Clinical trials: Analgesic Medication
Burns, Pain, Burning
Effects of Applying Streaming Media on Reducing Pain in Patient With Second-degree Burn During Changing Dressing
During the acute phase of burn injuries, the focus for patients is primarily on wound pain and infection care. Patients often describe the pain during dressing changes as a sharp, stabbing sensation.
- Conditions
- Burns, Pain, Burning, Anxiety
- Trial name
- NCT06076031
- Testing
- Streaming Media
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neuropathic Pain
Electroencephalographic (EEG) Profils for Patients on Intravenous Ketamine.
Chronic pain symptoms can lead to sleep and mood disorders, restrict domestic and work activities and have a significant impact on quality of life.
- Trial name
- KetEEG (NCT05949554)
- Testing
- Ketamine infusion
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain
Local Infiltration Analgesia After Abdominal Hysterectomy
The aim of the study is to evaluate traditional analgesic therapy after abdominal hysterectomy with single infiltration of local anesthetics in the surgical area at the end of surgery.
- Trial name
- LIA (NCT01782781)
- Testing
- ropivacaine, ketorelac and epinephrine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Analgesic Drugs, Antinociceptive Agents
Analgesic Effects of Midazolam in Human Volunteers
This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occasions (study visits) and the effect on…
- Trial name
- GabA01 (NCT02629146)
- Testing
- Midazolam, Fentanyl, Isotonic saline
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wilhelminenspital Vienna
High Dosage Buprenorphine
High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid
The prevalence of analgesics opioids addiction in chronic pain patient is very difficult to know. Many studies indicated that the prevalence of addiction varied from 0% up to 50% in chronic non cancer pain patients, and from 0%…
- Trial name
- SEVROP (NCT03156907)
- Testing
- Buprenorphine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Frozen Shoulder, Depression
Non-adherence to Pain Medication Increases Risk of Postoperative Frozen Shoulder
Background: Postoperative Frozen-Shoulder (FS) or adhesive capsulitis is a relatively frequent complication (5-20%), even after simple arthroscopic shoulder surgeries.
- Trial name
- NaFS (NCT04758585)
- Testing
- Arthroscopy
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baden
Paracervical Block
Paracervical Block During Office Hysteroscopy
The purpose of this study is to determine the effectiveness of paracervical block for pain relief in office hysteroscopy - particularly with the placement of the Essure device.
- Trial name
- NCT00811187
- Testing
- Lidocaine paracervical block, Normal Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Wound Care, Pain Intensity
Pain Medicine for Wound Care Procedures
This is a randomized double-blind study to determine if the administration of a small-dose of ketamine (an anesthetic)added to morphine (an opioid) contributes to reducing pain intensity during open wound care procedure (WCP)in…
- Conditions
- Wound Care, Pain Intensity, Hyperalgesia, Nausea
- Trial name
- NCT00701909
- Testing
- Morphine plus Ketamine
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Pain
Patient and Provider Confidence and Satisfaction With the Clinical Use of CYP Genetic Variability
This study utilizes the Medication DNA Insight™ tests for pain and mental health medications. We are testing the pain and mental health medications commonly used in pain treatment.
- Trial name
- Genomics (NCT02568618)
- Testing
- Pain Medication DNA Insight (TM) test
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Herpes Zoster, Neuralgia
NGX-4010 for the Treatment of Postherpetic Neuralgia
The purpose of the study is determine if an investigational drug, NGX-4010 (high-concentration capsaicin dermal patches) is effective in treating pain associated with post-herpetic neuralgia (PHN).
- Conditions
- Herpes Zoster, Neuralgia, Pain, Peripheral Nervous System Diseases
- Trial name
- NCT00061776
- Testing
- Capsaicin Dermal Patch
- Where
- 28 sites in United States
- Volunteers
- 300 people
- Sponsor
- NeurogesX
Herpes Zoster, Mirogabalin
The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia.
- Conditions
- Herpes Zoster, Mirogabalin, Pain
- Trial name
- NCT07307170
- Testing
- Mirogabalin combined conventional therapy, Conventional therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Herpes Zoster, Pain
The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia.
- Trial name
- NCT07378046
- Testing
- Baclofen combined conventional therapy, Conventional therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Delirium, Cognitive Dysfunction
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
- Trial name
- CODEX (NCT04289142)
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- 8 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neuralgia, Pain
Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain
The purpose of this study is to gain initial information on the tolerability of high-dose capsaicin patches in patients with Painful Postherpetic Neuralgia.
- Conditions
- Neuralgia, Pain, Peripheral Nervous System Diseases, Herpes Zoster
- Trial name
- NCT00034710
- Testing
- Capsaicin Patch
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- NeurogesX
Drug Interactions, Anesthesia, Conduction
Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery
Recently a new model for the interaction of sevoflurane propofol and remifentanil was developed. The potency of any combination of the three drugs is defined as probability that a subject tolerates laryngoscopy without movement…
- Trial name
- SPRV (NCT02457442)
- Testing
- Propofol and Remifentanil, Sevoflurane and Remifentanil, SPR 1
- Where
- Switzerland
- Volunteers
- 172 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Drugs, Investigational
Evaluate Analgesic Efficacy of Fast Release Aspirin
The objective of the study is to evaluate the analgesic efficacy of a single, oral dose of fast release aspirin tablets, 650 mg (2 x 325 mg) compared to regular aspirin tablets, 650 mg (2 x 325 mg) and placebo in subjects with…
- Trial name
- TAROT (NCT01122602)
- Testing
- Acetylsalicyclic acid (Fast acting Aspirin, BAY1019036), Acetylsalicyclic acid (Aspirin, BAYE4465)
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bayer
Steroid Anlgesia in Cancer Pain
Oral Prednisolone Effect on Cancer WHO Stepladder Analgesia Protocol
Introduction; World Health Organization (WHO) analgesic ladder; Step I recommends non-opioid analgesics for mild pain. Step II specifies the use of weak opioids for moderate pain.
- Trial name
- NCT04162379
- Testing
- Oral tablet
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Mansoura University
Analgesics, Opioid, Orthopedic Surgery
A Patient Education Video Program for Post-Operative Recovery After Upper Extremity Surgery
Adult patients undergoing elective outpatient, upper extremity, orthopedic surgeries will be randomized to view one of two educational programs: 1) a 2-video series regarding post-operative pain management or 2) a video regarding…
- Conditions
- Analgesics, Opioid, Orthopedic Surgery, Ambulatory Surgery, Education, Patient
- Trial name
- NCT03366805
- Testing
- Pain Management Patient Education Video, Wound Care Patient Education Video
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Carilion Clinic