Clinical trials: Anaphylaxis
Neuromuscular Blocking Agents Anaphylaxis
Allergy to Neuromuscular Blocking Agents and Pholcodine Exposure
The main objective of this study is to compare pholcodine exposure in patients having presented with a perianaesthetic anaphylactic reaction to a NMBA (cases) to pholcodine exposure in matched anaesthetised patients with…
- Trial name
- ALPHO (NCT02250729)
- Testing
- intradermal pholcodine allergy test in cases, Blood sampling
- Where
- 24 sites in France
- Volunteers
- 1,020 people
- Sponsor
- Central Hospital, Nancy, France
Food Allergy, Food Allergy Peanut
Preventing Anaphylaxis With Acalabrutinib
Food allergy is a potentially life-threatening condition, and its prevalence continues to increase despite public health efforts. There are currently no known therapies that can reliably prevent food-induced anaphylaxis.
- Trial name
- NCT05038904
- Testing
- Acalabrutinib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Health Literacy, Anaphylaxis
Health Literacy Among Caregivers of Children With IgE-mediated Allergy With Risk of Anaphylaxis
Research on health literacy among caregivers of children with IgE-mediated allergy at risk of anaphylaxis (life-threatening allergic reaction).
- Trial name
- NCT04475003
- Testing
- Teaching
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Immune Deficiency, Immune Dysregulation Disorder
Allergy and Immunology Natural History Study
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation.
- Conditions
- Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation
- Trial name
- NCT05584488
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Peanut Allergic Subjects
Peanut Oral Immunotherapy in Children With Peanut Allergy (Peanut Flour)
Many children who are allergic to peanuts do not outgrow their allergy and have very severe allergic reactions called anaphylaxis.
- Trial name
- PeanutFlour (NCT02203799)
- Testing
- Peanut Oral Immunotherapy (POIT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Anaphylaxis Food
Predicting Peanut Anaphylaxis and Reducing Epinephrine
This research study is testing a new way to look for the early stages of anaphylaxis. Eligible participants will have a small monitor (transepidermal water loss) placed on the forearm during a food challenge (for peanut…
- Trial name
- PrePARE (NCT05696236)
- Testing
- Transepidermal water loss (TEWL) monitor and stopping rules, Monitor (TEWL) without stopping rules
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Anaphylaxis
Bioavailability of Nasal Epinephrine
A Study to Compare the Bioavailability of Epinephrine following a Single Nasal Dose of FMXIN002 Microspheres Powder with Epinephrine 0.3 mg Intramuscular Injection in Adult Subjects with Seasonal Allergic Rhinitis with and…
- Trial name
- NCT04696822
- Testing
- Epinephrine Nasal Product, 1.6 mg, Epinephrine nasal product, 1.6 mg + allergen, Epinephrine Injection 0.3 mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Status Epilepticus, Anaphylaxis
Smartphone Apps for Pediatric Resuscitation
Medication errors are common in children. Characteristics of errors during critical situations in the Emergency Department are ill-defined and might be more frequent than previously thought.
- Trial name
- SMARTER (NCT02958605)
- Testing
- Smartphone apps, Handbook
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Pompe Disease
Alglucosidase Alfa Pompe Safety Sub-Registry
To collect uniform and meaningful data on patients with Pompe disease who experience anaphylaxis, severe allergic reactions, and/or signals of severe cutaneous and/or systemic immune complex-mediated reactions following treatment…
- Trial name
- NCT01710813
- Testing
- alglucosidase alfa
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 110 people
- Sponsor
- Genzyme, a Sanofi Company
Ant Sting, Immunotherapy
Study of Sting Challenge and Serological Responses to Jack Jumper Venom Immunotherapy With Inulin as Adjuvant (Jumpvax)
The purpose of this study is to assess the potential use of delta-inulin as an adjuvant to facilitate the desired immune response to Jack Jumper Ant (JJA) venom with a lower dose of venom, thus reducing adverse reactions, venom…
- Trial name
- Jumpvax (NCT03066986)
- Testing
- Delta-inulin, Dose finding comparison
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Severe Anaphylactic Reaction, Self-administration, Adrenaline, Self-assessment
Relevance of the Self-assessment of Skills for Self-administration of Adrenaline by Auto-injectors in Patients at Risk of Severe Anaphylactic Reaction (PacAdré)
To investigate the correlation between self-assessment by patients and an assessment by a health professional of the skills needed for self administration of adrenaline by auto-injectors.
- Trial name
- PacAdré (NCT05404165)
- Volunteers
- 56 people
- Sponsor
- University Hospital, Grenoble
Food Hypersensitivity, Anaphylaxis
A Study About the Use of Omalizumab in the Treatment of Food Allergy and Anaphylaxis
This was a retrospective, multi-center observational study conducted across four allergy departments in Europe (Berlin, Leipzig, Barcelona, and Basel).
- Trial name
- NCT07027163
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Food Hypersensitivity, Immune System Diseases
Oral Immunotherapy in Food Allergy in Finland
The outcomes of oral immunotherapy (OIT) in food allergy study will provide more knowledge of oral immunotherapy. So far the OIT has showed in clinical experiments to be a interesting way to increase the unresponsiveness in…
- Conditions
- Food Hypersensitivity, Immune System Diseases, Anaphylaxis
- Trial name
- NCT02640014
- Testing
- Milk
- Where
- Finland
- Volunteers
- 250 people
- Sponsor
- Helsinki University Central Hospital
Anaphylaxis
Epidemiology and Outcome of Anaphylactic Shocks Admitted to Intensive Care Unit
Anaphylaxis is a severe life-threatening reaction following exposure to an antigen. Its incidence is progressively increasing in the general population over years, accompanied with an increased number of hospitalizations.
- Trial name
- ANAPHYLASHOCK (NCT04290507)
- Where
- 2 sites in France
- Volunteers
- 339 people
- Sponsor
- Central Hospital, Nancy, France
Food Hypersensitivity, Peanut Hypersensitivity
Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study
Food allergy affects up to 10% of the population. The mainstay of management involves dietary avoidance and provision of rescue medication in the event of an accidental reaction.
- Trial name
- TRACEextension (NCT02665793)
- Testing
- DBPCFC to peanut cookie, Single-dose DBPCFC to peanut flour, Single-dose DBPCFC to peanut butter
- Volunteers
- 17 people
- Sponsor
- Imperial College London
Anaphylaxis
Intravenous Heparin as an Adjunct for the Treatment of Anaphylactic Reactions in an Emergency Department
To determine if intravenous unfractionated heparin (with standard therapy) for treatment of anaphylaxis results in faster time to recovery.
- Trial name
- NCT00657228
- Testing
- Intravenous heparin, Saline
- Where
- 2 sites in United States
- Sponsor
- University of Missouri, Kansas City
Anaphylaxis Caused by Hymenoptera Venom (Disorder)
Hymenoptera Venom Immunotherapy: Evaluation of Its Long-term Efficacy at the University Hospital of Angers (EFLOTITA2)
Allergy to Hymenoptera venom is one of the main causes of anaphylaxis in adults, and is less common in the paediatric population. It can be severe or even fatal.
- Trial name
- EFLOTITA2 (NCT05311644)
- Testing
- Telephone survey
- Where
- France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Angers
Food Allergy
One-year Survey of Anaphylaxis in Outpatient Children Allergic to Peanuts, Walnuts/Hazelnuts, Shellfish
In Italy, few data about anaphylaxis due to peanuts in pediatric age are available, conversely data about walnuts/hazelnuts, shellfish/mollusks anaphylaxis have not yet been collected.
- Trial name
- NCT02640560
- Testing
- Food allergy questionnaire, Control Questionnaire
- Volunteers
- 200 people
- Sponsor
- Stefania La Grutta, MD
Anaphylaxis, Biphasic Anaphylactic Reaction
SHARED Study (Saguenay Hospitals Anaphylaxis Rule for Early Discharge)
Anaphylaxis is a potentially fatal condition with a prevalence between 0.05 and 2% in the general population. This is therefore a frequent reason for emergency visits.
- Conditions
- Anaphylaxis, Biphasic Anaphylactic Reaction, Rebound Anaphylactic Reaction
- Trial name
- SHARED (NCT04755881)
- Testing
- Occurence of biphasic reaction following anaphylaxis
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- Université de Sherbrooke
Anaphylaxis, Allergic Reaction
What is the Allergy Follow-up for Children After Anaphylactic Reaction? AFCAR : Allergy Follow-up for Children After Anaphylactic Reaction
Anaphylaxis is an allergic reaction potentially fatal. The treatment is based on injection of epinephrin as soon as possible. Guidelines by the World Allergic Organisation highlight the importance of medical follow-up.
- Trial name
- SAPRA (NCT03942692)
- Testing
- Phone call questionnaire
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Hospices Civils de Lyon