Clinical trials: Analgesia, Postoperative
Postoperative Pain, Postoperative Complications
Intraoperative Fentanyl Consumption Guided by Analgesia Nociception Index
Balanced anesthesia needs optimization of hypnotic, relaxant, and narcotic. Administration of hypnotic drugs can be monitored by bispectral index score (BIS), while the dosage of muscle relaxants can be guided by train-of four…
- Trial name
- NCT03716453
- Testing
- Standard protocol, ANI protocol
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Total Knee Arthroplasty for Gonarthrosis
"The Effect of Adductor Canal Block Performed With Postoperative Thigh Tourniquet Application on Pain After Total Knee Arthroplasty"
The biggest fear for patients undergoing knee replacement surgery is that persistent pain felt at the back of the knee postoperatively.
- Trial name
- NCT07539467
- Testing
- Tourniquet-Assisted Adductor Canal Block (T-ACB) grou, Standard Adductor Canal Block (S-ACB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pain
Comparison of Two Drugs Bupivacaine and Ropivacaine for Postoperative Analgesia in Bilateral Superficial Cervical Plexus Block After Thyroidectomy
There is significant difference between bupivacaine and ropivacaine in terms of postoperative pain assessment in patients undergoing total thyroidectomy with bilateral superficial cervical plexus block.
- Trial name
- NCT07779551
- Testing
- Group 1 will receive 10ml of 0.25% bupivacaine, Group 2 will receive 10ml of 0.25% ropivacaine on each side.
- Where
- Pakistan
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Sargodha Medical College
Postoperative Pain, Analgesia
Lidocaine Irrigation in Shoulder Arthroscopy
Arthroscopic shoulder surgery is often associated with severe postoperative pain that is often significant enough to interfere with initial recovery and rehabilitation.
- Trial name
- NCT05624957
- Testing
- Lidocaine epinephrine, Epinephrin
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Minia University
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Postoperative Pain, Acute Cholecystitis
USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (LC) can cause moderate-to-severe postoperative pain from visceral, referred shoulder, and incisional sources. Multimodal analgesia is recommended, but opioids carry significant side effects.
- Conditions
- Postoperative Pain, Acute Cholecystitis, Cholelithiasis, Postoperative Nausea and Vomiting
- Trial name
- NCT07552701
- Testing
- M-TAPA Group, RIFPB Group
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Hitit University
Surgery
ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery
This study is being done to compare 2 types of pain control methods and determine which is more effective postoperatively for laparoscopic colorectal surgery.
- Trial name
- NCT05257941
- Testing
- IT Injection, ESP Block
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Indiana University
Laparoscopic Cholecystectomy
Multimodal Analgesia for Cholecystectomy
It is important to decrease the postoperative pain in patients undergoing laparoscopic cholecystectomy. We will compare the pharmacologic analgesia with the parmacologic and surgical analgesia in patients undergoing laparoscopic…
- Trial name
- NCT04788654
- Testing
- Celebrex, acetaminophen, and dexamethasone, Saline irrigation, aspiration of pneumoperitoneum, and low pressure penumoperitoneum
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Postoperative Nausea and Vomiting
Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)
PCA morphine always introduces nausea and vomiting during the postoperative period. Ondansetron can reduce PONV (postoperative nausea vomiting).
- Trial name
- NCT00199329
- Testing
- ondansetron adding in PCA
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Khon Kaen University
Pain, Postoperative
A Comparison of the Safety and Effectiveness of Two Forms of Patient-controlled Pain Medication Used After Scheduled Abdominal or Pelvic Surgery: The Fentanyl Transdermal System Versus the Morphine Intravenous Pump
The purpose of this study is to compare two pain medications delivered by two different forms of patient-controlled pain management systems: the Fentanyl HCl Patient-Controlled Transdermal System (E-TRANS fentanyl) and the…
- Trial name
- NCT00266539
- Testing
- E-TRANS Fentanyl hydrochloride; Morphine
- Volunteers
- 506 people
- Sponsor
- Alza Corporation, DE, USA
Pain, Postoperative
Modified TAP (Transverse Abdominis Plane) Block in Colorectal Surgery
Single Blind, Randomized Controlled study to see if TAP Block with Exparel provides better pain relief than TAP Block with bupivicaine.
- Trial name
- NCT04781075
- Testing
- Pain Scale, Exparel Injectable Product, Bupivacaine Injection
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Obesity
Ibuprofen and Erector Spinae Plane Block After Laparoscopic Sleeve Gastrectomy
Laparoscopic sleeve gastrectomy (LSG) is defined as the first-step bariatric surgery for patients in the high surgical risk group.
- Trial name
- NCT04232072
- Testing
- Group ESPB, Group Ibuprofen
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Complications; Cesarean Section
Preoperative Cesarean Section Intravenous Acetaminophen and Postoperative Pain Control
To evaluate the use of maternal opiates for pain control post cesarean delivery in those patients that received intravenous acetaminophen 1000 mg in 150 mL of normal saline, infused 30 minutes prior to incision compared to…
- Trial name
- NCT02694653
- Testing
- Acetaminophen
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Scheduled Cesarean Sections, Postoperative Pain Management
Low Pain Prediction in Cesarean Section Patients
The investigators are attempting to see if eliminating the amount of long acting spinal narcotic during cesarean section delivery will demonstrate pain scores with movement when evaluated 24 hours postoperatively as those that…
- Conditions
- Scheduled Cesarean Sections, Postoperative Pain Management, Side Effects
- Trial name
- NCT02143141
- Testing
- duramorph
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain
Lumbar Plexus Block for Postoperative Pain Control After Hip Arthroscopy. A Randomized Controlled Trial
The purpose of this study is to determine whether the use of a lumbar plexus block for arthroscopic hip surgery is superior to oral and intravenous opioid pain medications alone in treating pain.
- Trial name
- LPB Hip Scope (NCT01286805)
- Testing
- Lumbar Plexus Blockade, Control
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- Hospital for Special Surgery, New York
Anxiety, Cesarean Section Complications
The Effect of Pre-operative Videotape Before a Planned Cesarean Section on Anxiety Level
The study aim is to examine the relationship between providing information to women prior to elective cesarean delivery and anxiety levels around surgery. the patients will be assigned into two groups - intervention and control.
- Conditions
- Anxiety, Cesarean Section Complications, Pain, Postoperative, Analgesia
- Trial name
- NCT04177966
- Testing
- pre-prepared video describing the cesarean surgery, general information
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Postoperative Pain, Acute
Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures
The goal of this clinical trial is to compare the analgesic efficacy of adding dexmedetomidine versus ibuprofen to bupivacaine for intraperitoneal instillation after laparoscopic gynecological procedures.
- Trial name
- NCT06046105
- Testing
- Administering intraperitoneal bupivacaine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Dexmedetomidine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Ibuprofen for pain control after laparoscopic gynecological procedures
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Pain Management in Adult Females in Child Bearing Period Aging From 20 to 45 Years Who Are Scheduled for Elective Cesarean Section
Intrathecal Dexmedetomidine Versus Transversus Abdominus Plane Block (TAP) for Postoperative Analgesia After Cesarean Section.
Spinal anesthesia is the most commonly used technique for lower abdominal surgeries as it is very economical and easy to administer.
- Trial name
- NCT04969705
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Obstructive Sleep Apnea
Multimodal Postoperative Analgesia Following OSA Surgery
Assessment of the clinical efficacy and adverse effects of multimodal analgesic regimen consisting of nalbuphine combined with ketorolac using IV continuous infusion silicon device (Accufuser) for postoperative analgesia…
- Trial name
- NCT04483427
- Testing
- Nalbuphine, ketorolac, accufuser
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Bahaa Mohammed Refaie
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