Clinical trials: Anastomosis; Complications, open to volunteers
Colorectal Cancer, Colon Cancer
MIMICC Study in Patients With Colorectal Cancer
This multicenter prospective interventional study will evaluate stool and saliva microRNA expression and microbiome composition in patients with histologically confirmed colon or rectal cancer during key phases of the diagnostic…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancers
- Trial name
- MIMICC (NCT07494201)
- Testing
- Prospective Biological Sample Collection and Longitudinal Molecular Profiling, Diet and Lifestyle Assessment
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Metabolic Surgery, Obesity & Overweight
Hand-Sewn vs. Stapled Anastomosis in SADI-S: Early Postoperative Complications.
This study aims to compare the stapled and handsewn techniques of duodeno-ileal anastomosis in SADI-S regarding short-term outcomes in the form of anastomotic leak rate and anastomotic stricture rate, operative time…
- Trial name
- NCT07348146
- Testing
- Hand-sewn Single Anastomosis Duodeno-Ileal Sleeve (SADI-S), Stapled Single Anastomosis Duodena-ileal Sleeve
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Kasr El Aini Hospital
Leakage, Anastomotic, Colon Cancer
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of…
- Conditions
- Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer
- Trial name
- COLOFLOW (NCT07720505)
- Testing
- Laser Speckle Contrast Imaging
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Anastomotic Leaks, Hartmanns Stump Leakage
Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area
This study is intended to evaluate the safety and effectiveness of Sponge-based Endoscopic Vacuum Therapy (EVT) using Endo-SPONGE for the treatment of Anastomotic Leaks (AL) or Hartmann's stump leakages following colorectal…
- Trial name
- DRAIN Lower (NCT07035431)
- Testing
- Endo-SPONGE
- Where
- 10 sites in United States
- Volunteers
- 66 people
- Sponsor
- Boston Scientific Corporation
Liver Transplantation, Liver Transplant; Complications
EBD RCT Trial in Living Donor Liver Transplantation
This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Bile Stricture, Bile Leakage From Biliary Anastomosis
- Trial name
- NCT04622540
- Testing
- External biliary drainage
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
Liver Transplant; Complications, Bile Duct; Stricture, Postoperative
The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Transplantation
The main objective of the trial is to compare the effect of two end-to-end duct-to-duct anastomosis surgical techniques using the continuous suture method versus interrupted method (control group) on reducing the risk of bile…
- Conditions
- Liver Transplant; Complications, Bile Duct; Stricture, Postoperative, Bile Leak, Quality of Life
- Trial name
- NCT06533592
- Testing
- Continous suture technique, Interrupted suture technique
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- Medical University of Warsaw
Esophageal Cancer, Surgery-Complications
Comparison of Endoscopy and Esophagram for the Routine Evaluation of Anastomosis After McKeown Esophagectomy
This retrospective cohort study reviewed patients who underwent McKeown esophagectomy. All patients routinely underwent either endoscopy or esophagram for the evaluation of anastomosis on postoperative day 7.
- Trial name
- NCT07043491
- Testing
- Endoscopy
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Sun Yat-sen University
Blood Loss, Intensive Care
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission…
- Conditions
- Blood Loss, Intensive Care, Anastomotic Leakage, Lymph Node Disease
- Trial name
- NCT06049758
- Testing
- LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention), Enoxaparin 40 Mg/0.4 mL Injectable Solution, Levofloxacin 500mg
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Colorectal Neoplasia, Anastomotic Leakage
Study on the Correlation Between Serum and Fecal Sialic Acid Levels and Tumor Characteristics as Well as Postoperative Anastomotic Leakage in Patients With Colorectal Tumors
This is a Single-center bidirectional cohort study combined with prospective sample analysis conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital).
- Trial name
- NCT07189663
- Where
- China
- Volunteers
- 1,468 people
- Sponsor
- Xiaolong Li
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Colorectal Surgery, Colorectal Resection
AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer
Surgery can effectively treat colorectal cancer, but it is a complex procedure with risks and complications. Surgeons often rely on cameras to visually guide their instruments during operations, especially in minimally invasive…
- Conditions
- Colorectal Surgery, Colorectal Resection, Anastomosis, Surgical, Fluorescence Guided Surgery
- Trial name
- AUGUR-AI (NCT06708819)
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- Mater Misericordiae University Hospital
Rectal Cancer, Colon Cancer
Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)
Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers.
- Conditions
- Rectal Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT07098182
- Testing
- Clamping and restauration of arterial blood of the inferior mesenteric artery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Cancer, Colorectal Anastomosis
Single-Stapled Technique for Colorectal Anastomosis
The goal of this observational multicenter study is to evaluate the safety and feasibility of a single-stapled technique (SST) for colorectal anastomosis and to explore whether this technique is associated with a reduced rate of…
- Conditions
- Colorectal Cancer, Colorectal Anastomosis, Anastomotic Leakage, Diverticular Disease of Left Side of Colon
- Trial name
- SST (NCT07417358)
- Testing
- Single-stapled colorectal anastomosis, Double-stapled colorectal anastomosis
- Where
- 5 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Rectal Cancer, Surgery Indication
Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)
The objectiive of this prospective, international cohort is to compare two anastomotic techniques (DS vs TTSS) by collecting data during the surgery, and postoperatively (morbidity and functional outcomes).
- Trial name
- OASIS (NCT07146334)
- Where
- 15 sites in Belgium, Canada and 4 more
- Volunteers
- 400 people
- Sponsor
- Bordeaux Colorectal Institute
Colon Cancer
Mechanical Bowel Preparation in Laparoscopic Right Hemicolectomy With Intracorporeal Anastomosis
This study is a randomized controlled trial conducted at University Medical Center Ho Chi Minh City to evaluate the role of mechanical bowel preparation (MBP) in patients undergoing laparoscopic right hemicolectomy with totally…
- Trial name
- UMC-Colprep (NCT07546565)
- Testing
- Mechanical Bowel Preparation, No mechanical bowel preparation
- Where
- Vietnam
- Volunteers
- 74 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Rectal Neoplasms, Rectal Neoplasms Malignant
The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal Cancer
The goal of this clinical trial is to learn whether a modified single-stapled anastomosis (MST) can reduce anastomotic leakage compared with the conventional double-stapled technique (DST) in adult patients undergoing…
- Conditions
- Rectal Neoplasms, Rectal Neoplasms Malignant, Rectal Cancer, Rectal Cancer Surgery
- Trial name
- MST (NCT07376980)
- Testing
- Modified single-stapled anastomosis technique
- Where
- 6 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Korea University Anam Hospital
Colorectal Cancer (CRC), Surgery, Colorectal
Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lymphadenectomy
This study is a randomized, controlled trial comparing the short- and long-term outcomes of left colonic artery or first sigmoid artery preservation for rectal surgery.
- Conditions
- Colorectal Cancer (CRC), Surgery, Colorectal, Oncology
- Trial name
- COLAP-D3 (NCT06938490)
- Testing
- Anterior rectal resection with D3-lymphatic dissection
- Where
- Russia
- Volunteers
- 778 people
- Sponsor
- the BELOOSTROV Clinic of High Technologies
Type2 Diabetes, Complication of Bariatric Procedure
Efficacy and Safety of One-anastomosis Versus Roux-en-Y Gastric Bypass for Type 2 Diabetes Remission
Diabetes mellitus (T2DM) is the most common complication of obesity patients. According to previous literature reports, weight loss and metabolic surgery are powerful means to treat obesity complicated with T2DM.
- Trial name
- ORDER (NCT05015283)
- Testing
- The laparoscopic One-anastomosis gastric bypass will consist of:, The laparoscopic Roux-en-Y gastric bypass will consist of:
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Beijing Friendship Hospital
Lymphedema, Breast Cancer
LymphoVenous Anastomosis to Prevent Breast Cancer Related Lymphedema
Lymphedema is defined as a chronic condition, caused by lymphostasis. A major part in the Western world consists of iatrogenic lymphedema caused by surgery to the lymph nodes of the axilla or groin.
- Trial name
- LVARCT (NCT05601037)
- Testing
- Axilla dissection + Lymphovenous anastomosis
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent