Clinical trials: Analgesic Effect
Nociceptive Pain, Anesthesia
NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane
The purpose of this prospective randomized controlled study is to compare the analgesic properties of propofol and sevoflurane using variation of the NOL index and standard monitoring (Heart Rate and Mean Arterial Blood Pressure)…
- Trial name
- PROSEVNOL (NCT04567160)
- Testing
- Propofol, Sevoflurane
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Postoperative Pain
Quadratus Lumborum Block in Pediatric Patients
Quadratus lumborum block (QLB) is a newly-defined trunk block performed with local anesthetic injection by imaging the abdominal muscles with ultrasonography (US) guidance; thus, analgesia is expected to be ensured from the T7-L1…
- Trial name
- NCT03693222
- Testing
- Tramadol Hydrochloride, Morphine Sulfate
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
HIV Infections
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to gain initial information on the tolerability and feasibility of high-concentration capsaicin patches for the treatment of painful HIV-associated neuropathy, whether resulting from HIV disease and/or…
- Trial name
- NCT00061152
- Testing
- Capsaicin Dermal Patch
- Where
- 3 sites in United States
- Sponsor
- NeurogesX
Delirium, Postoperative Complications
Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection
Dexmedetomidine（DEX）is a potent and highly selective α 2 adrenergic receptor agonist. It has the pharmacological effects of sedation, hypnosis, analgesia, anti-sympathetic and neuroprotective.
- Conditions
- Delirium, Postoperative Complications, Pathologic Processes, Neurocognitive Disorders
- Trial name
- NCT03655847
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pain, Postoperative, Anxiety
Effect of VR on Anxiety and Pain in Gynecological Surgery
Rationale: Lack of postoperative acute pain management is associated with increased morbidity, longer recovery time, more opioid use and subsequently increased health care costs.
- Conditions
- Pain, Postoperative, Anxiety, Pain Catastrophizing, State Anxiety
- Trial name
- VRAP-G (NCT04687501)
- Testing
- Virtual Reality
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Zuyderland Medisch Centrum
Opioid-Related Disorders, Chronic Pain
Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Trial name
- 1401 (NCT02372591)
- Testing
- Buprenorphine, Hydromorphone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Hysterectomy, Postoperative Pain
Postoperative Analgesic Effectiveness of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach in Total Laparoscopic Hysterectomy
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total…
- Trial name
- MTAPA-TLH (NCT07740252)
- Testing
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Pain, Postoperative
The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy
Injection of intraperitoneal bupivacaine revealed an analgesic effect whether injected alone or in combination with other adjuvants, which increase duration of analgesia and decrease the dose of administered bupivacaine thus…
- Trial name
- RCTcompstud (NCT04244097)
- Testing
- Bupivacaine Hydrochloride, Neostigmine
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Pain, Cardiac Surgery
Parasternal vs. Combined Parasternal-Serratus Block in Cardiac Surgery
This randomized controlled trial aims to compare the analgesic efficacy of parasternal intercostal plane block (PIPB) alone versus the combination of parasternal intercostal plane block and serratus anterior plane block (SAPB) in…
- Trial name
- Hanedan Block (NCT07522229)
- Testing
- Parasternal Intercostal Plane Block, Parasternal Intercostal Plane Block + Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- BEDİA MİNE HANEDAN
Pain, Hyperalgesia
Analgesic Effect of Oxytocin Receptor Modulation
Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section.
- Conditions
- Pain, Hyperalgesia, Central Sensitization
- Trial name
- NCT01918475
- Testing
- Carbetocin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ceserean Section and Postoperative Pain
Analgesic Effect of Erector Spinae Plane Block After Caesarean Section
Background: Our hypothesis was that bilateral ESP block applied from the transverse process of T9 in women who underwent elective cesarean section with pfannenstiel incision under spinal anesthesia could provide effective…
- Trial name
- AnESPaCS (NCT04599842)
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Postoperative Analgesia, Transversus Abdominis Plane (TAP) Block
Transversalis Fascia Plane Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children
This prospective clinical study aims to compare the postoperative analgesic efficacy of the ultrasound-guided transversalis fascia plane block (TFPB) and the transversus abdominis plane (TAP) block in pediatric patients…
- Conditions
- Postoperative Analgesia, Transversus Abdominis Plane (TAP) Block, Transversalis Fascia Plane Block, Pediatric Surgical Procedures
- Trial name
- NCT07242196
- Testing
- Postoperative analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Closed Multiple Fractures of Upper and Lower Limbs
Is Analgesic Effect of Low Dose Ketamine-midazolam the Same as Morphine
the investigators assessed the effects of low-dose IV ketamine-midazolam versus morphine on pain control in trauma patients with closed limb fracture(s); and also compared the incidence of adverse events (mainly cardio pulmonary…
- Trial name
- NCT01807429
- Testing
- Ketamine-midazolam, Morphine
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Sacro Iliac Joint Pain, Low Back Pain
Analgesic Effect of Sacral Submultifidus Block as an Adjunct to Sacroiliac Joint Injection
The aim of this study is to assess whether the addition of sacral submultifidus block to standard image-guided SIJ injection provides superior analgesia and functional improvement compared with SIJ injection alone in patients…
- Conditions
- Sacro Iliac Joint Pain, Low Back Pain, Sacroiliatis
- Trial name
- NCT07814729
- Testing
- SIJ Injection Alone, receive SIJ Injection & Sacral Submultifidus Block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Fayoum University Hospital
Pain, Postoperative, Pulmonary Atelectasis
Paravertebral Block Versus Erector Spinae Plane Block for Modified Radical Mastectomy in Womens.
postoperative pain following Modified radical mastectomy is severe specially after dissection of tissues .paravertebral plane block provides an excellent postoperative analgesia for women's,but it carry the risk of pneumothorax…
- Conditions
- Pain, Postoperative, Pulmonary Atelectasis, Mastectomy
- Trial name
- NCT03614091
- Testing
- Erector spinae plane block, Paravertebral plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fibromyalgia
High-definition Transcranial Electrical Stimulation for Fibromyalgia
Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct current or alternating current to change the excitability of the cerebral cortex.
- Trial name
- NCT04550598
- Testing
- HD-tCES
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Taipei Medical University
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Temporomandibular Disorder
Analgesic Effects of LED Light on Temporomandibular Disorders.
Low intensity laser therapy (LILT) has been widely applied in pain relief in several clinical situations. With the advent of new LED-based (light emitting diode) light sources, the need of further clinical experiments aiming to…
- Trial name
- LED/TMD (NCT01873937)
- Testing
- Red LED, INFRARED LED, LASER
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pain, Postoperative, Postoperative Complications
Analgesic Effect of Morphine Added to Transverses Abdominis Plane Block
Postoperative pain is a condition that increases morbidity and mortality. Therefore, multimodal analgesia techniques with fascial plan blocks are frequently used.TAP block provides analgesia in the anterior abdominal wall by…
- Trial name
- NCT05420337
- Testing
- Group ıntramuscular, Group TAP
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Eskisehir Osmangazi University