Clinical trials: Anastomosis, Leaking
Anastomotic Leak, Bowel Resection
Intra-Operative Infrared Thermography for Bowel Resection
This prospective randomized control pilot study evaluates the use of intra-operative infrared thermography compared to conventional visual assessment for preventing anastomotic leaks in bowel resection surgeries.
- Conditions
- Anastomotic Leak, Bowel Resection, Intestinal Ischemia
- Trial name
- NCT07906704
- Testing
- Intra-operative Infrared Thermography, Conventional visual assessment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sir Ganga Ram Hospital
Anastomotic Leak Rectum
Evaluation of AL Prediction for Rectal Cancer
Anastomotic leakage is one of the most serious postoperative complications of low rectal cancer, with an incidence of 3%-21%. The occurrence of anastomotic leakage is related to many factors, and the occurrence of anastomotic…
- Trial name
- NCT05610904
- Testing
- Prediction model evaluation
- Where
- China
- Volunteers
- 418 people
- Sponsor
- Changhai Hospital
Rectal Cancer, Anastomotic Leakage
Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection
The goal of this clinical trial is to learn if somatostatin plus a clear liquid diet can help prevent severe leakage after rectal cancer surgery in adults with low or mid rectal cancer who are scheduled to have ultra-low anterior…
- Trial name
- SC-Stoma (NCT07605611)
- Testing
- Somatostatin, Clear Liquid Diet, Prophylactic Diverting Stoma
- Where
- 3 sites in China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Gastric Cancer, Anastomotic Leak
Tisseel® as a Reinforcement of Esophagojejunal Anastomoses
Background: The dehiscence of esophagojejunal anastomoses is one of the most serious complications after total gastrectomy in patients with gastric cancer.
- Trial name
- NCT03733639
- Testing
- Tisseel, No Tisseel
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Germans Trias i Pujol Hospital
Anastomotic Leakage, Rectal Neoplasms
Use of the TDT for Prevention of Anastomotic Leakage After Laparoscopic Anterior Resection for Rectal Cancer
The rate of anastomotic leakage after laparoscopic anterior resection（LAR） for medium \& low rectal cancer is still high. the transanal drainage tube (TDT) was thought to be useful for deduce the rate.
- Trial name
- NCT02686567
- Testing
- with TDT, without TDT
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Third Military Medical University
Colo-rectal Surgery, Anastomotic Leak Large Intestine
Comparison of Rates of Anastomotic Leak in Patients Undergoing Colo-rectal Surgery When Bowel Perfusion and Resection Margin is Deterimined by Intra-operative Infra-red Thermography or by Conventional Method
Pilot RCT with 20 patients in both test and control group. In the control group resection \& anastomosis was done using the conventional method.
- Conditions
- Colo-rectal Surgery, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum
- Trial name
- NCT06180564
- Testing
- Intra-operative Infra-red thermography
- Where
- India
- Volunteers
- 43 people
- Sponsor
- Sir Ganga Ram Hospital
Anastomotic Leak Rectum, Rectal Cancer
Healing of Rectal Anastomosis Sealed With a Concentrate Derived From the Patient's Blood, After Rectal Cancer Surgery
Rectal cancer is one of the most frequent cancer diseases, with more than 1500 new cases per year in Denmark. Fortunately, if the tumor is discovered early, surgeons can remove the part of the intestine that is afflicted, and…
- Conditions
- Anastomotic Leak Rectum, Rectal Cancer, Anastomotic Leakage
- Trial name
- OBANORES (NCT05293054)
- Testing
- Application of autologous fibrin matrix (Obsidian)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Colorectal Cancer, Colon Cancer
MIMICC Study in Patients With Colorectal Cancer
This multicenter prospective interventional study will evaluate stool and saliva microRNA expression and microbiome composition in patients with histologically confirmed colon or rectal cancer during key phases of the diagnostic…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancers
- Trial name
- MIMICC (NCT07494201)
- Testing
- Prospective Biological Sample Collection and Longitudinal Molecular Profiling, Diet and Lifestyle Assessment
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Rectal Cancer Surgery, Perfusion Imaging
Effect of Preserving the Left Colic Artery on Proximal Bowel Perfusion
Patients with rectal or rectosigmoid cancer undergoing radical resection will be randomly assigned to either high-tie (HT) or low-tie (LT) ligation of the Inferior Mesenteric Artery (IMA).
- Conditions
- Rectal Cancer Surgery, Perfusion Imaging, Anastomosis, Leaking
- Trial name
- NCT06982664
- Testing
- High Tie of Inferior Mesenteric Artery, Low Tie of Inferior Mesenteric Artery
- Volunteers
- 143 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Anastomotic Leaks
Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal Surgery
To evaluate the safety and effectiveness of sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE for the treatment of anastomotic leaks in the upper gastrointestinal tract in a prospective multi-center study.
- Trial name
- DRAIN Upper (NCT07711093)
- Testing
- sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Boston Scientific Corporation
Colorectal Disorders, Surgery--Complications
Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections
The complication rate in colorectal surgery is high and shows a large variance depending on the patient and the treating surgeon.
- Conditions
- Colorectal Disorders, Surgery--Complications, Colorectal Cancer, Anastomotic Leak
- Trial name
- NCT04550156
- Testing
- Colorectal Bundle
- Where
- 7 sites in Switzerland
- Volunteers
- 1,141 people
- Sponsor
- University Hospital, Basel, Switzerland
Ulcerative Colitis, Colorectal Cancer
Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at three time points during ileal pouch…
- Conditions
- Ulcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous Polyposis
- Trial name
- NCT04695964
- Testing
- ICG-NIRF Imaging plus ingress and egress analysis
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Rectal Cancer Patients, Anastomotic Leakage
CRP/CT-Guided Selective Ileostomy After LAR
This single-center, parallel-group randomized controlled trial compared routine diverting loop ileostomy with a postoperative CRP/CT-guided selective ileostomy strategy in adults undergoing laparoscopic low anterior resection for…
- Conditions
- Rectal Cancer Patients, Anastomotic Leakage, Low Anterior Resection
- Trial name
- less stoma (NCT07722533)
- Testing
- Serial C-reactive protein-guided computed tomography surveillance and selective omission of defunctioning ileostomy, routine follow up
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Alexandria University
Rectal Cancer Patients, Rectal Cancer Surgery
FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer Surgery
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage…
- Conditions
- Rectal Cancer Patients, Rectal Cancer Surgery, Colorectal Cancer, Anastomotic Leak Rectum
- Trial name
- FLARE (NCT07899125)
- Testing
- Indocyanine Green Fluorescence Angiography, Standard Surgical Perfusion Assessment
- Where
- India
- Volunteers
- 610 people
- Sponsor
- Basavatarakam Indo American Cancer Hospital & Research Institute
Anastomotic Leak, Sigmoid Diseases
Lateral Invagination of the Colorectal Anastomosis by Double Stapling
Anastomotic dehiscence is the most feared complication in colorectal surgery, occurring in 6.3% -13.7% in patients with pelvic anastomoses [1-4].
- Trial name
- NCT04553250
- Testing
- Doubled-stapled colorectal anastomosis
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Colon Neoplasms, Rectal Neoplasms
The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery
In colorectal surgery, anastomotic leak and its septic consequences still remain as the most concerning complications resulting in substantial morbidity and mortality.
- Conditions
- Colon Neoplasms, Rectal Neoplasms, Inflammatory Bowel Disease, Diverticular Disease
- Trial name
- NCT02598414
- Testing
- Near-infrared ICG fluorescence imaging, Traditional bowel anastomosis, FireFly™
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Acibadem University
Anastomosis; Complications, Anastomosis, Surgical
Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer
Colorectal cancer is a very commonly diagnosed malignancy worldwide, and surgical resection remains the mainstay of treatment. Outcomes depend on preoperative staging, surgical quality, complication rates, and multidisciplinary…
- Conditions
- Anastomosis; Complications, Anastomosis, Surgical, Anastomosis, Leaking, Anastomotic Leaks
- Trial name
- NCT07099820
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Saint Camillus International University of Health Sciences
C-Reactive Protein, Anastomotic Leak
C-protein Reactive for the Detection of Anastomotic Leakage After Surgery for Digestive Cancer
The aim of this study is to investigate the diagnostic accuracy of the C Protein Reactive (CRP) for the detection of Anastomotic leakage after surgery for digestive cancer.
- Conditions
- C-Reactive Protein, Anastomotic Leak, Digestive System Neoplasm
- Trial name
- NCT04133324
- Testing
- C-reactive protein
- Where
- Morocco
- Volunteers
- 500 people
- Sponsor
- Moroccan Society of Surgery
Rectal Cancer
Artificial Intelligence Assists Surgeons' Decision Making
This study will evaluate whether artificial intelligence technique reduces the temporary ileostomy rate in patients with rectal cancer who receive anterior resection.
- Trial name
- NCT04999007
- Testing
- Artificial intelligence algorithm
- Where
- China
- Volunteers
- 872 people
- Sponsor
- Jichao Qin