Clinical trials: Analgesic Medication
Analgesia
Postoperative Analgesia After Shoulder Replacement
A comparison was made regarding opioid analgesic usage immediately after elective shoulder replacement and for seven days at home between patients randomly given either 0.5% or 0.75% ropivacaine via interscalene block prior to…
- Trial name
- NCT01003860
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Chronic Pain
Predicting Oxycodone Dose From Oral Fluid Drug Levels
This study will develop and test an algorithm that will estimate drug dosage from drug levels measured in oral fluid (saliva). Traditionally, urine has been used as the principle medium to monitor drug compliance in patients…
- Trial name
- AFTSLabs (NCT01928303)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Weill Medical College of Cornell University
Substance-Related Disorders
Abuse Liability of Controlled-Release Oxycodone Formulations
The objective of this study is to examine the abuse liability of a single 40mg dose of 2 controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent recreational opioid users by assessing the…
- Trial name
- NCT02101840
- Testing
- Apo-Oxycodone CR®, OxyNEO®
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Chronic Pain
Evaluation of an Opioid Decrease Strategy in Chronic
Increase in the consumption of analgesics observed in many countries with a mediatic crisis resulting in an increasingly frequent wish of patients to wean themselves from opiates. A recent update (B.
- Trial name
- EODSCPP (NCT04424459)
- Testing
- opioid withdrawal
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Nerve Block; Pain Medication
Obturator Nerve Block With Femoral and Sciatic Block
The purpose of this study is to evaluate how many patients require the addition of the obturator nerve block in the recovery room after the total knee surgery.
- Trial name
- NCT01409460
- Testing
- Oburator Nerve block
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Trinity Health Of New England
Opioid-Related Disorders, Opiate Addiction
Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic Pain
The purpose of this study is to evaluate the effect on pain intensity (PI) of structured discontinuation of long-term opioid analgesic therapy compared to continuation of opioid therapy in Suboptimal and Optimal Responders to…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02741076
- Testing
- Structured discontinuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER), Continuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER)
- Where
- 61 sites in United States
- Volunteers
- 44 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
Developing a Method to Objectively Measure Opioid Analgesia
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and…
- Trial name
- NCT03605966
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Julia Finkel
Chronic Pain
Difficult Encounters in Pain Medicine
The investigators are seeking to determine factors associated with difficult patient encounters in an academic pain clinic. The investigators are examining 36 different variables to determine the association with "difficult"…
- Trial name
- NCT05585619
- Testing
- Pain treatment
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Johns Hopkins University
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Constipation, Bowel Dysfunction
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
A multicenter study to evaluate the effectiveness and safety of multiple dosage regimens of an investigational drug for the treatment of constipation due to prescription pain medication in subjects with cancer pain.
- Trial name
- NCT00101998
- Testing
- alvimopan
- Where
- 162 sites in United States, Argentina and 24 more
- Volunteers
- 233 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain, Postoperative, Postoperative Complications
Methadone in Cystectomy Patients
The role of a single-dose intraoperative methadone on postoperative pain and opioid consumption in patients undergoing Surgeon Accuracy Robot Assistant cystectomy.
- Conditions
- Pain, Postoperative, Postoperative Complications, Pathologic Processes, Bladder Cancer
- Trial name
- METAMORF (NCT04475029)
- Testing
- Methadone, Morphine
- Where
- Denmark
- Volunteers
- 114 people
- Sponsor
- University of Aarhus
Pain
Effect of Topical Nepafenac 0.1% on Pain Related to Intravitreal Injections
The analgesic effect of Nepafenac 0.1% Ophthalmic Drops on ocular pain related to intravitreal injections will be evaluated. Pain perception will be assessed by the Short Form of the McGill Pain Questionnaire.
- Trial name
- NCT02821390
- Testing
- Nepafenac Eye Drops
- Where
- Greece
- Volunteers
- 55 people
- Sponsor
- University Hospital of Patras
Postoperative Pain
Analgesic Efficacy of Sequential Rapid Versus Slow Intrathecal Injection Of Dexmedetomidine Followed by of Hyperbaric Bupivacaine in Inguinal Hernia Repair Surgery
Analgesic Efficacy of Sequential Rapid Intrathecal Injection Of Dexmedetomidine Followed by Slow Injection of Hyperbaric Bupivacaine Versus Sequential Slow Injection of Both Drugs in Patients Undergoing Unilateral Inguinal Hernia…
- Trial name
- NCT06253260
- Testing
- Analgesic Efficacy of Sequential Rapid Intrathecal Injection Of Dexmedetomidine Followed by Slow Injection of Hyperbaric Bupivacaine Injection in Patients Undergoing Unilateral Inguinal Hernia Repair, Analgesic Efficacy of Sequential Slow Intrathecal Injection Of Dexmedetomidine Followed by Slow Injection of Hyperbaric Bupivacaine in Patients Undergoing Unilateral Inguinal Hernia Repair Surgery
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Ambulatory Hand Surgery
Patient Education and Use of Post Operative Pain Medication in Ambulatory Hand Surgery: a Randomized Controlled Trial
There is a current opioid epidemic in the United States partially fueled by excess prescribing practices after surgery. The objective of this study is to decrease the amount of opioids needed after ambulatory hand surgery.
- Trial name
- NCT03219177
- Testing
- Patient education regarding indications for opioid use and side effects of opioid use after hand surgery, Standard of care post-operative counseling
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Arthritis
Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the long-term analgesic efficacy and safety of tanezumab for patients with osteoarthritis (OA) of the knee or hip currently experiencing partial benefit from, and are tolerating…
- Trial name
- NCT00809354
- Testing
- NSAID, tanezumab
- Where
- 333 sites in United States, Canada and 10 more
- Volunteers
- 2,720 people
- Sponsor
- Pfizer
Undesired Pregnancy
Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)
The main objective of this study is to determine the equivalency of oral conscious sedation and intravenous conscious sedation for first trimester surgical abortion.
- Trial name
- NCT00337792
- Testing
- oxycodone + lorazepam versus fentanyl + midazolam
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Abdominal Pain
The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision
Surgeons are the individuals who will operate on a patient if it is determined to be necessary after they present with abdominal pain.
- Trial name
- NCT00839787
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Astrocytoma, Grade IV, Giant Cell Glioblastoma
Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM
This study will find the maximum safe dose (MSD) or maximum tolerated dose (MTD) of CYNK-001 which are NK cells derived from human placental CD34+ cells and culture-expanded.
- Conditions
- Astrocytoma, Grade IV, Giant Cell Glioblastoma, Glioblastoma Multiforme, Cyclophosphamide
- Trial name
- CYNK001GBM01 (NCT04489420)
- Testing
- CYNK001-IV, CYNK001-IT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Celularity Incorporated
Opiate Dependent, Previous Illicit Drug Use
Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine
The purpose is to study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone/buprenorphine in opiate-dependent patients…
- Trial name
- PUPIDOL (NCT01560442)
- Testing
- Buprenorphine and Methadone Hydrochloride
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Depression, Major Depressive Disorder
Nitrous Oxide for the Treatment of Major Depressive Disorder
The investigators are conducting a randomized controlled trial to evaluate the antidepressant effects of nitrous oxide in people with Major Depressive Disorder (MDD).
- Trial name
- NCT03869736
- Testing
- Nitrous Oxide
- Where
- 2 sites in United States, Australia
- Volunteers
- 81 people
- Sponsor
- Bayside Health