Clinical trials: Analgesic
Healthy
Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches
The study is designed to evaluate and compare the clinical adhesion performance of the ZTlido (Lidocaine Topical System) 1.8% of Scilex Pharmaceuticals Inc.
- Trial name
- NCT05106400
- Testing
- ZTlido (Lidocaine Topical System) 1.8%, Salonpas (Lidocaine Patch 4%), Aspercreme (Lidocaine Patch 4%)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Opioid Use, Unspecified
the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block
The purpose of the study is to determine if perineural dexmedetomidine can provide increased prolongation of analgesia when compared to perineural dexamethasone in patients receiving regional block for shoulder surgery.
- Trial name
- NCT02653144
- Testing
- Ropivacaine, Dexmedetomidine, Dexamethasone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Montefiore Medical Center
Pain, Neuropathic Pain
Study to Evaluate Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Peripheral Neuropathic Pain
The primary aim of this study is to investigate if AZD1386 is efficacious as an analgesic in patients with peripheral neuropathic pain.
- Trial name
- AVANT (NCT00976534)
- Testing
- AZD1386
- Where
- 12 sites in Canada, Denmark and 2 more
- Volunteers
- 90 people
- Sponsor
- AstraZeneca
Pain
Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block
the aim of this study is evaluate postoperative analgesic effects of dexmedetomidine added to bupivacaine on TAP block in patients undergoing lower abdominal surgery.
- Trial name
- TAP (NCT02064530)
- Testing
- Bupivacaine, Dexmedetomidine, serum physiologic
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- TC Erciyes University
Tizanididne, Levobupicaine
Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study
Tizanidine, alpha-2 adrenergic receptor agonist, provides analgesic and hemodynamic benefits, which could enhance the efficacy of local anaesthetics.
- Conditions
- Tizanididne, Levobupicaine, Lower Limb Surgery, Pain, Chronic
- Trial name
- NCT07310628
- Testing
- Tizanidine
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences
Profound Muscle Relaxation, Muscle Trauma
Influence of Profound Muscle Relaxation on Muscle Trauma and Postoperative Pulmonary Function
Although deep anesthesia can produce skeleton muscle relaxation,unnecessary deep anesthesia often had adverse cardiac effects and was related to 2-year mortality in cancer patients.The use of muscle relaxants allowed the depth of…
- Conditions
- Profound Muscle Relaxation, Muscle Trauma, Postoperative Analgesic Demand, Postoperative Pulmonary Function
- Trial name
- NCT01804933
- Testing
- profound neuromuscular blockade
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Ying Xiao
Hip Fractures
Analgesic Effect of Fascia Iliaca Compartment Block in Geriatric Patients With Hip Fracture
As population in Hong Kong is aging, incidence of geriatrics hip fractures rises. Operative treatment for selective patients offers pain control, early mobilization and reduction in medical morbidities and mortalities.
- Trial name
- NCT04478552
- Testing
- Fascia iliaca compartment block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- United Christian Hospital
Acute Pain, Postoperative Pain
Study of QL Analgesic Response and Extent
A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process.
- Conditions
- Acute Pain, Postoperative Pain, Regional Anesthesia Block
- Trial name
- SQUARE (NCT07566312)
- Testing
- Quadratus Lumborum with 1.5% Lidocaine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Long-bone Fractures
Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children
The main objective of this study is to evaluate the efficacy of two drugs: paracetamol and ibuprofen in association with morphine, compared with morphine alone on analgesia in children seen in the emergency department for a…
- Trial name
- MORPHAPAIN (NCT02477007)
- Testing
- Paracetamol, Ibuprofen, paracetamol + ibuprofen
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Remifentanil for General Anesthesia in Preeclamptics
The purpose of this study is to determine whether remifentanil use in preeclamptic patients may blunt hemodynamic response to intubation during general anesthesia for cesarean section.
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Pregnancy Complications
- Trial name
- NCT00567957
- Testing
- Remifentanil, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Gastric Cancer, Postoperative Pain
Comparison of the Postoperative Analgesic Effects of the Temperature-responsive Gel Mixed With Local Anesthetics Application and Ultrasound-guided Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Gastrectomy
This study is a single-center, prospective, randomized controlled trial designed to compare two established postoperative analgesic strategies in adult patients undergoing laparoscopic gastrectomy under general anesthesia.
- Trial name
- TAP-WELPASS (NCT07452471)
- Testing
- Ultrasound-guided Transversus Abdominis Plane (TAP) Block, Ropivacaine-Poloxamer 407 Hydrogel (Welpass®)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Gyeong-Jo Byeon, MD, PhD
Pain, Postoperative
the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.
Anterior cruciate ligament (ACL) injury is traumatic and debilitating and is typically repaired using an arthroscopic technique performed as an outpatient surgical procedure.
- Trial name
- NCT04020133
- Testing
- saphenous nerve block, popliteal plexus block, Plain bupivacaine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Fayoum University Hospital
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Frozen Shoulder, Depression
Non-adherence to Pain Medication Increases Risk of Postoperative Frozen Shoulder
Background: Postoperative Frozen-Shoulder (FS) or adhesive capsulitis is a relatively frequent complication (5-20%), even after simple arthroscopic shoulder surgeries.
- Trial name
- NaFS (NCT04758585)
- Testing
- Arthroscopy
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baden
Back Pain
Analgesic Efficacy of Intravenous Lidocaine for Postoperative Pain Following Adult Spine Surgery
The purpose of this study is to generate further insight into the role and effectiveness of the amide local anesthetic lidocaine as an adjuvant postoperative analgesic after adult spine surgery.
- Trial name
- NCT01043211
- Testing
- Lidocaine Hydrochoride Injection, without epinephrine, Normal Saline
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Impacted Mandibular Third Molar
Does Vitamin C Improve Postoperative Healing
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07012564
- Testing
- Vitamin C
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Pain
Observational Study of the Analgesic Effect of Treatment With rTMS in Patients With Chronic Neuropathic Pain
For ten years, rTMS, repetitive transcranial magnetic stimulation of the motor cortex, has found its place in the treatment of drug-resistant neuropathic pain.
- Trial name
- rTMSDOULNEURO (NCT02506699)
- Testing
- analgesic effect of rTMS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Carpal Tunnel Release
WALANT Technique (Wide Awake Local Anesthesia No Tourniquet) for Carpal Tunnel Release.
The carpal tunnel release (CTR) is now performed almost exclusively under regional anesthesia (RA) in France. RA requires the use of a pneumatic tourniquet to limit blood flow to the operated extremity and create a bloodless…
- Trial name
- WALA (NCT04494100)
- Testing
- TRONC, WALANT, Tourniquet
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- CMC Ambroise Paré
Analgesia, Anxiety
Analgesic and Anxiety Efficacy of Preemptive Pregabalin
Effective postoperative pain control after arthroscopic shoulder surgery optimizes postoperative rehabilitation, reduces anxiety, and can increase patient satisfaction and postoperative healing by providing amnesia and sedation.
- Conditions
- Analgesia, Anxiety, Arthroscopic Shoulder Surgery
- Trial name
- NCT04675671
- Testing
- Preoperative and postoperative anxiety measurement [Spielberger's State Anxiety Scale (STAI-S)] and [ Spielberg's State-Trait Anxiety Inventory (STAI-T) ]
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selcuk University
IUD Insertion Complication
Different Analgesics Prior to Intrauterine Device (IUD) Insertion: Is There Any Evidence?
Different ways of reducing pain during IUD insertion have been explored. So a randomized study will be conducted to test their role
- Trial name
- NCT02522130
- Testing
- Lidocaine, oral misoprostol, naproxen
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al Hayat National Hospital
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