Clinical trials: Anastomotic Leakage
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Human Intestinal Microbiome and Surgical Outcomes in Patients Undergoing Colorectal Cancer Surgery
Intro: Recent studies on colorectal cancer surgery have been focusing on the role of intestinal microbiome on surgical outcomes.
- Trial name
- Microbiota (NCT04005118)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gynecologic Cancer, Anastomotic Leak
ECO-LEAK Technique: Early Detection of Colorectal Anastomotic Leakage by Transvaginal Ultrasound
The main hypothesis is that anastomotic leakage can be predicted peri- and postoperatively.To this end, the aim is to establish the accuracy of transvaginal ultrasound with transrectal enema (Ecoenema-TV) for the diagnosis of…
- Conditions
- Gynecologic Cancer, Anastomotic Leak, Cytoreductive Surgery
- Trial name
- NCT05942209
- Testing
- ECO-LEAK transvaginal ultrasound, ECO-LEAK with CT-Scan or rectoscopy, CT-Scan or rectoscopy
- Where
- Spain
- Volunteers
- 766 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Surgical Anastomosis
ICG Anastomotic Control in Digestive System Surgery
This was a parallel single-center retrospective cohort study conducted at Linglong Yingcheng Hospital, Shandong, China. The purpose of this study was to investigate the effect of indocyanine green (ICG) on patients undergoing…
- Trial name
- NCT06270745
- Testing
- indocyanine green
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong Linglong Yingcheng Hospital
Anastomotic Leak, Anti-Inflammatory Agents, Non-Steroidal
Risk of NSAIDs on Anastomotic Leak for Rectal Surgery
Conflicting reports of the association between early postoperative non-steroidal anti-inflammatory drugs (NSAIDs) administration and anastomotic leak (AL) after rectal surgery have continued.
- Trial name
- NCT06155175
- Testing
- NSAIDs
- Where
- China
- Volunteers
- 1,969 people
- Sponsor
- Third Military Medical University
Rectal Cancer
ReAL Trial (Rectal Anastomotic seaL)
The problem of anastomotic leak is particularly relevant in rectal surgery. Many risk factors have been recognized in the onset of this complication.
- Trial name
- ReAL (NCT03941938)
- Testing
- Cyanoacrylate reinforcement, No reinforcement
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Esophageal Cancer, Anastomotic Leakage
Detection of Anastomotic Leakage After Esophageal Surgery
Anastomotic leakage is a major complication in esophageal surgery. Although contrast swallow is the current standard to exclude anastomotic leakage postoperatively, endoscopy may be superior.
- Trial name
- NCT00642525
- Testing
- Contrast swallow radiography, endoscopy
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Heidelberg University
Rectal Disease, Sigmoid Disease
Evaluation of Intestinal Vascolarization With Indocianine Green Angiography During Rectal Resection or Left Colectomy
A randomized controlled multicenter trial on the usefulness of intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients who undergo laparoscopic rectal resection or left colectomy.
- Trial name
- NCT02662946
- Testing
- ICG- angiography, No angiography
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Scientific Institute San Raffaele
Anastomotic Leakage
SEAL Registry - European Registry for the Effectiveness of LifeSeal® Kit
This study will assess the effectiveness of commercially available LifeSeal® Kit as measured by the incidence of post-operative clinical anastomotic leak rates in subjects undergoing low and ultralow anterior resection with an…
- Trial name
- NCT02881359
- Testing
- LifeSeal® Kit
- Where
- 8 sites in Belgium, Netherlands
- Volunteers
- 200 people
- Sponsor
- LifeBond Ltd.
Colorectal Cancer, Inflammatory Bowel Diseases
Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study
The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Microbiota, Anastomotic Leak
- Trial name
- NCT03496441
- Testing
- Fecal sample collection for analysis
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Esophageal Cancer
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning
This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery.
- Trial name
- NCT06312839
- Testing
- Collecting data from the medical record
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Colorectal Cancer
Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer in the world and the third in France. Its incidence is steadily rising in developing nations.
- Trial name
- FLUOCOL-1 (NCT05168839)
- Testing
- FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG).
- Where
- 32 sites in France
- Volunteers
- 1,010 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Esophageal Squamous Cell Carcinoma
PPIO-005 The Relationship Between Different Nutritional Pathways and Tumor Outcomes After Minimally Invasive Esophagectomy
As there is no consensus to date on the optimal postoperative nutritional support route for patients undergoing minimally invasive esophagectomy, the purpose of this study is to assess whether there is a potential advantage to…
- Trial name
- NCT06192212
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Esophageal Anastomotic Leak, Tissue Pressure of Oxygen
Ischemic Conditioning of the Gastric Conduit in Esophageal Cancer.
This study is a randomized clinical trial to clarify if preoperative embolization of gastric arteries can reduce the incidence of oesophagogastric leakage after an esophagectomy for esophageal cancer comparing an experimental…
- Trial name
- NCT04268654
- Testing
- Preoperative Arterial Embolization
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Esophageal Neoplasms, Esophagostomy Complication
Tissue Oxygen Saturation for Esophagectomy
Tissue oxygen saturation monitoring was a useful indicator of blood flow insufficiency in the gastric tube leading to anastomotic leakage during radical esophagectomy.
- Conditions
- Esophageal Neoplasms, Esophagostomy Complication, Anastomotic Leak, Oxygen Deficiency
- Trial name
- NCT04973046
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Shizuoka Cancer Center
Esophageal Cancer, Esophageal Neoplasms
TreatmENT of AnastomotiC Leakage After Esophagectomy
Rationale: Anastomotic leakage (0% - 30%) is a severe complication after esophagectomy with mortality rates approximately ranging from 2% - 12%. In addition, it is associated with a prolonged ICU treatment and hospital stay.
- Trial name
- TENTACLE (NCT03829098)
- Testing
- Intervantions for anastomotic leakage after esophagectomy
- Where
- Netherlands
- Volunteers
- 1,509 people
- Sponsor
- Radboud University Medical Center
Anastomotic Leak, Colorectal Neoplasms
Enhanced Recovery and Patient Blood Management in Colorectal Surgery
To prospectively study the effect of adherence to ERAS and PBM programs on early outcomes after colorectal surgery
- Conditions
- Anastomotic Leak, Colorectal Neoplasms, Blood Transfusion Complication, Colorectal Disorders
- Trial name
- iCral4 (NCT05227014)
- Testing
- Colorectal resection
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Ospedale Sandro Pertini, Roma
Advanced Gastric Carcinoma
Prospective Study on Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers
The purpose of this study is to explore the clinical application value of Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers.
- Trial name
- NCT05545293
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Blood Loss, Intensive Care
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission…
- Conditions
- Blood Loss, Intensive Care, Anastomotic Leakage, Lymph Node Disease
- Trial name
- NCT06049758
- Testing
- LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention), Enoxaparin 40 Mg/0.4 mL Injectable Solution, Levofloxacin 500mg
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Colorectal Cancer Recurrent
Microbiome and Colorectal Cancer Recurrence
Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown.
- Trial name
- NCT07057076
- Volunteers
- 51 people
- Sponsor
- Hospital del Mar