Clinical trials: Anastomosis, Leaking
Rectal Cancer, Anastomotic Leak
CRP-guided Transanal Drainage Removal After Rectal Surgery
Transanal drainage tube (TDT) has the benefit of reducing intraluminal pressure after rectal surgery and may provide ideal regional environment for anastomotic healing.
- Trial name
- NCT05502354
- Testing
- removal of transanal drainage tube
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Qilu Hospital of Shandong University
ColoRectal Cancer, Colonic Diverticulitis
Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?
A leak from a colorectal anastomosis is a post-operative complication surgeons fear the most, following colonic resection. Over the years, there have been multiple suggestions for intraoperative tests for the integrity of the…
- Conditions
- ColoRectal Cancer, Colonic Diverticulitis, Anastomotic Leak, Anastomotic Complication
- Trial name
- ITCORA (NCT03316677)
- Testing
- Intraoperative testing of colorectal anastomoses, Stapled colorectal anastomoses
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Colorectal Cancer
Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer in the world and the third in France. Its incidence is steadily rising in developing nations.
- Trial name
- FLUOCOL-1 (NCT05168839)
- Testing
- FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG).
- Where
- 32 sites in France
- Volunteers
- 1,010 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rectum Cancer
The Role of Pelvic Peritonization in Laparoscopic or Robotic Low Anterior Resection
A randomized controlled clinical trial to compare the short and long outcomes of low anterior resection for middle-low rectal cancer with or without pelvic peritonization.
- Trial name
- NCT03699761
- Testing
- Closure of the pelvic peritoneum, Nonclosure of the pelvic peritoneum
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southwest Hospital, China
Anastomotic Leak
Transanal Inspection and Management of Low ColoRectal Anastomosis Performed With a New Technique
The technique the investigators propose to perform colorectal and colo-anal anastomosis in patients underwent low and ultra-low anterior resection for rectal cancer could potentially reduce the anastomotic leakage rate by better…
- Trial name
- TICRANT (NCT02879370)
- Testing
- Transanal Inspection and management of low ColoRectal Anastomosis
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- University of Rome Tor Vergata
Endoscopic Vacuum Therapy, Anastomotic Leak
Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract
The goal of this observational study is to learn about the best indications and techniques regarding endoscopic vacuum therapy (EVT) in patients with a transmural defect in the upper gastrointestinal (GI) tract (e.g.
- Conditions
- Endoscopic Vacuum Therapy, Anastomotic Leak, Esophageal Perforation, Esophageal Perforation, Traumatic
- Trial name
- NCT05606822
- Testing
- Observational
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Cancer, Colorectal Anastomosis
Single-Stapled Technique for Colorectal Anastomosis
The goal of this observational multicenter study is to evaluate the safety and feasibility of a single-stapled technique (SST) for colorectal anastomosis and to explore whether this technique is associated with a reduced rate of…
- Conditions
- Colorectal Cancer, Colorectal Anastomosis, Anastomotic Leakage, Diverticular Disease of Left Side of Colon
- Trial name
- SST (NCT07417358)
- Testing
- Single-stapled colorectal anastomosis, Double-stapled colorectal anastomosis
- Where
- 5 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Mediastinitis, Esophageal Neoplasms
Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks
The purpose of this study is to determine the short and long term outcome of endoscopic vacuum assisted closure of intrathoracic postsurgical leaks.
- Conditions
- Mediastinitis, Esophageal Neoplasms, Anastomotic Leakage
- Trial name
- EVACoIL (NCT00876551)
- Testing
- Endoscopic vacuum assisted closure
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Hannover Medical School
Rectal Cancer
Anastomotic Leakage After Anterior Resection of Rectal Cancer
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients.
- Trial name
- NCT03281070
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Adult Patients, Intestinal Continuity (Anastomosis)
Anastomotic Leakage After Colon Cancer Surgery
Anastomotic leak (AL) is one of the most feared complications after colon cancer (CC) surgery. The incidence varies according to the studies, the definition used and the location of the excised segment.
- Conditions
- Adult Patients, Intestinal Continuity (Anastomosis), Colon Cancer
- Trial name
- ANACO II (NCT05643105)
- Testing
- Any kind of colectomy
- Where
- Spain
- Volunteers
- 1,628 people
- Sponsor
- Hospital San Carlos, Madrid
Anastomotic Leakage
The Optimal Width of Gastric Conduit for Minimally Invasive Esophagectomy: Wide or Narrow?
The study hypothesized that a narrow gastric conduit(less than 3cm in width) would minimize anastomotic leakage following minimally invasive esophagectomy.
- Trial name
- NCT01696682
- Testing
- Narrowed Gastric Conduit, Widened Gastric Conduit
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Anastomotic Leak
Use of NERv's Inline Device as an Early Diagnostic Method for Anastomotic Leak.
NERv's early feasibility clinical trial is a first-in-human, multi-center, pre-market, non-randomized clinical trial intended to evaluate the safety and collect preliminary data necessary for the detection of clinical…
- Trial name
- NCT04253028
- Testing
- NERv's Inline Device
- Where
- 2 sites in Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- FluidAI Medical
Postoperative Complications, Psychosomatic Disorder
Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.
- Conditions
- Postoperative Complications, Psychosomatic Disorder, Psychiatric Disorder, Cancer
- Trial name
- NCT05257863
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Anastomotic Leak Rectum
Impact of Obsidian ® ASG on Anastomotic Healing
The use of regenerative medicine in colorectal surgery constitutes an entirely new therapeutic principle. The aim of this new therapeutic approach is to reduce the anastomotic leak rate and minimise morbidity and mortality.
- Trial name
- NCT04386148
- Testing
- Obsidian ASG®
- Where
- Austria
- Volunteers
- 270 people
- Sponsor
- Kepler University Hospital
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Anastomotic Leak Rectum, Rectal Cancer
Treatment of Anastomotic Leakage After Rectal Cancer Resection
The TENTACLE: Rectum study is a multinational retrospective cohort study that includes patients with anastomotic leakage after rectal cancer resection.
- Trial name
- TENTACLE:R (NCT04127734)
- Testing
- The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated
- Volunteers
- 1,246 people
- Sponsor
- Radboud University Medical Center
Anastomotic Leak
Endo-Vac-Therapy for Post-Sleeve Gastrectomy Leaks
Endoscopic negative pressure therapy (ENPT) is a safe technique, showing promising results in the treatment of leakages of the upper and lower gastrointestinal tract.
- Trial name
- NCT05189574
- Testing
- Endoscopic negative pressure therapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ruhr University of Bochum
Rectal Neoplasms
Perfusion Outcomes With Near Infrared-Indocyanine Green Imaging System in Laparoscopic Total Mesorectal Excision for Mid- or Low-rectal CanceR
It is a multicenter, prospective, and randomized controlled clinical study of patients with mid- or low- rectal cancer who received laparoscopic TME surgery aims to explore whether the application of near infrared-indocyanine…
- Trial name
- POSTER (NCT04012645)
- Testing
- application of near infrared-indocyanine green imaging system, Non-application of near infrared-indocyanine green imaging system
- Where
- 2 sites in China
- Volunteers
- 547 people
- Sponsor
- Zhongtao Zhang
Colorectal Cancer
Gut Microbiota, Anastomotic Leak and Colorectal Cancer
This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior.
- Trial name
- NCT04071964
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anastomotic Leak Rectum
Routine Endoscopic Evaluation of Colorectal Anastomoses for Early Detection of Anastomotic Leakage
The objective of this international prospective observational study is to evaluate the implementation of a point-of-care digital rectoscope (LumenEye) into routine care to detect colorectal anastomotic leakage in the early…
- Trial name
- REAL (NCT06493565)
- Testing
- Routine endoscopic anastomosis inspection
- Where
- 5 sites in France, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- Amsterdam UMC, location VUmc