Clinical trials: Analgesic
Injection Site Haematoma, Local Anesthetic Toxicity
U/S Guided SAPB Versus Conventional IV Analgesics in Postoperative Pain Management in MRM
The aim of this study is to compare the effect of ultra-sound guided serratus anterior plane block versus conventional IV analgesics in postoperative pain management in modified radical mastectomy (MRM)
- Trial name
- SAPB (NCT05126394)
- Testing
- ultrasound guided serratus anterior plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hernia, Umbilical, Clonidine
Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty
This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery.
- Conditions
- Hernia, Umbilical, Clonidine, Pain, Postoperative, Ambulatory Surgical Procedures
- Trial name
- NCT07062497
- Testing
- Rectus Sheath Block, Rectus Sheath Block with Clonidine
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pain
Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery
Hypothesis: The intraoperative administration of ketamine will result in a 30% reduction in opiate requirement following endometrial ablation surgery and the intraoperative administration of ketamine will result in a decreased…
- Trial name
- NCT01106846
- Testing
- Group A: Saline Group, Group B: 1% Ketamine group
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Northwestern University
Nerve Block
Opioid-Free Pain Management After NUSS Surgery in Adolescents
The investigators applied ultrasound-guided bilateral transverse thoracic fascia block combined with intercostal nerve block-a previously unreported analgesic approach for post-thoracic surgery-to NUSS patients.
- Trial name
- NCT07288424
- Testing
- Nerve block
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Qin Zhang
Prostate Cancer
Evaluation of Post-operative Biochemical Recurrence in Patients Submitted to Radical Prostatectomy Under General Opioid-free Anesthesia Compared to Conventional General Anesthesia
The use of opioids facilitates angiogenesis and has a proven action in the immune system, mainly in the reduction of natural killer cell activity, favoring the migration of neoplastic cells and inhibiting humoral and cellular…
- Trial name
- NCT03212456
- Testing
- opioid-free group, Opioid Group, transversus abdominal plane block with ropivacaine
- Where
- Brazil
- Volunteers
- 146 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Acute Pain
Analgesic Efficacy of Magnesium Sulphate as an Adjuvant to Levobupivacaine in Erector Spinae Block for Acute Pain Management in Modified Radical Mastectomy
To evaluate the analgesic efficacy of magnesium sulphate as adjuvants to levobupivacaine in erector spinae plane block in modified radical mastectomy surgery for acute pain management
- Trial name
- NCT04732390
- Testing
- erector spinae block with bupivacaine, erector spinae block with bupivacaine and magnesium sulphate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- South Egypt Cancer Institute
Herpes Zoster, Mirogabalin
The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia.
- Conditions
- Herpes Zoster, Mirogabalin, Pain
- Trial name
- NCT07307170
- Testing
- Mirogabalin combined conventional therapy, Conventional therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative, Opioid Use
Erector Spinae Plane Blocks for Adolescent Idiopathic Scoliosis
Pediatric spinal fusion (PSF) surgery is a painful procedure that can treat adolescent idiopathic scoliosis (AIS). One technique that can potentially reduce patients' pain levels and need for opioid medication is the…
- Conditions
- Pain, Postoperative, Opioid Use, Recruitment
- Trial name
- NCT04500613
- Testing
- Bilateral Erector Spinae Plane Block with bupivacaine and dexamethasone, No bilateral Erector Spinae Plane Block (no bupivacaine and no dexamethasone)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
Opioid Use, Spine Fusion
Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion
In light of the current opioid epidemic, there is an urgent need to address chronic opioid use prior to surgery before it is exacerbated by postoperative surgical pain.
- Trial name
- NCT04095624
- Testing
- Spinal Fusion Preoperative Opioid Taper, Non-taper Control
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
General Anesthesia; Pediatric Surgery; Intraoperative Music Therapy; Operating Room Noise Reduction; Anesthetic Requirement; Analgesic Requirement
Effect of Intraoperative Instrumental Music and Operating Room Noise Reduction on Anesthetic and Analgesic Requirements in Pediatric Patients Aged 3-18 Years Undergoing Surgery Under General Anesthesia: A Randomized Controlled Trial
This randomized controlled clinical trial aims to evaluate the effects of intraoperative instrumental music and operating room noise reduction on anesthetic and analgesic requirements in pediatric patients aged 3-18 years…
- Trial name
- MUSIC-OR (NCT07630675)
- Volunteers
- 180 people
- Sponsor
- Ankara City Hospital Bilkent
Upper Limb Surgery, Iliac Crest Bone Harvest
Transversalis Fascial Plane Nerve Block in Iliac Crest Bone Graft
Hand or wrist surgery often requires the use of bony material in order to accomplish any associated reconstructive aspects required for the surgery.
- Trial name
- NCT01133730
- Testing
- Active treatment
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Transversalis Fascia Plane Block, Intrathecal Dexmedetomidine
Transversalis Fascia Plane Block Versus Intrathecal Dexmedetomidine in Patients Undergoing Cesarean Section
This study aims to compare the analgesic efficacy of the transversalis fascia plane (TFP) block and intrathecal dexmedetomidine in patients undergoing cesarean section (CS).
- Conditions
- Transversalis Fascia Plane Block, Intrathecal Dexmedetomidine, Cesarean Section
- Trial name
- NCT07170267
- Testing
- Transversalis fascia plane block, Intrathecal dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects
The purpose of the study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-experienced subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01675167
- Testing
- Buprenorphine
- Where
- 66 sites in United States
- Volunteers
- 815 people
- Sponsor
- BioDelivery Sciences International
Rheumatoid Arthritis
Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis
The purpose of this study is to evaluate the effectiveness of ADL5859 in relieving pain associated with rheumatoid arthritis (RA) compared with placebo and naproxen (similar to Aleve®).
- Trial name
- NCT00626275
- Testing
- ADL5859, Naproxen
- Where
- 8 sites in United States
- Volunteers
- 46 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Inguinal Hernia, Transversus Abdominis Plane (TAP) Block
Comparison of Postoperative Analgesic Efficacy of Ultrasound-Guided Ilioinguinal-Iliohypogastric Block, Transversus Abdominis Plane Block, and Quadratus Lumborum Block in Inguinal Hernia Surgery
Inguinal hernia is a common condition, particularly among male patients, and represents one of the most frequent indications for lower abdominal surgeries.
- Conditions
- Inguinal Hernia, Transversus Abdominis Plane (TAP) Block, Iliohypogastric/Ilioinguinal Nerve Block, Quadratus Lumborum Block
- Trial name
- NCT06997536
- Testing
- Ilioinguinal/iliohypogastric Nerve Block, Transversus abdominis plane (TAP) block, Quadratus Lumborum Block (QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Namik Kemal University
Narcotic Use, Postoperative Pain
A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries
There was a study titled "A prospective evaluation of opioid utilization after upper extremity surgical procedures: Identifying consumption patterns and determining prescribing guidelines" by Dr.
- Conditions
- Narcotic Use, Postoperative Pain, Narcotic Abuse, Opioid Use
- Trial name
- Opioids (NCT03422211)
- Testing
- Questionnaire
- Where
- 3 sites in United States
- Volunteers
- 223 people
- Sponsor
- St. Louis University
Pain, Postoperative, Arthroplasty, Replacement, Knee
Liposomal Bupivacaine in Total Knee Arthroplasty
Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives.
- Conditions
- Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
- Trial name
- NCT02426164
- Testing
- Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
- Where
- United States
- Sponsor
- Miller Orthopedic Specialists
Anesthesia
Comparison Between Two Ultrasound Technologies for Ultrasound-guided Catheter Placement in Regional Anesthesia
The use of ultrasound imaging techniques in regional anaesthesia is rapidly becoming an area of increasing interest. It represents one of the largest changes that the field of regional anaesthesia has seen.
- Trial name
- eZono (NCT01122693)
- Testing
- eZono - high-quality 2D ultrasound images, standard 2D ultrasound images
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- Charite University, Berlin, Germany
Pain
Local Infiltration Analgesia After Abdominal Hysterectomy
The aim of the study is to evaluate traditional analgesic therapy after abdominal hysterectomy with single infiltration of local anesthetics in the surgical area at the end of surgery.
- Trial name
- LIA (NCT01782781)
- Testing
- ropivacaine, ketorelac and epinephrine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
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