Clinical trials: Androgens
Healthy
Effect of Dihydrotestosterone (DHT) on Prostate Tissue [Short Title: DHT-3]
The purpose of this research study is to understand the effects of a male hormone normally made in the body called Dihydrotestosterone (DHT) on the prostate gland that is located under the bladder.
- Trial name
- DHT-3 (NCT00490022)
- Testing
- Dihydrotestosterone (DHT) gel (0.7%)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dihydrotestosterone, Testosterone
Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments
This study is a randomized, double-blind, placebo-controlled trial examining the effects of creatine monohydrate supplementation on androgens and hair loss in free-living adult males.
- Conditions
- Dihydrotestosterone, Testosterone, Hair Loss
- Trial name
- NCT04298840
- Testing
- Creatine Monohydrate Supplementation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University
Psoriasis Vulgaris
Hormonal Associations in Male Patients With Psoriasis Vulgaris
A cross sectional clinical study will be conducted on male patients with moderate and sever psoriasis vulgaris to: Identify the pattern of serum testosterone level and tissue androgen receptors.
- Trial name
- NCT05716152
- Testing
- Morning blood sample and skin punch biopsy of 4 mm diameter.
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Sohag University
Transgender, Healthy
Hormone Secretion in Transgender Males
Aim 1 utilizes prospective clinical studies in TGN to test the hypothesis that prolonged exogenous androgens alter menstrual cyclicity by inhibiting gonadotropin secretion, steroid hormone release, and ovulation.
- Trial name
- NCT04321551
- Testing
- Testosterone Cyp 200Mg/Ml Inj (in Oil), Letrozole
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Transgenderism, Reproductive Issues
Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.
- Trial name
- NCT07092527
- Testing
- Testosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy Males, Male Contraceptive
Oral T7 Oral Testosterone in Man
The purpose of this study is to test how the body absorbs and processes new forms of oral testosterone. Information gained during the study may help develop better forms of testosterone therapy in the future.
- Trial name
- Oral T7 (NCT00842751)
- Testing
- First Intervention (7 days), First Washout (7 days), Second Intervention (7 days)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Washington
Fertility Disorders
TRAP Study: Testosterone for Androgen Receptor Polymorphism
To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen…
- Trial name
- TRAP (NCT06195163)
- Testing
- Transdermal Gel in Sachet Dosage Form, No pretreatment
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Infertility, Ovarian Hyperstimulation Syndrome
Monitoring the Early Follicular Phase With Androstenedione in Low-dose Step-up Ovulation Induction in High Responders
This study aims to predefine the threshold FSH doses during the early follicular phases in low- dose step-up ovulation induction cycles used to treat anticipated high responders by monitoring total testosterone and…
- Trial name
- NCT02329483
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
PCOS Disease
Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.
In this study, the investigators wanted to investigate the energy homeostasis and the steroid metabolism of 20 healthy, young and normal weight women aged between 16-35 years before and after a 48 hours fasting period.
- Trial name
- SEA (NCT03573063)
- Testing
- Androgen metabolism after starvation
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Subjects, Androgen Deficiency
Study to Test Safety, Tolerability and Blood Levels of GSK971086 After 1 Dose & 7 Days of Dosing in Healthy Adult Males
This research study is the first administration of GSK971086 in humans. The purpose of this study is to assess the safety and tolerability of GSK971086, as well as, how much GSK971086 is in your blood after different doses
- Trial name
- NCT00540553
- Testing
- GSK971086
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Prostate Cancer
GM-CSF for Maintenance of Prostate Cancer for Patients Responding to Taxotere
This trial is designed to investigate the efficacy and safety of GM-CSF used as a maintenance program in patients with androgen-independent prostate cancer (AIPC) who have achieved a maximal response on a taxotere or other…
- Trial name
- NCT00274287
- Testing
- GM CSF
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oncology Specialists, S.C.
Hypogonadism, Benign Prostatic Hyperplasia
TRADE-Testosterone Replacement and Dutasteride Effectiveness
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the…
- Trial name
- TRADE (NCT00194675)
- Testing
- Dutasteride, Testosterone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Prostate Cancer
Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients.
- Trial name
- NCT03275181
- Testing
- Transthoracic Echocardiography, Arterial blood pressure, Submaximal Exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Polycystic Ovary Syndrome
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome
The primary objective is to determine if meals of different fat and fiber content affect postprandial plasma testosterone concentration in women with polycystic ovary syndrome.
- Trial name
- NCT00455338
- Testing
- Meal Composition
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cachexia
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of GSK2881078 in Single and Repeat Doses
This study is the first administration of GSK2881078 to humans. The intention of this study is to provide sufficient confidence in the safety of the molecule to inform progression to further repeat dose and proof of concept…
- Trial name
- NCT02045940
- Testing
- GSK2881078
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Polycystic Ovary Syndrome, Healthy Pregnant Women
Androgen Metabolism and Reproductive Outcome
The aim of this study is to determine maternal androgen metabolism during pregnancy and the impact of androgen disorders on mothers and infants.
- Trial name
- NCT02106676
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Contraception, Hypogonadism
ORAL T-6: Oral Androgens in Man-6
We propose a study to determine the single-dose pharmacokinetics of these two novel formulations of testosterone in normal men with experimentally induced hypogonadism.
- Trial name
- ORAL-T-6 (NCT00663793)
- Testing
- Acyline, Testosterone, Finasteride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Polycystic Ovary Syndrome
Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine the relationship between lipid-induced inflammation and ovarian androgen secretion in women with polycystic ovary syndrome (PCOS); and to examine the effect of salsalate and polygonum…
- Trial name
- ELI-ROAS (NCT01489319)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Indiana University
Evaluations, Diagnostic Self, Treatment Adherence
Impact of Vitamin D Supplementation on Cardiometabolic Status and Androgen Profile in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of reproductive, endocrine and metabolic functions. Vitamin D has an influence on metabolic and reproductive functions.
- Trial name
- NCT04117750
- Testing
- cholecalciferol (vit D3)
- Where
- Egypt
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Spinal and Bulbar Muscular Atrophy, Kennedys Disease
Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
Background: SBMA is an inherited chronic disease. It affects males in mid to late adulthood. It causes slowly progressive weakness of muscles and hand tremors. Researchers want to learn more about the effects of SBMA.
- Conditions
- Spinal and Bulbar Muscular Atrophy, Kennedys Disease, Motor Neuron Disease
- Trial name
- NCT04944940
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)