Clinical trials: Anastomotic Leakage
Rectal Cancer, Anastomotic Leak
Does the Management of Anastomotic Leakage After Low Rectal Resection Affect Survival
The aim of this retrospective cohort-study is to assess the effects of AL and its severity divided according the ISREC-classification on the long-term oncological outcome.
- Trial name
- ISRECLeak (NCT06059924)
- Testing
- Anastomotic leakage
- Where
- Switzerland
- Volunteers
- 941 people
- Sponsor
- Cantonal Hospital of St. Gallen
Esophageal Cancer, Esophagus Cancer
Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer
A prospective, multi-centre, exploratory and observational one-arm study to evaluate preventive Endoluminal Vacuum Therapy(pEVT) to prevent anastomotic leakage after esophagectomy due to esophageal cancer.
- Conditions
- Esophageal Cancer, Esophagus Cancer, Anastomotic Leak
- Trial name
- ESPY (NCT06097078)
- Testing
- Eso-SPONGE®
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Aesculap AG
Colorectal Cancer (CRC), Rectal Cancer Surgery
Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery
Anastomotic leakage remains a major complication after colorectal cancer surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time intraoperative assessment of bowel perfusion; however, its clinical impact…
- Conditions
- Colorectal Cancer (CRC), Rectal Cancer Surgery, Sigmoid Colon Cancer
- Trial name
- NCT07423130
- Where
- Poland
- Volunteers
- 115 people
- Sponsor
- Jagiellonian University
Rectal Cancer, Retention, Urinary
Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
DESIGN: Randomized, open-label and parallel clinical trial, assigned to early, mid, or late withdrawal of urinary catheter with a 1: 1: 1 allocation ratio.
- Conditions
- Rectal Cancer, Retention, Urinary, Urinary Tract Infections, Surgical Site Infection
- Trial name
- RAOREC (NCT04751149)
- Testing
- Removal of Urinary Catheter
- Where
- Spain
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Anastomotic Leakage
Anastomotic Leakage Following Laparoscopic Resection for Rectal Cancer
Anastomotic leak (AL) is a breakdown of a suture line in a surgical anastomosis with a subsequent leakage of the luminal content.
- Trial name
- NCT02718729
- Testing
- Laparoscopic resection for rectal cancer
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 59 people
- Sponsor
- Mansoura University
Postoperative Complications
Probiotics in the Prevention of Complications After Colorectal Surgery
Based on the need of large-scale, trials to explore the use of probiotics to reduce post-operative complication rate, a randomized controlled trial is designed to investigate the impact of a probiotics treatment protocol on…
- Trial name
- NCT02313519
- Testing
- Probiotics
- Volunteers
- 164 people
- Sponsor
- Evangelos J. Giamarellos-Bourboulis, M.D.
Intestinal Anastomosis
Emergency Intestinal Anastmosis
The goal of this clinical trial is to compare the outcomes of emergency intestinal anastomosis after stapled and handsewn anastmosis.
- Trial name
- NCT07321743
- Testing
- emergency intestinal anastmosis surgery
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Zagazig University
Complication, Anastomotic Leak
Prediction of Intra-abdominal Infectious Complication by Drainage Fluid Analysis
In our previous study, a nomogram model was established to predict intra-abdominal infectious complications after gastrointestinal surgery.
- Conditions
- Complication, Anastomotic Leak, Intraabdominal Infections, Inflammatory Response
- Trial name
- APPEAL-GC (NCT03862378)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Anastomotic Leak, Rectal Cancer
Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Rationale: The surgical complication of intestinal anastomotic leak remains a clear and present danger to patients despite advances in surgical technique and ever more powerful antibiotics.
- Trial name
- SES-DTA (NCT02682485)
- Testing
- Cipro, metronidazole, neomycin combo, Serial Endoscopic Surveillance, Saline
- Sponsor
- University of Chicago
Rectal Cancer
ReAL Trial (Rectal Anastomotic seaL)
The problem of anastomotic leak is particularly relevant in rectal surgery. Many risk factors have been recognized in the onset of this complication.
- Trial name
- ReAL (NCT03941938)
- Testing
- Cyanoacrylate reinforcement, No reinforcement
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Pancreatic Anastomotic Leak, Pancreatic Neoplasms
Pancreatic Anastomosis After Duodenopancreatectomy
A national, multicenter, randomized, prospective, parallel group clinical study to evaluate two therapeutic strategies (invaginating pancreatogastric anastomosis versus Blumgart anastomosis).
- Trial name
- PANGASBLUM (NCT04462354)
- Testing
- Blumgart Anastomosis, Pancreatogastric anastomosis.
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Colorectal Cancer, Colorectal Surgery
Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Surgery, Complications, Anastomotic Leakage
- Trial name
- NCT07208786
- Testing
- PEVT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Nanchong Central Hospital
Colorectal Cancer, Surgery
Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe)
Aim of this study is to implement the intestinal microbiota by perioperative administration of probiotics, oral antibiotics and low volume mechanical preparation in order to reduce the incidence of colorectal anastomotic leaks…
- Conditions
- Colorectal Cancer, Surgery, LAP, Anastomotic Leak
- Trial name
- MIRACLe (NCT05164887)
- Testing
- Laparoscopic colorectal resection
- Where
- Italy
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- S.Eugenio Hospital
Anastomotic Leak
Non-invasive Detection of Anastomotic Leakage
Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with malignant tumors of the esophagus or pancreatic head.
- Trial name
- NCT03203434
- Testing
- Urinary volatile organic compound analysis
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Esophageal Neoplasms, Esophagectomy
Effect of Neck Flexion on Esophagogastric Anastomotic Leakage After MIE
Esophageal cancer (EC) is the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. Minimally invasive esophagectomy (MIE) is regarded as a safe and effective management for resectable EC.
- Conditions
- Esophageal Neoplasms, Esophagectomy, Anastomotic Leak
- Trial name
- NCT02418052
- Testing
- neck flexion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight
The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication
This study evaluates a new surgical device - the Metallic Anastomotic Clip (MAC) - for performing a laparoscopic bypass gastroenteroanastomosis with entero-enteric anastomosis (transit bipartition / "dual-path" procedure) in…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight, Marginal Ulcer (Peptic) or Erosion, Leakage, Anastomotic
- Trial name
- MACBIPARTFCG (NCT07495020)
- Testing
- Laparoscopic transit bipartition with Metallic Anastomotic Clip and Circular Fundocorporeal Gastroplication, Laparoscopic transit bipartition (gastroenteroanastomosis and entero-enteric anastomosis) use the Metallic Anastomotic Clip and with sleeve gastrectomy, laparoscopic duodenal transit bipartition using the Metallic Anastomotic Clip with circular fundocorporeal gastroplication without gastrectomy
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Colorectal Cancer, Colorectal Neoplasms
Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage
This is a randomized, controlled, parallel, multicenter trial to determine the difference in post-operative anastomotic leakages in colorectal surgery, where anastomosis perfusion is evaluated using indocyanine green fluorescence…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Gastrointestinal Cancer, Gastrointestinal Neoplasms
- Trial name
- ICG-COLORAL (NCT03602677)
- Testing
- ICG fluorescence imaging
- Where
- 2 sites in Finland
- Volunteers
- 1,062 people
- Sponsor
- Oulu University Hospital
Anastomotic Leak
Risk Factors Associated With Anastomotic Leak and Perioperative Mortality in Elderly
This is a retrospective cohort study of all consecutive patients who underwent colon or rectal resection, between the years 2012-2017 at Rabin Medical Center, a tertiary referral center in Israel.
- Trial name
- NCT04518384
- Testing
- colon or rectum resection
- Where
- Israel
- Volunteers
- 536 people
- Sponsor
- Rabin Medical Center
Leaks, Anastomotic
Stent Therapy Versus Endoscopic Vacuum Therapy for Anastomotic Leaks After Esophagectomy
Exploratory study of the efficiency of endoscopic stenting versus endoscopic vacuum therapy in patients with intrathoracic esophago-gastric anastomotic leakage after oncological resection of the esophagus.
- Trial name
- EsoLeak (NCT03962244)
- Testing
- EsoSponge, Self-Expanding Metal Stent
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital of Cologne
Stoma Ileostomy, Stoma Colostomy
Conventional Hand Sewn End-To-End Anastomosis Versus Side-To-Side Anastomosis for Stoma Reversal: A Prospective Study
The goal of this clinical trial is to compare approaches to enterostomy reversal by hand-sewn end-to-end anastomosis versus side-to-side anastomosis (sub-divided into hand-sewn side-to-side anastomosis and stapled side-to-side…
- Conditions
- Stoma Ileostomy, Stoma Colostomy, Anastomosis, Ileus
- Trial name
- NCT05753709
- Testing
- Hand sewn end-to-end anastomosis, Hand sewn side-to-side anastomosis, Stapled side-to-side anastomosis
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Sawai Mansingh Medical College