Clinical trials: Analgesic
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Surgery, Thoracic
Comparing Erector Spinae Plane (ESP) and Thoracic Paravertebral (TPV) Block Analgesic Effect After Elective VATS
The aim of the study is to compare two different locoregional techniques in VATS.
- Trial name
- NCT05798585
- Testing
- ESP block
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Andrea Saporito
Pain
Effectiveness of Analgesia in Total Knee Arthroplasty
The purpose of this study is to compare the analgesic effectiveness of three techniques: the femoral nerve block, intraarticular infiltration or a combination of both in the control of pain in total knee arthroplasty (KA).
- Trial name
- ATR-2011 (NCT01304212)
- Testing
- several drugs: morphine chloride,ropivacaine,epinephrine,ketorolac, ropivacaine,morphine chloride,epinephrine,ketorolac, ropivacaine
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Jose Antonio Bernia Gil
Postoperative Pain, Lumbar Spine Surgery
Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery
This study aims to compare two different pain management methods in patients undergoing elective lumbar spine surgery. Patients are randomly assigned to receive either an ultrasound-guided erector spinae plane block (ESPB) or…
- Trial name
- SPINE-ANI (NCT07455565)
- Testing
- Erector Spinae Plane Block, Intravenous Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Akdeniz University Hospital
Pain
Chronic Lumbosacral Radiculopathy: Impact of an Analgesic Dietary Intervention on Pain & Function
The goal of this proposed research is to assess the preliminary efficacy of dietary interventions that change dietary fats in improving clinical outcomes related to lumbar radicular pain.
- Trial name
- LRPD (NCT02531711)
- Testing
- Diet A, Diet B
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of North Carolina, Chapel Hill
Labor Pain
Analgesic Efficacy of a Multiport Versus Uniport Flexible Catheter for Labor Epidural Analgesia
The purpose of this study is to determine whether multiple ports improve the analgesic efficacy of flexible catheters used for the provision of epidural analgesia during the entire continuum of labor and delivery
- Trial name
- NCT01861821
- Testing
- Multiport flexible catheter, Uniport flexible catheter
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Baylor Research Institute
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesics efficacy of paracetamol 1000mg vs 500mg . The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01082081
- Testing
- Paracetamol 1000 mg, Paracetamol 500 mg
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Postoperative Pain, Renal Transplantation
Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy
Background: Administration of morphine as boluses or via a patient controlled analgesic device (PCA) has been the standard practice for donors after nephrectomy.
- Conditions
- Postoperative Pain, Renal Transplantation, Morphine Adverse Reaction
- Trial name
- NCT04052867
- Testing
- Lignocaine, Normal saline
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Postoperative Pain
Efficacy of Adrenaline in Periarticular Analgesic Injection on Postoperative Pain Control After Total Knee Arthroplasty
Multimodal anesthetic drug injection has been used extensively and the results of many studies suggest that postoperative pain can relief and improve the postoperative satisfaction of patients.
- Trial name
- NCT03549221
- Testing
- 0.6 mg 1:1000 epinephrine (0.6 ml)
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Mahidol University
Post Abdominal Surgery Pain
A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdominal Surgery
The study schedule is comprised of a 14-day Screening Period, a treatment period and an observation period. All eligible subjects will be randomized into one of 3 treatment groups (1 of 2 dose levels or matched placebo).
- Trial name
- NCT02542384
- Testing
- CR845 IV 1 mcg/kg, CR845 IV 0.5 mcg/kg
- Where
- 23 sites in United States
- Volunteers
- 451 people
- Sponsor
- Cara Therapeutics, Inc.
Percutaneous Nephrolithotomy
The Effect of Anesthesia on Pain in Percutaneous Nephrolithotomy
It is aimed to determine the ideal application by determining the effect of different anesthesia methods applied in percutaneous nephrolithotomy surgeries on analgesic consumption and pain level.
- Trial name
- NCT05467878
- Testing
- The anesthesia and analgesia technique preferred by the anesthetist will be recorded.
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tugba Onur
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pain, Postoperative, Analgesia
Comparison of Postoperative Analgesic Efficacy of Caudal Block Versus Spinal Block With Levobupivacaine for Inguinal Hernia in Children
Neuraxial analgesia may improve postoperative outcomes for high-risk children who are susceptible to respiratory complications (e.g. post-operative apnea).
- Trial name
- NCT05117281
- Testing
- Levobupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pain, Postoperative
Postoperative Analgesic Effects of Infraorbital Nerve Block in Cleft Palate Surgery
Cleft palate repair is a common surgery in children.. As such children with cleft palate tend to have a compromised airway due to associated congenital anomalies like Pierre Robin syndrome, Treacher Collins syndrome etc.
- Trial name
- NCT04212611
- Testing
- INFRA ORBITAL BLOCK
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Hip Fractures
Obturator Nerve Block in Patients With Hip Fracture
About 10-30% of all patients with hip fracture have only insufficient analgesic effect of a femoral nerve block. One of the possible causes of this failure to provide analgesia from a single nerve block could be the that other…
- Trial name
- OPAD (NCT02408419)
- Testing
- Bupivacaine, Saline
- Where
- Denmark
- Sponsor
- University of Aarhus
Analgesic Quality, Mobility
Observational Study of Analgesia and Cost-efficiency of Analgetic Medication Pumps (Zalviso and PCA-syringe Pump (PCA=Patient Controlled Analgesia)) After Urogenital Intervention at the Clinical Daily Routine
The observational study will check if there is a difference in the postoperative care of patients with urogenital intervention while using the standard PCA-syringe pump or using the Zalviso sufentanyl sublingual analgetic system.
- Trial name
- NCT03355352
- Testing
- Sufentanil
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Nerve Block, Neuromuscular Blockade
LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty
LIA is the mainstay of postoperative analgesia in patients having knee arthroplasty. The combination of ACB-iPACK blocks has also been proposed as an effective analgesic modality for total knee arthroplasty.
- Trial name
- NCT04808947
- Testing
- Local infiltration analgesia, Ultrasound-guided adductor canal block
- Volunteers
- 60 people
- Sponsor
- Women's College Hospital
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Postoperative Pain
Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy
Renal cell carcinoma (RCC) accounts for 2-3% of all cancers and is a common malignancy of the genitourinary tract. Open nephrectomy, performed through midline, subcostal, or flank incisions, remains a standard treatment but often…
- Trial name
- NCT06892743
- Testing
- US-guided external oblique intercostal plane block (EOIPB)
- Where
- 2 sites in Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Analgesia, Obstetrical
Tenoxicam for Intrapartum Analgesia
The aim of this study is to assess whether tenoxicam is as effective as pethidine for analgesia during the first stage of labor.
- Trial name
- NCT02549118
- Testing
- Tenoxicam, Pethidine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
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