Clinical trials: Analgesia, Postoperative
Primary Total Knee Arthroplasty
The Efficacy of Local Infiltration Analgesia for Postoperative Pain Management After Total Knee Arthroplasty
This prospective, double-blinded, randomized controlled study evaluates the effects of peripheral nerve blocks with and without local infiltration analgesia for postoperative pain management after primary total knee arthroplasty.
- Trial name
- NCT04258241
- Testing
- Local infiltration analgesia with local anesthetic, Local infiltration analgesia without local anesthetic, Needle
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Lithuanian University of Health Sciences
Post Operative Pain Management
Efficacy of Erector Spinae Plane Block Versus Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy
The investigators hypothesize that erector spinae plane block is better than subcostal transversus abdominis plane block regarding postoperative pain management.
- Trial name
- NCT06670508
- Testing
- Subcostal Transversus Abdominis Plane block, Erector Spinae Plane block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Pain, Postoperative
Effects of Continuous Bilateral QL Analgesia After Open Abdominal Surgery
Eligible patients will be randomized 1:1 without stratification to bilateral continuous QL catheters with local anesthetic continuous infusion (QL block + IV patient-controlled analgesia group) or normal saline continuous…
- Trial name
- NCT02684968
- Testing
- Colorectal surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
TSA, Bruise
Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia
This study aims to identify the timeline of pain following total shoulder replacement with the goal of developing data for a subsequent randomized trial.
- Conditions
- TSA, Bruise, Pain, Postoperative
- Trial name
- TSA (NCT03021096)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Post Operative Pain
The Safety and Efficacy of Surgical Rectus Sheath Block for Postoperative Analgesia After Elective Cesarean Delivery
All participants will receive spinal anaesthesia and will be randomly divided into 2 equal groups. In Group 1, 20 ml of local anesthetic solution will be administered bilaterally to the rectus sheath space under direct vision…
- Trial name
- NCT06020196
- Testing
- surgical rectus sheath block, subdermal local anaesthetic infiltration
- Where
- Egypt
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ahmed M Maged, MD
Postoperative Pain
PAIN - Postoperative Analgesia INvestigation
The purpose of this study is to assess the efficacy of the intraoperative injection of prolonged acting (liposomal) bupivacaine in postoperative pain control after truncal surgical incisions.
- Trial name
- PAIN (NCT02111746)
- Testing
- Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Vaginal Hysterectomy, Postoperative Pain
Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Hysterectomy performed through the vaginal route (HVR) is the preferred method for women seeking hysterectomy to address uterine concerns such as premalignant conditions and fibroids.
- Conditions
- Vaginal Hysterectomy, Postoperative Pain, vNOTES
- Trial name
- NCT06429605
- Testing
- duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Quadratus Lumborum Block, Transversus Abdominis Plane Block
Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial
Background: Multimodal analgesia (MMA) is the current standard practice to provide postoperative analgesia. The aim of this study is to compare the analgesic efficacy of quadratus lumborum (QL) block versus transversus abdominis…
- Conditions
- Quadratus Lumborum Block, Transversus Abdominis Plane Block, Caudal Block, Postoperative Pain
- Trial name
- NCT05442905
- Testing
- propofol, Atracurium Besylate, sevoflurane
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Postoperative Pain Management
Ultrasound-Guided Erector Spinae Plane Block Versus Intravenous Nalbuphine
2.1. Study population and setting: This prospective, randomized, controlled clinical trial will be conducted at the thoracic surgery operation room, cardiothoracic surgery building, Zagazig University Hospitals, from July 2025 to…
- Trial name
- VATS (NCT07391475)
- Testing
- Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Zagazig University
Post-operative Pain, Acute, Post-operative Pain
Postoperative Analgesia y After Uniportal Video-assisted Thoracoscopic Surgery
Ultrasound-guided erector spinae plane block (ESPB) is an interfascial blockade during thoracic anesthesia, first described by Forero in 2016, and is highlighted by technically feasibility and less complication rate.
- Conditions
- Post-operative Pain, Acute, Post-operative Pain, Thoracic Diseases, Post-Op Complication
- Trial name
- NCT05242328
- Testing
- Ultrasound-guided erector spinae plane block, surgical thoracoscopic intercostal nerve block
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Pain
Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery
Can perioperative administration of intra-peritoneal local anaesthetics further reduce postoperative pain, inflammation and outcome in patients undergoing major abdominal surgery (cytoreductive surgery) and managed with thoracic…
- Trial name
- IPLA (NCT02256228)
- Testing
- Ropivacaine, Saline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Pain
The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate…
- Trial name
- NCT01872494
- Testing
- local, intravenous, 0.33% ropivacaine 250ml
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Arthroplasty, Replacement, Knee
Intraarticular Analgesia After Total Knee Arthroplasty, a Randomised Study
The study aims to compare two different kinds of pain treatment after total knee replacement (operation with artificial knee joint): 1) a large local injection in and around the knee, supplemented with injection the day after, or…
- Trial name
- NCT00269529
- Testing
- femoral nerve block, knee infiltration and injection via catheter
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Pain After Knee Arthroplasty
Adductor Canal Block and IPACK Block vs Adductor Canal Block and the Gastrosoleus Interfascial Block After Total Knee Arthroplasty
Evaluate analgesic efficacy of adductor canal block with IPACK versus that of adductor canal block with gastrosoleus interfascial plane block in total knee arthroplasty surgeries.
- Trial name
- NCT07336901
- Testing
- Adductor Canal Block (ACB) + gastrosoleus interfascial plane block, Adductor Canal Block (ACB) + iPACK Block
- Volunteers
- 86 people
- Sponsor
- Fayoum University Hospital
Post Operative Analgesia, Non-inferiority Trial
Efficacy of Transversus Abdominis Plane (TAP) Block Techniques: Surgeon vs Anesthesia - Ultrasound Guidance
The transversus abdominis plane (TAP) block is a regional anesthesia technique where local anesthetic is injected into the neurovascular plane between the transversus abdominis and internal oblique muscles.
- Trial name
- NCT03577912
- Testing
- TAP block administered by Surgery, TAP block administered by Anesthesia
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pain After Abdominal Surgery
A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China.
A multicenter, randomized, double-blind, placebo-positive, parallel-controlled, phase Ⅲ clinical trial of the efficacy, safety and pharmacokinetics of TRD303 solution for postoperative analgesia in patients undergoing abdominal…
- Trial name
- NCT07353307
- Testing
- TRD303 solution, Ropivacaine hydrochloride, 0.9 % sodium chloride
- Where
- 2 sites in China
- Volunteers
- 333 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Bone Defect, Bone Tumor of Extremity
Clinical Efficacy Study of Magnesium-Containing Degradable Polymer Bone Repair Material for Bone-Defect Repair After Extremity Bone Tumor Resection
This is a single-center prospective randomized open-label non-inferiority clinical trial for adult patients with bone defects after extremity bone tumor resection.
- Conditions
- Bone Defect, Bone Tumor of Extremity, Bone-Like Tumor Lesion
- Trial name
- MAGBONE (NCT07794202)
- Testing
- Magnesium-containing degradable polymer bone repair material, Conventional non-magnesium bone repair material
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Yu Zhang, PhD
Pain, Acute, Opioid Use
Femoral Triangle Block With Popliteal Plexus Block Versus Femoral Triangle Block Versus Adductor Canal Block for TKA
In this study we wish to investigate the analgesic effect 3 different nerve block regimes in patients following primary total knee arthroplasty (TKA).
- Conditions
- Pain, Acute, Opioid Use, Analgesia
- Trial name
- NCT04854395
- Testing
- Marcain 5 mg/ml
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Regionshospitalet Silkeborg
Surgery
QL vs LP Blocks for Analgesia Following THA
Purpose: Evaluate difference in postoperative opioid consumption when subjects receive a quadratus lumborum (QL) or lumbar plexus (LP) block preoperatively for total hip arthroplasty (THA).
- Trial name
- NCT04402437
- Testing
- LP Block, QL Block
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pelvic Pain, Endometriosis
Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery
This will be a prospective, randomized, double blinded placebo-controlled study at Erlanger hospital. Eligible patients who provide consent will be randomized into one of two arms receiving continuous intra-peritoneal local…
- Conditions
- Pelvic Pain, Endometriosis, Pelvic Prolapse
- Trial name
- NCT04118777
- Testing
- Ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee, Chattanooga
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