Clinical trials: Analgesic Effect
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain
Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery
Can perioperative administration of intra-peritoneal local anaesthetics further reduce postoperative pain, inflammation and outcome in patients undergoing major abdominal surgery (cytoreductive surgery) and managed with thoracic…
- Trial name
- IPLA (NCT02256228)
- Testing
- Ropivacaine, Saline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Pain
The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate…
- Trial name
- NCT01872494
- Testing
- local, intravenous, 0.33% ropivacaine 250ml
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Laparocele
Post-Operative Analgesic Effect of Tramadol and Nalbuphine in Smoker and Non-Smoker Patients in LC
This study aims to compare pain severity and analgesic requirements between smokers and nonsmokers following laparoscopic cholecystectomy, evaluating the efficacy of two analgesics, tramadol and nalbuphine.
- Trial name
- NCT07049380
- Testing
- Comparative cross sectional
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Superior University
Acute Pain, Analgesics
Monitoring Side Effects Of Pain Medication Prescribing By Emergency Department In Patients Over 65
Half of the people over the age of 65 are not functioning at their optimal level because of interference from pain. > 50% of older adults had taken prescriptions of pain medication beyond a 6-month period.
- Conditions
- Acute Pain, Analgesics, Elderly
- Trial name
- MOSE65 (NCT02046681)
- Where
- 5 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
To Assess the Beneficial Preemptive and Preventive Effects of PGL on the Immediate and Late (1- and 3 Months) Postoperative Analgesia Requirements
Pregabalin for Post-craniotomy Pain Control
Background: Proper pain relief is a major concern of patients worldwide. Preoperatively, one of the most common questions asked by patients pertains to the amount of pain they will experience after surgery how long it will last…
- Trial name
- NCT01612832
- Testing
- Pregabalin, Control
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Palatal Donor Site Wound Healing, Platelet Rich Fibrin
Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.
The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery.
- Conditions
- Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain
- Trial name
- NCT07637838
- Testing
- Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- 59th Medical Wing
Post Operative Pain
Analgesic Effect of M-TAPA and TAPB on Laparoscopic Cholesistectomy
Cholecystectomy is the most frequently performed abdominal surgery in developed nations, with laparoscopic cholecystectomy being recognized as the gold standard technique for treating gallstones.
- Trial name
- NCT06662617
- Testing
- modified thoracoabdominal nerve block through perichondrial approach, Transversus Abdominal Plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Inguinal Hernia, Postoperative Pain
Postoperative Effects of TAP Block Versus QLB Type 2 Block
This study compares analgesic effectiveness of transversus abdominis plane block and quadratus lumborum block type 2 in open hernia repair surgery. All of the patients will receive routine intravenous analgesic regimen.
- Trial name
- NCT03126084
- Testing
- Acetaminophen, 0.25% Bupivacaine, 0.5% Bupivacaine+Glucose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bozyaka Training and Research Hospital
Pain, Postoperative, Pain, Acute
Lidocaine and Magnesium and Ketamine in Gynecological Surgery
The aim of this study will be to investigate the effect of a combination of intravenous infusions of lidocaine and magnesium versus a combination of intravenous infusions of lidocaine and ketamine versus an intravenous infusion…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- annie-sophia (NCT04622904)
- Testing
- lidocaine-magnesium infusion, lidocaine-ketamine infusion, lidocaine infusion
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Aretaieion University Hospital
Post-traumatic Pain
Effect of Telemedecine on Post -Trauma Pain Medication Adherence .
The impact of telemonitoring on patients' adherence to post trauma pain treatment , their satisfaction and pain relief after discharge from the ED.
- Trial name
- NCT05149417
- Testing
- SMS reminding, telemonitoring
- Where
- 2 sites in Tunisia
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Knee Osteoarthritis
Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis
This randomized controlled trial aims to examine the effects of foot massage combined with cold application on postoperative pain, patient satisfaction, and analgesic consumption in individuals undergoing Total Knee Arthroplasty…
- Trial name
- NCT07126340
- Testing
- Foot Massage and Cold Application, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Vitrectomy
Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy
Traditional opioid analgesia is a method to treat moderate to severe pain. However, the use of opioids is not without risks. When treating acute pain, patients may have hypotension, respiratory depression, hypoxia, nausea and…
- Trial name
- NCT07097038
- Testing
- Oliceridine, Oxycodone
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Shoulder Arthroscopy, Postoperative Pain
Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy.
This study aims to evaluate whether adding magnesium sulfate to a combined costoclavicular and suprascapular nerve block improves postoperative pain control in patients undergoing shoulder arthroscopy.
- Conditions
- Shoulder Arthroscopy, Postoperative Pain, Regional Anesthesia
- Trial name
- CCSS-Mg (NCT07798115)
- Testing
- Bupivacaine, Magnesium sulfate (MgSO4), Normal Saline (NS)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Laparoscopic Gynecological Surgery
Analgesic Effect of Pulmonary Recruitment and Intraperitoneal Hydrocortisone in Laparoscopic Gynecological Surgery
The aim of this study is to compare the postoperative analgesic efficacy of intraperitoneal hydrocortisone to pulmonary recruitment maneuver in Laparoscopic gynaecological surgery.
- Trial name
- NCT03845608
- Testing
- Pulmonary Recruitment Maneuver
- Volunteers
- 45 people
- Sponsor
- Cairo University
Chronic Pain, Chronic Pain Syndrome
Deep Brain Therapy With Low-intensity Ultrasound for Generalized Chronic Pain
This study will evaluate a new form of non-invasive deep brain therapy for individuals with generalized chronic pain. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation…
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Widespread Chronic Pain
- Trial name
- DBT (NCT05674903)
- Testing
- Verum stimulation with Diadem prototype
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Utah
Hydrogen Peroxide Allergy
The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment.
Background: The administration of the intra-oral drugs was not capable of reducing this side effect, maybe the use of two analgesics may to present better analgesic effect to avoid the bleaching-induced tooth sensitivity (TS).
- Trial name
- NSAIDs (NCT03343392)
- Testing
- acetam/ketoro tromet group
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Hysterectomy
Comparative Study Between the Analgesic Effect of Dexmedetomidine and Magnesium Sulfate as Adjuvant to Bupivacaine Using Ultrasound-Guided Transversus Abdominis Plane Block in Abdominal Hysterectomy : A Randomized Double-blinded Study
Over 80% of patients who undergo surgery suffer from acute postoperative pain, with 75% of them rating the pain severity as moderate, severe, or extreme.
- Trial name
- NCT06720337
- Testing
- bupivacaine 0.5%, Dexmedetomidine, MgSO4
- Volunteers
- 64 people
- Sponsor
- Assiut University
OSTEOARTHRITIS OF THE KNEE
Analgesic Effects of a Treatment With Cannabis Sativa Extract in Patients With Knee Osteoarthritis - CANOA (Cannabis for Osteoarthritis)
Osteoarthritis (OA) is the most prevalent joint disease in humans, often causing disability in affected individuals, especially the elderly.
- Trial name
- NCT06588972
- Testing
- Medium Chain Triglyceride solution, Cannabis Sativa
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Federal University of Latin American Integration
Diabetic Peripheral Neuropathy
A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the effectiveness and safety of the investigational drug, tanezumab, in adult patients with painful diabetic peripheral neuropathy.
- Trial name
- NCT01087203
- Testing
- Tanezumab
- Where
- 48 sites in United States
- Volunteers
- 73 people
- Sponsor
- Pfizer