Clinical trials: Analgesia Disorder
Musculoskeletal Pain, Chronic Pain
N-of-1 Trials Using mHealth in Chronic Pain
Chronic musculoskeletal pain is an important problem, and treatments are often prescribed in a "trial and error" fashion. Clinicians prescribe a treatment to a patient and then wait and see if the treatment is successful.
- Trial name
- PREEMPT (NCT02116621)
- Testing
- Trialist Intervention, smartphone
- Where
- 2 sites in United States
- Volunteers
- 215 people
- Sponsor
- University of California, Davis
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer
RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00726830
- Testing
- methadone hydrochloride, morphine sulfate, oxycodone hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Pain, Constipation
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs.
- Conditions
- Pain, Constipation, Nausea, Vomiting
- Trial name
- NCT01114997
- Testing
- Lidocaine, Esmolol, Lidocaine + Esmolol (Combo)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Cedars-Sinai Medical Center
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Liver Cancer, Pancreatic Cancer
Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas
The goal of this clinical research study is to learn if there is a difference in patients' quality of recovery if they receive 1 of 2 standard kinds of pain control treatments after surgery on the liver and/or pancreas.
- Trial name
- NCT01438476
- Testing
- Intravenous Patient-Controlled Analgesia (IVPCA), Thoracic Epidural Analgesia (TEA), Questionnaires
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- M.D. Anderson Cancer Center
Bone Marrow Disease, Pain
Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration
St. Jude Children's Research Hospital is studying the best ways to prevent pain during and after procedures such as bone marrow aspiration and lumbar puncture with intrathecal (in the spinal fluid) chemotherapy.
- Trial name
- NCT00187135
- Testing
- Fentanyl, EMLA, L.M.X4
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- St. Jude Children's Research Hospital
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Phlebotomy
Synera Venipuncture Pain
Synera, which is a heated topical patch containing both lidocaine and tetracaine, is intended to reduce the pain associated with venipuncture and superficial dermatologic procedures by numbing the skin.
- Conditions
- Pain, Phlebotomy, Palliative Care
- Trial name
- NCT01744197
- Testing
- Synera (lidocaine 70mg/tetracaine 70mg)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Oncology Research
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Epidural anesthesia, the most common method of pain control in labor, can contribute to alterations in maternal blood pressure and/or fetal heart rate changes.
- Trial name
- NCT02565485
- Testing
- Lactated Ringer's
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- MetroHealth Medical Center
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Duration of Pain Relief
Dexamethasone and Block Duration in Upper Extremity
Effect of dexamethasone on prolonging upper extremity block is well known. But it not known if the effect comes from its local effect on the nerves or from its general analgesic effect.
- Trial name
- NCT01756573
- Testing
- Dexamthsone, Bupivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Abdominal Hysterectomy (& Wertheim)
Lidocaine and Ketamine in Abdominal Surgery
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy.
- Trial name
- NCT00721110
- Testing
- Lidocaine, Ketamine, Ketamine + Lidocaine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Post Operative Pain
Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied.
- Trial name
- NCT00385541
- Testing
- Morphine PCA, Hydromorphone PCA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Postoperative Pain, Postoperative Nausea
Postoperative Pain Control Following Hysteroscopy
Intraoperative lidocaine infusion is a frequently preferred method in surgical procedures due to its reducing the need for opioids, providing better postoperative pain control, reducing postoperative nausea and vomiting and…
- Conditions
- Postoperative Pain, Postoperative Nausea, Analgesia
- Trial name
- NCT06423456
- Testing
- Lidocaine IV, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Thoracotomy, Pain, Postoperative
Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy
Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night.
- Trial name
- NCT05172570
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Postoperative Pain, Breast Cancer
Administration of Ketamine to Prevent the Post-operative Pain
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse…
- Trial name
- KETAMINE (NCT00210210)
- Testing
- Ketamine, Saline solution
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Institut Bergonié
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Lumbar Osteoarthritis, Spondylosis
Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Patients undergoing spine surgery often have considerable pain post-operatively and frequently require opioid medication (Percocet, Norco, oxycodone, morphine, etc.) to control their pain postoperatively.
- Conditions
- Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
- Trial name
- NCT02700451
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Hospital for Special Surgery, New York
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa