Clinical trials: Analgesics
Frequent Episodic Tension-Type Headache
Treatment of Tension-type Headache by Zhixuan Analgesic Tablets
The goal of this clinical trial is to learn if Zhixuan Analgesic Tablet works to treat frequent episodic tension-type headache in adults aged 18-60 years. It will also learn about the safety of Zhixuan Analgesic Tablet.
- Trial name
- NCT07872943
- Testing
- Zhixuan Analgesic Tablet
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Tongji Hospital
Non-specific Low Back Pain (NSLBP), Facet Joint Syndrome
Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain
Chronic musculoskeletal pain of non-specific origin affects approximately 30% of the global population. Beyond its prevalence, it represents a serious health and socioeconomic problem.
- Trial name
- PENSAR (NCT07273006)
- Testing
- Nerve block with Lidocain, Percutaneous electrical nerve stimulation
- Where
- Poland
- Volunteers
- 82 people
- Sponsor
- Universidad Complutense de Madrid
Pain
Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries
We compared the pain relief of acetaminophen with codeine versus ibuprofen for children ages 5-18 years who came to the Pediatric Emergency Department with injuries to their arms or legs.
- Trial name
- NCT00474721
- Testing
- ibuprofen, acetaminophen with codeine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Diego
Breast Cancer Female, Pain, Postoperative
Analgesic Effect of Adding Thoracic Paravertebral Nerve Blocks to Modified PEC Block in Breast Cancer Surgery
To compare efficacy and safety of adding thoracic paravertebral nerve blocks to modified PEC block versus modified PEC block only in breast cancer surgery.
- Trial name
- NCT04056676
- Testing
- Thoracic paravertebral block under ultrasound guidance, Intraoperative modified PEC block, GA with ETT
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Healthy Volunteers
Analgesic Tolerance to Repeated Doses of Subcutaneous Morphine
30 healthy volunteers will be enrolled in this 6-session study. The first visit will be a screening/orientation session. The next 5 visits will be (full day) outpatient sessions taking place Monday through Friday during one week.
- Trial name
- NCT00256347
- Testing
- intramuscular injections of morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain, Postoperative, Anesthesia, Local
Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Aim The general aim of this study is to improve post-operative pain and reduce morphine consumption following laparoscopic ventral hernia repair (LVHR).
- Conditions
- Pain, Postoperative, Anesthesia, Local, Hernia, Ventral, Laparoscopy
- Trial name
- NCT02785276
- Testing
- AutoFuser Pain Pump, Ropivacaine, Normal Saline (0.9%)
- Where
- New Zealand
- Sponsor
- University of Auckland, New Zealand
Low Back Pain
A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain
To compare the analgesic effectiveness of celecoxib and tramadol in subjects with Chronic Low Back Pain measured by the Numerical Rating Scale (NRS-Pain) at Week 6
- Trial name
- NCT00662558
- Testing
- celecoxib, tramadol HCL
- Where
- 60 sites in United States
- Volunteers
- 802 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Anesthesia
Comparison of Analgesic Effect of Volatile Anesthetics
The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.
- Trial name
- NCT02830243
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kangbuk Samsung Hospital
Pacemaker Implantation, Pain
Effect of Local Anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) Cream and Reduction in Dose, Pain and Intravenous Analgesic During Permanent Pacemaker Implantation
The investigators believe that the local anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) cream will lessen pain and reduce the need for anesthesia and analgesia, when implanting a permanent pacemaker.
- Trial name
- NCT02016976
- Testing
- EMLA Analgesic Cream, Dormicum 2.5 mg and Pethidine 25 mg
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hillel Yaffe Medical Center
Pain, Postoperative
Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children
Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children
- Trial name
- NCT04049838
- Testing
- postoperative analgesia for lower abdominal surgery in children
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Kasr El Aini Hospital
Pain, Postoperative
Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
The objective of the study is to evaluate the efficacy and safety of a single oral dose of naproxen sodium 440 mg in combination with DPH (diphenhydramine) 25 mg in subjects with postsurgical dental pain and phase advanced sleep.
- Trial name
- Morpheus/DPH (NCT01495858)
- Testing
- Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111), Naproxen Sodium 440 mg (BAYH6689), DPH 50 mg
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Pain
Immune Response of Caudally Administrated Tramadol In Pediatric Lower Abdominal Surgery
Management of acute pain is one of the most important tasks of perioperative pediatric anesthesia. The alleviation of pain has been defined by the Society of Pediatric Anesthesia, on its 15th annual meeting as a basic human…
- Trial name
- NCT02703415
- Testing
- Bupivacaine, Tramadol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Drug-Resistant Epilepsy, Epilepsy
Ultrasound-Guided Intermediate Cervical Plexus Block for Postoperative Analgesia in Vagus Nerve Stimulation Surgery
This retrospective cohort study evaluated the medical records of adult patients who underwent vagus nerve stimulator (VNS) implantation under general anesthesia for drug-resistant epilepsy at Fırat University Hospital between…
- Conditions
- Drug-Resistant Epilepsy, Epilepsy, Postoperative Pain
- Trial name
- NCT07689617
- Testing
- Ultrasound-guided intermediate cervical plexus block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Firat University
Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block
Comparison of Postoperative Analgesic Efficacy of Transversus Abdominis Plane Block (TAP) and Modified Thoracoabdominal Nerve Block (M-TAPA)
Laparoscopic cholecystectomy is a frequently performed surgical procedure and is considered the gold standard for treating symptomatic gallstone disease.
- Conditions
- Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Trial name
- NCT06932835
- Testing
- Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Post-craniotomy Pain Management, Post-craniotomy
Comparison of Pain Using CPOT Score With Ketamine vs. Dexmedetomidine in Post-Craniotomy ICU Patients
Study Overview: This study is designed to compare two different medications used to manage pain after craniotomy surgery in the ICU.
- Conditions
- Post-craniotomy Pain Management, Post-craniotomy, Pain Control in ICU, Ketamine vs Dexmedetomidine for Pain Relief
- Trial name
- CPOT-KD (NCT07254936)
- Testing
- ketamine, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sumatera Utara
Craniomandibular Disorders
Analgesic Effect of Cathodal tDCS Over Right DLPFC in Subjects With Muscular TMD: a Double Blind Crossover RCT
1. BACKGROUND: Temporomandibular Disorders (TMD) have become part of the daily routine of all the health care professionals. Some studies have shown improvement in subjects with chronic pain using neuromodulation.
- Trial name
- NCT02152267
- Testing
- tDCS
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Federal University of Bahia
Post Operative Pain
Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
The purpose of this study is to compare, the safety, efficacy and level of parent and nurse satisfaction with three methods of opioid administration post-operatively in children (4-18 years of age) with developmental delay.
- Trial name
- PNCA (NCT00743730)
- Testing
- Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical College of Wisconsin
Low Back Pain, Mechanical
Effectiveness of Chiropractic Application for Acute Low Back Pain
The aim of this project is to investigate the effectiveness of chiropractic application on patients who have undergone routine medication as a standard hospital treatment for mechanical low-back pain as described in the Clinical…
- Trial name
- NCT04110119
- Testing
- diclophenac sodium (75 mg, IM) and thiocolchicoside (4 mg, IM), Chiropractic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Medipol University
Painless Labor, Epidural Analgesia
The Post Cesarean Section Analgesic Effect of Various Quadratus Lumborum Block Approaches
included patients were divided into 4 groups and each group received a mode of post cesarian section analgesia and pain was assessed by visual analogue scale at rest and movement. 1. st group epidural analgesia 2.
- Conditions
- Painless Labor, Epidural Analgesia, Cesarean Section
- Trial name
- NCT06393192
- Testing
- Epidural analgesia (EA) only group, Quadratus lumborum block (QL2), Quadratus lumborum block 3(QL3)
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Opioid Use, Unspecified
Effect of Opioid Shortage on Drug Selection
This study will look at the effects of fentanyl shortage in laparoscopic cholecystectomy cases. The opioid shortage, specifically hydromorphone and fentanyl, caused a decrease in administration of opioid analgesia for…
- Trial name
- NCT04099030
- Where
- United States
- Volunteers
- 1,668 people
- Sponsor
- Wake Forest University Health Sciences