scale and a Numerical Pain Scale on Opioid Consumption After Surgery
The objective is to show that the use of therapeutic communication tools, in this case a comfort scale, a low cost and simple to implement method, can reduce pain and therefore the consumption of opioids in the postoperative care…
- Trial name
- COMFORT (NCT05234216)
- Testing
- Informed consent, Surgery, Comfort scale
- Where
- 29 sites in France, Lebanon
- Volunteers
- 885 people
- Sponsor
- Rennes University Hospital
Cesarean Section, Cesarean Delivery
Pain Management After Cesarean Section - A Before-and-After Cohort Study
Inadequate pain relief remains a challenge after Cesarean section (CS) and may significantly impair postoperative recovery. A recent Danish single-center study (n=100) revealed that 66% of elective CS patients experienced severe…
- Conditions
- Cesarean Section, Cesarean Delivery, Pain Management, Pain Management in Postoperative Care
- Trial name
- NCT06813638
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Nordsjaellands Hospital
Acute Pain
Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction
This study aims to evaluate the analgesic efficacy of single and multiple doses of a new fixed dose combination of nefopam hydrochloride 30 mg and paracetamol 500mg taken orally in comparison to each single component.
- Trial name
- NCT04622735
- Testing
- nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 321 people
- Sponsor
- Unither Pharmaceuticals, France
Osteoarthritis, Knee, Nociceptive Pain
The Post-operative Analgesia of the Virtual Reality Using a Mirror Therapy After Total Knee Arthroplasty
It was well known that the mirror therapy could decrease pain of upper-limb amputated patients. The mirror therapy is known to make a plastic change some parts of the brain perceiving the painful body part and modulating its…
- Conditions
- Osteoarthritis, Knee, Nociceptive Pain, Virtual Reality
- Trial name
- NCT01979718
- Testing
- Mirrored Virtual reality
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ulsan University Hospital
Acute Pain, Postoperative Pain
Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain
This study will evaluate two different analgesic regimen used for acute postoperative pain.
- Trial name
- NCT03063658
- Testing
- Paracetamol, Ibuprofen 800 mg
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara University
Post-surgical Pain, Total Knee Arthroplasty
Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
Currently, continuous adductor canal and popliteal-sciatic nerve blocks are used commonly for lower extremity post-operative pain control, specifically for total knee arthroplasty and foot/ankle surgery, respectively.
- Conditions
- Post-surgical Pain, Total Knee Arthroplasty, Foot/Ankle Surgery, Catheterization for Postop Analgesia
- Trial name
- NCT02523235
- Testing
- ropivacaine 0.2%
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of California, San Diego
Arthroplasty, Knee Osteoarthritis
Suprainguinal Fascia Iliaca Block vs. Adductor Canal Block for Analgesia After Total Knee Arthroplasty
This study evaluates the analgesic efficacy and motor-sparing properties of ultrasound-guided Suprainguinal Fascia Iliaca Block (S-FIB) compared with Adductor Canal Block (ACB) in patients undergoing primary total knee…
- Trial name
- NCT07739108
- Testing
- PCA
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Postoperative Pain
Tegileridine vs Sufentanil for Postoperative Pain Management and Gastrointestinal Recovery After Major Laparoscopic Abdominal Surgery
This study is a single-center, randomized, triple-blind clinical trial designed to compare tegileridine and sufentanil for postoperative analgesia and gastrointestinal tolerability in patients undergoing major laparoscopic…
- Trial name
- TASPER (NCT07637968)
- Testing
- Tegileridine, Sufentanil, Palonosetron
- Volunteers
- 84 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Shoulder Pain
Postoperative Analgesic Effect of Infraspinatus-teres Minor Inter-fascial Block in Patients Undergoing Shoulder Surgery
It is proposed to investigate the effectiveness of ultrasound-guided intertrochanteric block of the infraspinatus minor round myofascial block not inferior to the interosseous groove brachial plexus nerve block in postoperative…
- Trial name
- NCT06240884
- Testing
- Infraspinatus-teres minor interfascial block, interscalene block
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiaxing University
Post-operative Pain Management
Intercostal Cryoanalgesia in Double Lung Transplant Recipients
This study is testing a new way to help manage pain after a double lung transplant. Instead of relying only on strong pain medicines like opioids, doctors will use a cold-therapy probe during surgery to help numb the nerves near…
- Trial name
- NCT07281118
- Testing
- Atricure CryoSPHERE MAX Probe
- Where
- 3 sites in United States
- Volunteers
- 148 people
- Sponsor
- University of California, Los Angeles
Pediatric Surgical Patients, Preemptive Epidural Analgesia
The Impact of Preemptive Epidural Analgesia on Acute Postoperative Pain in Pediatric Orthopedic Surgery
Management of postoperative pain is critical in the pediatric patients, however, safe and effective analgesia for pediatric surgical patients remains a challenge.
- Trial name
- NCT02813018
- Testing
- 0.2 ml/kg of 0.2% ropivacaine, 0.2mg/kg of Normal Saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Pain Management, Pain, Postoperative
Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
This is a prospective randomized open-label noninferiority trial that compares intrathecal morphine injection and continuous wound infiltration after open pancreaticoduodenectomy.
- Trial name
- ITM_PPPD (NCT06761989)
- Testing
- Intrathecal morphine injection, Continuous wound infiltration
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Seoul National University Hospital
Postoperative Care, Hysterectomy
Information for Patient Controlled Analgesia Device
This study is aimed to show the effect of information method on properly usage of the patient controlled analgesia(PCA) device
- Conditions
- Postoperative Care, Hysterectomy, Health Communication
- Trial name
- NCT03807960
- Testing
- written form, video, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Tuğba Karaman
Postoperative Pain
Personalizing Perioperative Analgesia in Children
In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief.
- Trial name
- NCT01140724
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Senthil Sadhasivam
Post Operative Pain
The Safety and Efficacy of Surgical Rectus Sheath Block for Postoperative Analgesia After Elective Cesarean Delivery
All participants will receive spinal anaesthesia and will be randomly divided into 2 equal groups. In Group 1, 20 ml of local anesthetic solution will be administered bilaterally to the rectus sheath space under direct vision…
- Trial name
- NCT06020196
- Testing
- surgical rectus sheath block, subdermal local anaesthetic infiltration
- Where
- Egypt
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ahmed M Maged, MD
Acute Post-operative Pain Following Caesarean Section
Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
Background: Multimodal analgesia; a combination of opioid and non-opioid analgesics, for management of acute post-operative pain significantly reduces the incidence of adverse effects associated with liberal post-operative opioid…
- Trial name
- OFAAPPCS (NCT04539249)
- Testing
- Magnesium sulphate, Pentazocine
- Where
- Nigeria
- Volunteers
- 324 people
- Sponsor
- Olakunle Ifeoluwa Makinde
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