Clinical trials: Analgesic Effect
Pain
Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI
Paracetamol is one of the most widely used analgesic in the world, indicated for the symptomatic treatment of fever and pain. The objective of this study is to evaluate the mechanism of action of paracetamol (versus placebo) in…
- Trial name
- IRMf (NCT01562704)
- Testing
- Paracetamol (drug)
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Arthroscopy, Analgesia
Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
The aim of the study is to compare the diaphragmatic excursion and postoperative analgesia in the extrafascial versus intrafascial Interscalene brachial plexus block in patients undergoing shoulder arthroscopy.
- Conditions
- Arthroscopy, Analgesia, Intrafascial Interscalene Brachial Plexus Block
- Trial name
- NCT05222334
- Testing
- Intrafascial interscalene brachial plexus block, Extrafascial interscalene brachial plexus block group, Bupivacaine
- Volunteers
- 50 people
- Sponsor
- Tanta University
Pain, Postoperative, Ketamine Adverse Reaction
Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions
Evaluation of neuropsychiatric and cardiovascular side effects of low dose ketamine analgesic infusion for postoperative pain
- Trial name
- NCT03525912
- Testing
- Ketamine
- Where
- Colombia
- Volunteers
- 101 people
- Sponsor
- Universidad de Antioquia
Oliceridine, Postoperative Cardiac Surgery
1.Comparison of the Analgesic Effect of Remifentanil Group and Different Dose Groups of Oliceridine in Postoperative Patients Undergoing Cardiac Surgery 2.Exploring the Hemodynamic Effects of Analgesic Regimens With Different Doses of Oliceridine After Cardiac Surgery
Cardiac surgery has the characteristics of long duration and large amount of intraoperative bleeding, easy to involve multiple organs and severe tissue injury, which is one of the most serious surgical procedures with…
- Trial name
- NCT06619145
- Testing
- Low dose Oliceridine, High dose Oliceridine
- Where
- 2 sites in China
- Volunteers
- 270 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
ACL Repair, Meniscectomy
Efficacy Study of Continuous Intraarticular Infusion in Patients Undergoing Arthroscopic Knee and Shoulder Operations
The aim of this study is to determine whether the continuous intraarticular infusion of local anesthetics in the postoperative period can improve analgesia and patients satisfaction after knee and shoulder arthroscopy.
- Conditions
- ACL Repair, Meniscectomy, Bankart Repair
- Trial name
- NCT00314457
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Analgesia, Pain, Postoperative
Postoperative Analgesic Effects of Bilateral External Oblique Intercostal Block in Laparoscopic Cholecystectomy Surgery
The aim of our study is to reduce postoperative pain by performing external oblique intercostal block in L/S cholecystectomy surgeries. Our main goal is to provide well managed post-operative analgesia.
- Trial name
- NCT05444985
- Testing
- Pain Management
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun University
Colo-rectal Cancer
Does Omission of NSAIDs After Colorectal Cancer Operation Affect the Consumption of Opioids?
Patients undergoing an operation for colorectal cancer are normally treated with non-steroid-anti-inflammatory-drugs (NSAIDs) e.g. ibuprofen as pain medication after the operation.
- Trial name
- NCT04448652
- Testing
- NSAID
- Where
- Denmark
- Volunteers
- 502 people
- Sponsor
- Zealand University Hospital
Pain, Postoperative
Postoperative Analgesic Effects of Infraorbital Nerve Block in Cleft Palate Surgery
Cleft palate repair is a common surgery in children.. As such children with cleft palate tend to have a compromised airway due to associated congenital anomalies like Pierre Robin syndrome, Treacher Collins syndrome etc.
- Trial name
- NCT04212611
- Testing
- INFRA ORBITAL BLOCK
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Acute Pain, Wound Care
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the…
- Conditions
- Acute Pain, Wound Care, Posttraumatic Stress Disorder
- Trial name
- NCT03305055
- Testing
- ketamine, Fentanyl
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Cholecystectomy, Postoperative Pain
Analgesic Effect of Quadratus Lumborum Block Application After Laparoscopic Cholecystectomy Surgery
Laparoscopy is frequently used today for intraabdominal operations. Laparoscopic procedure has become the treatment of choice for many patients with symptomatic cholelithiasis.
- Conditions
- Cholecystectomy, Postoperative Pain, Nerve Block
- Trial name
- NCT03308955
- Testing
- Tramadol, Ultrasound guided Quadratus Lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Analgesia, Inguinal Surgery
"Comparison of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block for Pediatric Inguinal Surgeries"
This study is designed to compare the analgesic effectiveness of caudal analgesia to ilioinguinal regional analgesia techniques in children undergoing inguinal surgeries.
- Conditions
- Analgesia, Inguinal Surgery, Undescended Testes, Hydrocele
- Trial name
- CAUCIN (NCT05558748)
- Testing
- USG-guided Caudal block, USG-guided Ilioinguinal/Iliohypogastric block
- Where
- Oman
- Volunteers
- 128 people
- Sponsor
- Sultan Qaboos University
Abdominal Pain
The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision
Surgeons are the individuals who will operate on a patient if it is determined to be necessary after they present with abdominal pain.
- Trial name
- NCT00839787
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Gynecologic Disease
Opioid-free Anesthesia in Gynecologic Surgery
Post-operative nausea and vomiting (PONV) is common for the patients undergoing laparoscopic gynecologic surgery. PONV is a major factor for patient dissatisfaction, delayed patient recovery and increased medical expenses.
- Trial name
- NCT04700761
- Testing
- Opioid-free anesthesia, Opioid-using anesthesia
- Where
- South Korea
- Volunteers
- 164 people
- Sponsor
- Seoul National University Bundang Hospital
Opioid Free Anaesthesia, Opioid Anaesthesia
Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia.
The present study aims to assess the difference in postoperative opioid consumption between patients who intraoperatively receive a pecto-intercostal facial block combined with opioid-free anesthesia versus a traditional…
- Trial name
- NCT04854577
- Testing
- Opioid Free Anesthesia, Traditional Anesthetic Regimen
- Volunteers
- 64 people
- Sponsor
- Algemeen Stedelijk Ziekenhuis
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Spondylolisthesis, Facet Joint Hypertrophy
Caudal Block Versus Quadratus Lumborum Plane Block in Lumbar Surgery
Postoperative pain is a common complication after lumbar spine surgery due to inherent tissue damage during surgical procedures. Many analgesic options have been explored.
- Conditions
- Spondylolisthesis, Facet Joint Hypertrophy, Spinal Canal Stenosis
- Trial name
- NCT06398600
- Testing
- Caudal, Quadratus lumborum plane block
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Fayoum University Hospital
Hand Injuries
Analgesic Effects of Gabapentin and Paracetamol
This research is about the effects of drug gabapentin; which is an amino acid that is structurally similar to neurotransmitter GABA.
- Trial name
- GABA (NCT04068506)
- Testing
- Gabapentin 600 mg Tab
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Dow University of Health Sciences
Colorectal Cancer
Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block
Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.
- Trial name
- NCT03803267
- Testing
- Erector spinae plane block, Quadratus lumborum block, Propofol
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University
Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Transcranial Direct Current Stimulation of Opercular-insular Cortex
The aim of this study is to evaluate, versus placebo, the analgesic efficacy of the opercular-insular cortex stimulation with Transcranial Direct Current Stimulation (tDCS), in both healthy subjects and chronic neuropathic pain…
- Trial name
- STIM-INSULA (NCT03015558)
- Testing
- transcranial direct current stimulation of opercular-insular cortex - anodal active tDCS session, transcranial direct current stimulation of opercular-insular cortex - active control session
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon