Clinical trials: Analgesia Assessment
Low Back Pain, Pain
Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)
The purpose of this study is to determine if a stepped-care intervention makes pain symptoms better and reduces activity limitations because of pain. Our two primary hypotheses are that in OIF/OEF veterans with chronic pain: 1.
- Conditions
- Low Back Pain, Pain, Pain, Intractable
- Trial name
- ESCAPE (NCT00386243)
- Testing
- Cognitive behavioral therapy, Pain self-management program, Co-Analgesic Therapy
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- VA Office of Research and Development
Hallux Valgus
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy Compared With Placebo
The purpose of this study is to evaluate the analgesic efficacy and safety of tapentadol immediate-release (IR [CG5503]) for use in the relief of moderate to severe acute pain, compared with placebo, in adult Taiwanese patients…
- Trial name
- NCT01813890
- Testing
- Tapentadol IR 50 mg, Tapentadol IR 75 mg
- Where
- 3 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Janssen-Cilag International NV
Gulf War, Fatigue
Groups for Regaining Our Wellbeing
This study is a randomized clinical trial measuring outcomes up to 6-months post-intervention. The objective of this study is to evaluate outcomes of two different group interventions for Veterans with Chronic Multisymptom…
- Conditions
- Gulf War, Fatigue, Pain, Depression
- Trial name
- GROW (NCT03058952)
- Testing
- Mindfulness-Based Stress Reduction, Chronic Disease Self-Management Program
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- VA Office of Research and Development
Chronic Low Back Pain
Virtual Reality Therapy for Chronic Low Back Pain
This study will test the efficacy of an evidence-based virtual reality (VR) therapy program as a non-pharmacological supplement for the management of chronic lower back pain.
- Trial name
- NCT04409353
- Testing
- Distraction-Based VR, Skills-Based VR, Activity Tracker
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Post-operative
Evaluation of N1539 Following Bunionectomy Surgery
The primary objective of this study is to evaluate the analgesic efficacy of N1539 in subjects with acute moderate to severe pain following unilateral bunionectomy.
- Trial name
- NCT02675907
- Testing
- N1539
- Where
- 4 sites in United States
- Volunteers
- 201 people
- Sponsor
- Baudax Bio
Back Pain, Epidural Analgesia, Obstetric
Ultrasound-Guided Landmark and Epidural Site Pain
Historically, women who have chronic back pain after pregnancy have attributed the cause to the epidural procedure. While many studies have shown no greater incidence of generalized post-partum back pain in those who received an…
- Trial name
- NCT02813681
- Testing
- US-epidural SVD, Spontaneous vaginal delivery without an Epidural
- Volunteers
- 80 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Postoperative Pain
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
The primary objective is to demonstrate that SKY0402 is superior when compared to bupivacaine HCl in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Trial name
- TKA (NCT00745290)
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 19 sites in United States
- Volunteers
- 245 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain
Hydrocodone For Pain Control in First Trimester Surgical Abortion
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.
- Trial name
- NCT01330459
- Testing
- Hydrocodone/acetaminophen, Ibuprofen, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Elizabeth Micks
Osteoarthritis, Rheumatoid Arthritis
Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain
The purpose of this study is to assess the efficacy of the buprenorphine transdermal patch (Norspan® or Sovenor® transdermal patch) in patients with chronic non-malignant pain of moderate to severe intensity due to…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain, Joint Pain
- Trial name
- NCT01961271
- Testing
- Buprenorphine transdermal patch
- Where
- 16 sites in Hong Kong, Philippines and 1 more
- Volunteers
- 114 people
- Sponsor
- Mundipharma Pte Ltd.
Orthopedic Surgery of Lower Extremity
Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
A nerve block catheter is a small tube placed next to a nerve through a needle, and the needle is then removed. Numbing medicine is dripped through the tube to reduce pain sensation from the nerve.
- Trial name
- NCT01167907
- Testing
- 0.2% ropivacaine, saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Undergoing Hysterectomy
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing hysterectomy on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993226
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 115 people
- Sponsor
- Durect
Chronic Pain
Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy
The purpose of this study is to investigate whether the StimRouter (SR) electrical stimulation therapy leads to clinically important pain relief in patients with chronic intractable pain of peripheral nerve origin after three…
- Trial name
- NCT01592344
- Testing
- StimRouter - active stimulation, StimRouter - Control
- Where
- 13 sites in United States
- Volunteers
- 94 people
- Sponsor
- Bioness Inc
Contraception, Inhalation of Nitrous Oxide
Nitrous Oxide for Pain Management During In-office Transcervical Sterilization
This is a randomized, double blind study that aims to measure the difference in maximum pain experienced during in-office transcervical sterilization (Essure®) for women receiving either inhaled nitrous oxide or standard oral…
- Trial name
- NEST (NCT02312739)
- Testing
- In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pain, Postoperative
Safety and Efficacy Study of Fentanyl Iontophoretic Transdermal System (ITS) for Management of Moderate to Severe Acute Pain in Participants Who Have Undergone Elective Spine or Orthopedic Surgery
The purpose of this study is to evaluate in daily clinical practice the safety and efficacy of fentanyl Iontophoretic Transdermal (through the skin) System (ITS) for management of moderate (medium level of seriousness) to severe…
- Trial name
- NCT00779038
- Testing
- Fentanyl ITS
- Where
- 3 sites in Belgium
- Volunteers
- 13 people
- Sponsor
- Janssen Cilag N.V./S.A.
Peripheral Arterial Disease, Intermittent Claudication
Pain Management and Patient Education for Physical Activity in Intermittent Claudication (PrEPAID)
Peripheral Arterial disease is a common condition which causes narrowing of the arteries. The most common symptom that patients with PAD experience is Intermittent Claudication (IC), pain in the lower limb(s) on exertion, which…
- Trial name
- PrEPAID (NCT03204825)
- Testing
- Active TENS, Patient-Centred Education
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- Glasgow Caledonian University
Contraception
Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion
The purpose of this study is to determine whether Nitrous Oxide is effective in achieving pain control and satisfaction among nulliparous women getting the intrauterine device (IUD).
- Trial name
- NIUD (NCT02391714)
- Testing
- IUD insertion, Povidone-Iodine, Chlorhexidine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Naive Subjects
The purpose of this study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-naive subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01633944
- Testing
- Buprenorphine
- Where
- 60 sites in United States
- Volunteers
- 752 people
- Sponsor
- BioDelivery Sciences International
Analgesia
HTX-011 for Post-bunionectomy Analgesia
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
- Trial name
- HTX-011 (NCT02471898)
- Testing
- HTX-011
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Heron Therapeutics
Anesthesia, Analgesia
Prospective Clinical Evaluation of BD NRFit™ Devices and Accessories.
Multi-center, prospective, open label, single arm post-market study to assess the real-world safety and efficacy of BD NRFit™ Spinal Needles, BD NRFit™ Spinal Introducer Needles, and BD NRFit™ Syringes used in an on-market…
- Trial name
- NCT05953363
- Testing
- BD NRFit™ Spinal Needles, BD NRFit™ Spinal Introducer Needles, and BD NRFit™ Syringes
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 161 people
- Sponsor
- Becton, Dickinson and Company
Postoperative Pain
Evaluation of the Safety and Efficacy of a Single Dose of SKY0402 in Subjects Undergoing Augmentation Mammoplasty
The primary objective of this study was to demonstrate the superiority of SKY0402 over conventional, commercially-available bupivacaine HCl with respect to the duration of the analgesic effect achieved by a single local…
- Trial name
- NCT01206608
- Testing
- SKY0402 + bupivacaine HCl, Mid-dose SKY0402 + bupivacaine HCl
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pacira Pharmaceuticals, Inc