Clinical trials: Analgesic Overuse Headache
Chronic Migraine, Medication Overuse Headache
Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of non-invasive brain stimulation as an add-on treatment to standard detoxification therapy in patients with chronic migraine and…
- Trial name
- NCT07442916
- Testing
- Active rTMS Motor Cortex Face, Active rTMS - Motor Cortex Forearm
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Medication Overuse Headache
Medication Overuse Headache (MOH) and an Innovative Approach
Appropriate delivery of quality healthcare requires constant monitoring of the patient during follow up, particularly in the presence of chronic diseases.
- Trial name
- COMOESTAS (NCT02435056)
- Testing
- IEPR Approach
- Volunteers
- 690 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Medication Overuse Headache
Medication-overuse Headache: 4 Years Follow up
From 1 January 2004 to 31 December 2006 64 individuals with probable medication overuse headache were included in a randomized, 1-year open-labeled, multicentre study to evaluate the effect of early introduction of prophylactic…
- Trial name
- MOHfollowup (NCT00918671)
- Testing
- No new specific intervention
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Medication Overuse Headache
Pilot Study of DFN-11 Injection in Medication Overuse Headache
Efficacy and Safety Pilot Study of DFN-11 Injection in Medication Overuse Headache
- Trial name
- NCT02583425
- Testing
- DFN-11 Injection
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Migraine, Medication Overuse Headache
A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache
Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat a headache or migraine once it begins).
- Trial name
- RESOLUTION (NCT05452239)
- Testing
- Eptinezumab
- Where
- 76 sites in United States, Australia and 9 more
- Volunteers
- 608 people
- Sponsor
- H. Lundbeck A/S
Episodic Migraine, Chronic Migraine
i-NEED: NEw migrainE Drugs Database
Approved by the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) starting in 2018, anti-CGRP monoclonal antibodies (anti-CGRP mAbs) represent the first true revolution in the preventive treatment of…
- Conditions
- Episodic Migraine, Chronic Migraine, Medication Overuse Headache
- Trial name
- i-NEED (NCT07103694)
- Testing
- anti-CGRP monoclonal antibodies, gepants, combination of sumatriptan and naproxen
- Where
- 2 sites in Italy
- Volunteers
- 2,641 people
- Sponsor
- IRCCS San Raffaele Roma
Migraine, Migraine With Aura
Gepant treAtments: EffectIveNess and tolERability (GAINER)
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as acute migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- GAINER (NCT05903027)
- Testing
- Rimegepant 75 MG Disintegrating Oral Tablet
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Medication Overuse Headache
CBT in Patients With Medication Overuse Headache
According to the definition from International Headache Society, medication overuse headache (MOH) is diagnosed when patients takes painkillers for more than 10 or 15 days per month (depending on what kind of painkillers being…
- Trial name
- NCT01754571
- Testing
- Cognitive behavior therapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Medication Overuse Headache
Ibudilast in the Treatment of Medication Overuse Headache
The purpose of this study is to determine if ibudilast is effective in reverting patients with medication overuse headache suffering chronic daily headache back to their original episodic headache pattern.
- Trial name
- NCT01317992
- Testing
- Ibudilast
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- University of Adelaide
Medication-overuse Headache, Treatment
Treatment Response in Patients With Medication-Overuse Headache
The aim of this study to evaluate pre-injection patient-related factors that may influence treatment response in patients with medication-overuse headache who underwent ultrasound-guided greater occipital nerve block.
- Conditions
- Medication-overuse Headache, Treatment, Headache, Greater Occipital Nerve Block
- Trial name
- NCT07487649
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan 1. Murat State Hospital
Migraine, Migraine With Aura
Effectiveness and Tolerability of Eptinezumab
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of eptinezumab as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- TACHIS (NCT06409845)
- Testing
- Eptinezumab 100 or 300 mg ev
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- University of Florence
Migraine Disorders, Medication-overuse Headache
Longitudinal Study of the Patients With Medication-overuse Headache or Migraine That Completed Baseline MRI
This is a phone interview research study for patients with migraine or medication-overuse headache (MOH) who have completed baseline MRI scans.
- Trial name
- LMMM (NCT05528081)
- Testing
- Phone interview
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Wei Dai
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Chronic Migraine, Behavioral Treatment
Biofeedback-VR for Treatment of Chronic Migraine
Migraine is a common, debilitating neurologic condition affecting more than 900 million individuals worldwide. Established treatments for migraine include medications, vitamin and herbal supplements, neuromodulation, and…
- Conditions
- Chronic Migraine, Behavioral Treatment, Biofeedback, Virtual Reality
- Trial name
- NCT05720819
- Testing
- Combined biofeedback-virtual reality device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Medication Overuse Headache, Analgesic Overuse Headache
Frovatriptan as a Transitional Therapy in Medication Overuse Headache
This study will analyze the effectiveness of a medication called Frovatriptan, in the context of medication overuse headache (MOH). MOH is a headache that develops when pain-killers are taken frequently.
- Trial name
- NCT01044251
- Testing
- Frovatriptan
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of Calgary
Medication Overuse Headache, Chronic Migraine, Headache
Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches
Purpose: In this study, the investigators compared the effectiveness of peripheral nerve block (greater occipital nerve block with supratrochlear nerve block) versus topiramate as detoxification therapies in chronic migraine…
- Trial name
- NCT03767062
- Testing
- Topamax, Greater Occipital Nerve Block + Supratrochlear Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Chronic Migraine, Medication Overuse Headache
Anodal tDCS in Chronic Migraine With Medication Overuse
Non-invasive neuromodulation has been applied in several forms of primary headaches, and its usefulness has been suggested for both episodic and chronic migraine (CM).
- Trial name
- NCT04336267
- Testing
- Transcranial direct current stimulation (tDCS) group
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine, Medication Overuse Headache
Eptinezumab in Adults With Migraine and Medication Overuse Headache
This study evaluates the efficacy of eptinezumab to prevent migraine and headache in patients with the combined diagnosis of migraine and medication overuse headache
- Trial name
- Sunlight (NCT04772742)
- Testing
- Eptinezumab
- Where
- 40 sites in China, Georgia and 3 more
- Volunteers
- 193 people
- Sponsor
- H. Lundbeck A/S
Medication Overuse Headache
Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache
This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF).
- Trial name
- PRIMOGON (NCT07360782)
- Testing
- Greater Occipital Nerve Pulsed Radiofrequency, Standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Headache Disorders, Primary, Migraine
China HeadAche DIsorders RegiStry
It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected.
- Conditions
- Headache Disorders, Primary, Migraine, New Daily Persistent Headache, Medication Overuse Headache
- Trial name
- CHAIRS (NCT05334927)
- Testing
- Medicine Overuse Headache/New Daily Persistent Headache, Episodic Migraine and Chronic Migraine, Patients with other types of primary headache
- Where
- 61 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital